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Force-induced response drug controlled-release multifunctional wound dressing and preparation method and application thereof

A wound dressing, multi-functional technology, applied in medical science, bandages, etc., can solve the problems of difficult to control internal drug release, stimulate and regulate active drug release, poor ductility, etc., achieve good sterilization and anti-protein adsorption, clever concept , the effect of simple preparation method steps

Inactive Publication Date: 2020-12-01
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional hydrogel dressings usually have weak mechanical properties, poor ductility, are limited to static wounds, and are difficult to regulate the release of internal drugs.
In order to adapt to superficial wounds in frequent body activities, Chinese patent CN107041963A discloses a hydrogel-elastomer composite wound dressing containing a highly elastic matrix layer and a healing-promoting skin contact layer, which has similar elasticity and elasticity to skin tissue. Tough and waterproof, keep cells hydrated and protected from bacteria, but they cannot regulate the release of active drugs through external stimuli

Method used

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  • Force-induced response drug controlled-release multifunctional wound dressing and preparation method and application thereof
  • Force-induced response drug controlled-release multifunctional wound dressing and preparation method and application thereof
  • Force-induced response drug controlled-release multifunctional wound dressing and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Step 1: Add 0.006 mol / L acrylylated Pluronic F127 (F127DA) and 0.0015 mol / L rifampicin to 5 mL of dichloromethane (DCM), fully dissolve, and dry in a vacuum oven after the DCM has evaporated. Add 2.5 mL of deionized water, shake in a constant temperature shaking box until the solution is clear and transparent, and a stable micellar solution is obtained.

[0062] Step 2: Add 4mol / L [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA) to the solution in step 1, stir until fully dissolved .

[0063] Step 3: Add 0.003mol / L N,N'-methylenebisacrylamide, stir to dissolve, add 0.005mol / L ammonium persulfate, add 2 drops of tetramethylethylenediamine after fully dissolved, mix well and trigger free radicals Polymerize and stand overnight at room temperature to obtain a hydrogel.

[0064] According to the mechanical property test, the elongation at break of the prepared hydrogel can reach 1,420%, and the break stress is 112kPa. The stress of the hydrogel...

Embodiment 2

[0068] Compression release experiment: take the hydrogel prepared in Example 1 to make a disk-shaped sample with a diameter of 15 mm and a thickness of 2 mm. Put into a container containing 6mL deionized water (6.3×3.7×1.2cm 3 ), so that the hydrogel is completely submerged. The hydrogel was cyclically compressed at a constant speed of 6 s / cycle at 40%, 50%, and 60% compressive strain. In the control group, the hydrogel was placed in the same volume of deionized water without compression. At intervals of every 40 compression cycles (or 240s), take 4mL of the solution to be tested for drug concentration, and at the same time replenish the container with the same volume of deionized water. The drug concentration in the solution was measured by a UV-vis spectrophotometer, and the cumulative release rate of the drug was calculated. The antibacterial properties of the drug-releasing solutions were determined by the zone of inhibition method.

[0069] The release rate of the dru...

Embodiment 3

[0071] Tensile release test: the hydrogel prepared in Example 1 was taken to make an effective release volume of a cuboid sample with a length of 20 mm, a width of 25 mm, and a thickness of 2 mm, and was immersed in a container with 10 mL of deionized water (10 × 3.7 × 1cm 3 ). The hydrogel was cyclically stretched at a constant speed of 6 s / cycle at 60%, 80% tensile strain. In the control group, the hydrogel was placed in the same volume of deionized water without stretching. At intervals of every 50 compression cycles (or 300s), take 4mL of the solution to be tested for drug concentration, and at the same time add the same volume of deionized water to the container. The drug concentration in the solution was measured by a UV-vis spectrophotometer, and the cumulative release rate of the drug was calculated. The antibacterial properties of the drug-releasing solutions were determined by the zone of inhibition method.

[0072] The release rate of the drug in the hydrogel un...

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Abstract

The invention discloses a force-induced response drug controlled-release multifunctional wound dressing. The multifunctional wound dressing comprises hydrogel and a drug loaded on the hydrogel. The invention further discloses a preparation method and application of the multifunctional wound dressing. By adopting the multifunctional wound hydrogel dressing disclosed by the invention, when the hydrogel is deformed under the action of mechanical forces, such as tensile force and pressure, the release of active drugs in the hydrogel can be regulated and controlled, and the drugs are promoted to permeate into skin tissues; therefore, the multifunctional wound dressing can be applied to infection resistance, pain alleviation, healing promotion and the like of various stressed wounds.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a drug-controlled release multifunctional wound dressing and its preparation method and application. Background technique [0002] Joint wounds, diabetic foot ulcers, etc. are currently several types of wounds that are difficult to heal clinically. For example, the finger joints, elbow joints, knee joints, shoulder joints, wrist joints, ankle joints and other parts are subjected to stretching due to frequent bending activities; the soles of the feet are subject to pressure due to walking movements, etc. Once the above-mentioned parts are injured, the skin will deform under the action of mechanical force, causing the wound to be frequently pulled, squeezed, etc., interfering with the healing process, increasing the chance of bacterial infection, delaying or even making it difficult for the wound to heal. At the same time, the effect of mechanical force on the wound...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/008A61L26/0066A61L26/0061A61L26/0019A61L2300/602A61L2300/404A61L2300/402A61L2300/412A61L2300/406A61L2300/41A61L2300/216C08L71/02
Inventor 方堃王荣徐婷王镇武陈静付俊
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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