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Chinese patent medicine for treating hoarseness disease and preparation method thereof

A technology for Chinese patent medicine and laryngopharyngeal ulcer, which is applied in the field of Chinese patent medicine for treating laryngopharynx and its preparation, can solve the problems of short drug effect time, increase the number of times of taking medicine, etc., and achieve the effects of prolonging the drug effect time, simplifying the traditional Chinese medicine formula, and optimizing the curative effect.

Inactive Publication Date: 2020-11-10
MUDANJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the drug has a short duration of action, it is necessary to increase the number of doses in order to maintain a certain blood concentration

Method used

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  • Chinese patent medicine for treating hoarseness disease and preparation method thereof
  • Chinese patent medicine for treating hoarseness disease and preparation method thereof
  • Chinese patent medicine for treating hoarseness disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] First mix 12g wood butterfly extract, 5g bellflower extract, 3g isatidis extract, 2g reed rhizome extract and 1g pinellia extract, and then pulverize to obtain the active ingredients of traditional Chinese medicine, then mix 25g chitosan, 15g microcrystalline cellulose, 8g sodium carboxymethylcellulose and 1g magnesium stearate are mixed and pulverized to obtain preparation auxiliary materials, then 15g of active ingredients of traditional Chinese medicine and 85g preparation auxiliary materials are mixed, passed through a 100-mesh sieve, and finally compressed into a specification of 0.15g / tablet by dry powder direct molding method tablet.

Embodiment 2

[0036] Example 2 is the same as the tablet preparation method of Example 1, except that microcrystalline cellulose is replaced by compressible starch.

[0037] First mix 12g wood butterfly extract, 5g bellflower extract, 3g isatidis extract, 2g reed rhizome extract and 1g pinellia extract, and then crush to obtain the active ingredients of traditional Chinese medicine, then mix 25g chitosan, 15g compressible starch, 8g sodium carboxymethylcellulose and 1g magnesium stearate are mixed and pulverized to obtain preparation auxiliary materials, then 15g of active ingredients of traditional Chinese medicine and 85g preparation auxiliary materials are mixed, passed through a 100-mesh sieve, and finally compressed into a specification of 0.15g / tablet by dry powder direct molding method tablet.

Embodiment 3

[0039] The tablet preparation method of embodiment 3 is the same as that of embodiment 1, and the difference is that chitosan is replaced by β-cyclodextrin.

[0040] First mix 12g wood butterfly extract, 5g bellflower extract, 3g isatidis extract, 2g reed rhizome extract and 1g pinellia extract, and then crush to obtain the active ingredients of traditional Chinese medicine, then mix 25g β-cyclodextrin, 15g microcrystalline cellulose , 8g sodium carboxymethyl cellulose and 1g magnesium stearate are mixed and pulverized to obtain preparation auxiliary materials, then 15g of active ingredients of traditional Chinese medicine and 85g preparation auxiliary materials are mixed, passed through a 100 mesh sieve, and finally compressed into a specification of 0.15g / sliced ​​tablet.

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Abstract

The invention discloses a Chinese patent medicine for treating hoarseness disease and a preparation method thereof, and relates to the technical field of Chinese patent medicine processing; the Chinese patent medicine comprises traditional Chinese medicine effective components and preparation auxiliary materials; the traditional Chinese medicine effective components comprise oroxylum indicum extract, platycodon grandiflorum extract, isatis root extract, reed rhizome extract and pinellia ternate extract. The preparation auxiliary materials consist of a sustained release agent, a filling agent,an adhesive and a lubricating agent. The traditional Chinese medicine extracts are directly used as a processing raw material, the preparation process of the traditional Chinese medicine extracts is omitted, and the traditional Chinese medicine extracts are selected according to the scientific compatibility principle of monarch, minister, assistant and guide, so that the technical effects of simplifying the traditional Chinese medicine formula and ensuring the curative effect are achieved. By adding the sustained-release agent, the tablet is endowed with a controllable sustained-release effect, the drug effect time is prolonged, the bioavailability of the drug is improved, and the curative effect is optimized.

Description

Technical field: [0001] The invention relates to the technical field of Chinese patent medicine processing, in particular to a Chinese patent medicine for treating sore throat and a preparation method thereof. Background technique: [0002] Laryngitis is a throat disease with hoarseness as the main clinical manifestation caused by exogenous wind pathogens or visceral disorders. Clinically, it is often accompanied by symptoms such as itchy throat, dryness and slight pain. Teachers, announcers, salespersons, etc. who use a lot of voice are prone to suffer from this disease. [0003] Western medicine often adopts local aerosol inhalation anti-inflammatory treatment or oral antibiotic treatment, but there are many adverse reactions and high recurrence frequency, and aerosol inhalation anti-inflammatory treatment is also limited by equipment and time. At present, there are many Chinese patent medicines clinically used to treat sore throat, such as Huang's Xiangsheng Pills, etc....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K47/32A61P11/04
CPCA61K36/185A61K36/195A61K36/315A61K36/346A61K36/8888A61K36/899A61K47/32A61P11/04A61K2300/00
Inventor 王乐秋张立晨孙凯王莹宁燕董建将郝艳坤马秀凤隋萍萍齐悦
Owner MUDANJIANG MEDICAL UNIV
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