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A kind of hydrophilic polypeptide monolayer film and its preparation method and application

A single-layer film and hydrophilic technology, applied in the field of natural polymers, can solve the problems of limiting the application of polypeptide molecules, achieve the effects of small thickness, reduce restenosis of cardiovascular and cerebrovascular vessels, and long release time

Active Publication Date: 2021-12-14
QILU UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Due to the complexity of the structure of natural biological macromolecules, there are few reports on the chemical properties of the surface of the monolayer membrane of polypeptide molecules, which limits the application of polypeptide molecules

Method used

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  • A kind of hydrophilic polypeptide monolayer film and its preparation method and application
  • A kind of hydrophilic polypeptide monolayer film and its preparation method and application
  • A kind of hydrophilic polypeptide monolayer film and its preparation method and application

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Embodiment 1

[0050] A method for preparing a polypeptide monolayer film, comprising the following steps:

[0051] (1) Prepare 50 mL of collagen peptide solution with a concentration of 4% wt: accurately weigh 100 mL of collagen peptide in a three-necked flask, accurately measure deionized water, pour the deionized water into the three-necked flask, and swell at room temperature for 0.5 h. Put the three-neck flask in a water bath at 50±1°C, heat and stir for 2 hours to dissolve it completely, then adjust the pH of the solution to 10.00±0.02 with 2mol / L sodium hydroxide, and stabilize it in the water bath for 0.5 hours.

[0052] (2) Add surfactant STS to the above-mentioned collagen polypeptide solution to obtain a collagen polypeptide-STS mixed solution, the concentration of STS in the mixed solution is 8.02mmol / L (at 50°C, the mass fraction of STS in the mixed solution is 6%) ; Stable in a water bath for 6h for later use.

[0053] (3) Cut a rectangular titanium sheet with a size of 1cm×1c...

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Abstract

The invention provides a hydrophilic polypeptide monolayer film and its preparation method and application. The polypeptide is composed of a molecular weight of (1.48±0.2)×10 5 g / mol of polypeptide molecules, the thickness of the monolayer film is 7.6±0.1nm, the exposure of primary amino groups on the surface of the membrane is 6.03±0.1%, and the Zeta potential of the polypeptide monolayer film is -2.76±0.1mV; the film The contact angle is 29±1°. The characteristics of the polypeptide monolayer film of the present invention as a drug carrier are uniform structure, small monolayer film thickness, good hydrophilicity and drug adsorption, and tight and stable combination with the metal stent. The prepared coated stent Uniform and stable, there will be no problems such as blockage, entanglement, easy falling off, local over-thickness, etc. It carries drugs for a long release time, which can effectively reduce the incidence of cardiovascular and cerebrovascular restenosis.

Description

technical field [0001] The invention belongs to the field of natural polymers, and relates to a polypeptide monolayer film and its preparation method and application, in particular to a hydrophilic polypeptide monolayer film, its preparation method and its application. Background technique [0002] Collagen peptide is a water-soluble protein obtained by chemical thermal degradation of collagen. It is one of the most commonly used biopolymers due to its excellent biocompatibility, plasticity, viscosity, abundance and low cost. As a biodegradable and renewable resource, collagen peptides are widely used in the preparation of medical materials, bionic materials, packaging and coating materials. Bio-immobilized coatings are often used in the field of biomimetic scaffolds to solve the problem of carrying biomolecules, drug molecules, synthetic polymers or small organic molecules such as enzymes, lactose, and polydopamine. The loading capacity is easy to precisely control and so...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/02A61L31/10A61L31/14A61L31/16
CPCA61L31/022A61L31/10A61L31/14A61L31/16A61L2300/416A61L2300/606A61L2420/02A61L2420/08C08L89/00C08L79/02
Inventor 许静张震李天铎马慧君班青
Owner QILU UNIV OF TECH
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