Nicotinamide mononucleotide microcapsule and preparation method thereof

A single nucleotide and nicotinamide technology, applied in microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve problems such as high water solubility, difficulty in achieving long-acting, stable effects, and single ingredients

Inactive Publication Date: 2020-12-18
深圳深刻实验室有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Nicotinamide mononucleotide has high water solubility, less absorption by renal tubules, and is easily excreted from the body through urine; After ingestion, the peak value of mononucleotide increases suddenly, far exceeding the amount required by the human body, and then drops sharply. It is difficult to achieve long-term and stable effects. It needs to be used multiple times a day to achieve anti-aging effects. Use poor compliance
[0004] Most of the existing antioxidant free radicals on the market are independent antioxidant ingredients. Although these ingredients play a certain role in the antioxidant free radicals, they are beneficial to maintaining the health of the body; The ingredients contained in antioxidants are relatively simple, and they cannot make up for the loss in the metabolic process at the same time, so they cannot better eliminate the health hazards generated in the energy metabolism of the human body

Method used

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  • Nicotinamide mononucleotide microcapsule and preparation method thereof
  • Nicotinamide mononucleotide microcapsule and preparation method thereof
  • Nicotinamide mononucleotide microcapsule and preparation method thereof

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Embodiment Construction

[0011] In a first aspect, the present invention provides a microcapsule.

[0012] A microcapsule comprising: a capsule core and a capsule material, the capsule core comprising nicotinamide mononucleotide and / or its pharmaceutically acceptable salt, resveratrol, amino acid and / or its derivatives , antioxidants and emulsifiers.

[0013] The amino acid may include at least one selected from threonine, phenylalanine, isoleucine, valine, lysine, tryptophan, leucine or methionine.

[0014] The amino acid derivatives include at least one selected from S-adenosylmethionine and β-hydroxy-β-methylbutyrate. In some preferred embodiments, the amino acid derivative is S-adenosylmethionine.

[0015] The capsule material may include a blocking agent.

[0016] The retarder can be selected from water-insoluble wall materials.

[0017] The water-insoluble wall material may include at least one selected from polyamide, methylcellulose, gelatin, Arabic gel and ethylcellulose. In some embodim...

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Abstract

The invention relates to a nicotinamide mononucleotide microcapsule and a preparation method thereof, and belongs to the field of medicine / health care product preparations. The microcapsule comprisesa capsule core material and a capsule wall material, wherein the capsule core material comprises nicotinamide mononucleotide and / or pharmaceutically acceptable salt thereof, resveratrol, amino acid and / or derivative thereof, an antioxidant, an emulsifier and the like. The microcapsule safely, stably and durably exerts anti-aging and anti-oxidation effects. The preparation method is stable and lowin cost, and the prepared microcapsule is good in slow release property, uniform in particle and uniform in content.

Description

technical field [0001] The invention relates to the field of medicine / health product preparations, in particular to a nicotinamide mononucleotide microcapsule and a preparation method thereof. Background technique [0002] Nicotinamide mononucleotide (NMN, nicotinamide mononucleotide), which belongs to the precursor substance of nicotinamide adenine dinucleotide, provides this kind of NAD+ precursor substance with preventive and therapeutic effects, and relieves age-related pathological and disease states. As well as metabolic benefits, enhancing the activity of the SIRTs family, reducing the expression of inflammation-related genes, reducing oxidative stress, and improving cardiac rhythm, reducing age-related inflammation in adipose tissue, and improving systemic insulin sensitivity. Existing research results have shown that NMN can promote mitochondrial function, including promoting the ability of mitochondrial oxidative phosphorylation and increasing mitochondrial lipid o...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K47/34A61K47/38A61K31/706A61K31/7076A61P39/06A61P3/02A61K31/05A61K31/198
CPCA61K9/5031A61K9/5042A61K31/05A61K31/198A61K31/706A61K31/7076A61P3/02A61P39/06A61K2300/00
Inventor 王江懿
Owner 深圳深刻实验室有限公司
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