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Colchicine combination formulation for treating liver diseases or enhancing curative effect

A technology for colchicine and liver disease, applied in the field of compound preparations, can solve the problems of unclear liver fibrosis, no therapeutic drugs have been developed, etc., and achieve the effect of improving the curative effect

Pending Publication Date: 2020-11-27
艾斯生物医药株式会社
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  • Abstract
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AI Technical Summary

Problems solved by technology

But so far, the mechanism of liver fibrosis itself has not been clarified, so no suitable therapeutic drugs have been developed

Method used

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  • Colchicine combination formulation for treating liver diseases or enhancing curative effect
  • Colchicine combination formulation for treating liver diseases or enhancing curative effect
  • Colchicine combination formulation for treating liver diseases or enhancing curative effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0059] 1. Preparation of Experimental Animals and Experimental Methods

[0060] 6-week-old C57BL / 6J strain male mice were fed with normal (normal diet, ND) or high fat (High Fatdiet, HFD) diet for 6 weeks, and then administered with colchicine (10g / kg) alone or with colchicine Alkali (10μg / kg) / metformin (50mg / kg) was administered in combination, and the drug was taken together with a high-fat diet for 6 weeks, with oral gavage 3 times a week.

[0061] figure 1 is a schematic diagram of the procedure for preparing the animals and for the examination with colchicine alone and with the colchicine / metformin combination.

[0062] Such as figure 2 As shown, when mice gaining weight were administered with colchicine alone and colchicine / metformin combination by high fat diet by the method described, the body weight of all mice did not change much at this time.

[0063] 2-1. Histopathological examination of liver tissue in obese mice administered with colchicine alone and in comb...

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Abstract

The present invention relates to a combination formulation for treating liver disease or enhancing a curative effect, and in particular to a combination formulation prepared from colchicine and metformin as main effective ingredients. The composition of the present invention can reduce the amount of fat accumulated in liver tissue through the synergistic effect of colchicine and metformin, reduceglucose tolerance and insulin resistance, and can be used as an effective therapeutic agent for the treatment or prevention of liver diseases such as liver fibrosis, liver cirrhosis, liver cancer or hepatitis and the like, and is also an excellent drug that can replace ursodeoxycholic acid which is a widely used therapeutic agent for liver diseases in the past.

Description

technical field [0001] The invention relates to a compound preparation for treating liver disease or improving curative effect, the compound preparation is formed by colchicine and metformin as main active ingredients. Specifically, it relates to a pharmaceutical medicine that mixes the drug colchicine, which is known to have a liver-protecting effect, with metformin, which is mainly used for diabetic disorders, and has better pharmacological effects than traditional drugs administered alone. The composition is a pharmaceutical composition for improving the curative effect of liver diseases prepared after specifically limiting the contents of the various drugs. Background technique [0002] The liver plays a central role in the metabolism of substances in vitro and in vivo, and is a biological organ that continuously undergoes enzymatic reactions and energy metabolism. At present, hepatitis, liver cirrhosis and liver cancer, like circulatory system diseases, account for the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/165A61K31/155A61P1/16A61P35/00A61P31/14A61P31/20
CPCA61K31/165A61K31/155A61P1/16A61P35/00A61P31/14A61P31/20A61K2300/00
Inventor 尹胄晧车旺祚咸宣娥
Owner 艾斯生物医药株式会社
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