Preparation method of traditional Chinese medicine composition for preventing or/and treating dyslipidemia

A technology for dyslipidemia and composition, which is applied in the field of preparation of traditional Chinese medicine compositions, can solve the problems such as the description that the pathological state of "phlegm and blood stasis" in patients is not significantly improved, the blood-activating power is small, and the prevention and control has no significant effect.

Active Publication Date: 2020-12-11
GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

However, statins and fibrates are the main western medicines used clinically in Western medicine. Although these western medicines have a significant effect on improving dyslipidemia, there is no relevant description of the significant improvement in the pathological state of patients with "phlegm and blood stasis".
[0004] The existing medicines for the treatment of dyslipidemia with phlegm and blood stasis mainly include Zhibitai Capsules, Naoxintong Capsules, Yindanxinnaotong Soft Capsules and other common Chinese patent medicines. , "Red yeast rice" exerts the main effect of "activating blood circulation and removing blood stasis", but the two drugs have small blood-activating power and do not have the effect of dredging collaterals. There is no description of significant effect in the prevention and control of other complications in the next step; Naoxintong capsule focuses on "Qi deficiency and blood stasis" type cardiovascular and cerebrovascular diseases; Yindan Xinnaotong Soft Capsules focuses on "qi stagnation and blood stasis" type cardiovascular and cerebrovascular diseases. Some studies have found that it has the effect of improving hyperlipidemia, but it is not its main curative effect , and there is no significant effect description on the pathological elements of "phlegm turbidity"

Method used

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  • Preparation method of traditional Chinese medicine composition for preventing or/and treating dyslipidemia
  • Preparation method of traditional Chinese medicine composition for preventing or/and treating dyslipidemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Example 1 Preparation of Qilong Xuemaijian Granules

[0067] 1) Prepare API according to the following weight ratio (unit: ×10g)

[0068] Coptis 6, Frankincense 9, Myrrh 9, Xuejie 6, Pinellia 9, Quan Gulou 15, Gynostemma 15, Poria 30, Pangshanlong 15, among them, Frankincense is fried frankincense with vinegar; Myrrh is fried myrrh with vinegar;

[0069] 2) After cleaning the raw medicinal materials Coptis chinensis, frankincense, myrrh, Pinellia sinensis, melon, Gynostemma pentaphyllum, Poria cocos, and pansandra, put them in a multi-functional extraction kettle of traditional Chinese medicine and mix them evenly, add tap water to soak for 30 minutes (usually 20-90 minutes), Wherein, the ratio of the weight of the tap water added to the weight (dry weight) of the medicinal material mixture is 9:1 (usually 1-15:1);

[0070] 3) Turn on the power supply of the multi-function extraction kettle for heating, heat to 100° C., keep at this temperature for constant temperature...

Embodiment 2

[0079] Embodiment 2 The preparation of Qilong Xuemai Jian Pill

[0080] 1) Prepare API according to the following weight ratio (unit: ×10g)

[0081] Coptis 3, Frankincense 6, Myrrh 9, Dried Blood 9, Pinellia 6, Quan Gulou 15, Gynostemma 15, Poria 30, Panshanlong 30

[0082] 2) After rinsing the medicinal materials Coptis chinensis, frankincense, myrrh, Pinellia sinensis, melon, Gynostemma pentaphyllum, Poria, and pansandra, place them in a multi-functional extraction kettle of traditional Chinese medicine and mix them evenly, add tap water and soak for 60 minutes, wherein the weight of the added tap water is equal to The weight (dry weight) ratio of the medicinal material mixture is 6:1;

[0083] 3) Turn on the power supply of the multifunctional extraction kettle for heating, heat to 80°C, keep at this temperature for constant temperature extraction for 5 hours, and then filter to obtain the first extraction solution for use;

[0084] 4) Then add tap water to the filter res...

Embodiment 3

[0089] Example 3 Preparation of Qilong Xuemaijian Tablets

[0090] 1) Prepare API according to the following weight ratio (unit: ×10g)

[0091] Coptis 9, Frankincense 9, Myrrh 6, Dried Blood 3, Pinellia 9, Quan Gulou 9, Gynostemma 30, Poria 15, Panshanlong 10

[0092] 2) After cleaning the raw medicinal materials Coptis chinensis, frankincense, myrrh, melon, Gynostemma pentaphyllum, Poria, and pansandra, place them in a multi-functional extraction kettle of traditional Chinese medicine, add tap water to soak for 20min (usually 20-90min), wherein, the added tap water The ratio of weight to weight (dry weight) of the herbal mixture is 12:1 (usually 1-15:1);

[0093] 3) Turn on the power supply of the multi-function extraction kettle for heating, heat to 80°C, keep at this temperature for constant temperature extraction for 5h, and then filter to obtain the first extraction solution for use;

[0094] 4) then add tap water to the filter residue 3 times, heat and extract 3 times,...

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Abstract

The invention discloses a preparation method of a traditional Chinese medicine composition for preventing or / and treating dyslipidemia. The preparation method comprises the following steps of mixing rhizoma coptidis with frankincense, myrrh, pinellia tubers,snakegourd fruits, fiveleaf gynostemma herbs, poria cocos, dioscorea nipponica makino and water, performing heating, performing extracting, and concentrating an extracting solution; crushing dragon's blood into dragon's blood powder; and mixing the concentrated extracting solution with the dragon's blood powder. The method for preparing thetraditional Chinese medicine composition for treating dyslipidemia is simple in process and mild in preparation process condition, the medicine effect of raw material medicines is reserved to the maximum extent, and the traditional Chinese medicine composition prepared by the method is suitable for the dyslipidemia condition, especially the hyperlipidemia symptom. The traditional Chinese medicinecomposition can be made into any common oral preparations and health-care products, has the effects of resolving phlegm, promoting blood circulation, reducing turbidity and dredging collaterals, improves dyslipidemia, achieves the purpose of remarkably reducing blood fat, and is particularly suitable for application of phlegm and blood stasis intermingled dyslipidemia. The preparation method disclosed by the invention is easy to operate and environment-friendly, the production cost is reduced, and the economic benefit is improved.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine composition, in particular to a preparation method of a traditional Chinese medicinal composition for treating dyslipidemia, and belongs to the field of traditional Chinese medicine. Background technique [0002] The disordered state of blood lipids can create an environment for the occurrence and development of atherosclerosis. Hyperlipidemia in adulthood increases the subsequent risk of coronary heart disease in a dose-dependent manner, and long-term exposure to non-HDL cholesterol in adults may increase the risk of future coronary heart disease. Several clinical trials of lipid-lowering drugs and related epidemiological studies have also confirmed the relationship between serum cholesterol levels and the risk of coronary heart disease. At the same time, hyperlipidemia is also an important condition for the development of diabetes, periodontitis and other diseases. Stud...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61K36/896A61P3/06
CPCA61K36/718A61K36/324A61K36/328A61K36/8888A61K36/428A61K36/424A61K36/076A61K36/8945A61K36/889A61K36/896A61P3/06A61K2300/00
Inventor 胡元会崔翰明师帅张秋燕杜柏褚瑜光王欢邱志凌
Owner GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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