Preparation method of degradable tissue glue based on polylactic acid and polycaprolactone copolymer

Abstract

The invention relates to the technical field of tissue glue manufacturing, in particular to a preparation method of degradable tissue glue based on polylactic acid and polycaprolactone copolymer. Thepreparation method comprises the following steps: S1, synthesizing PCL / PLA copolymer through bulk ring-opening polymerization reaction of epsilon-caprolactone and DL-lactide under high-temperature and vacuum conditions; and S2, purifying the PCL / PLA copolymer. The copolymer has a double-sided bonding effect in actual use, has good biocompatibility, can play a bonding role within a certain time,has good viscoelasticity and holding power, and has high peel strength. The copolymer has a double-sided bonding effect in actual use, has good biocompatibility, can play a bonding role within a certain time, and has good viscoelasticity and holding power, and high peel strength.

Description

technical field [0001] The invention relates to the technical field of tissue glue production, in particular to a preparation method for degradable tissue glue based on polylactic acid and polycaprolactone copolymer. Background technique [0002] Biomaterials are a class of materials used for diagnosis, treatment, and repair, replacement, and reconstruction of body cells, tissues, and organs. They are widely used in the preparation of medical devices, organ repair, artificial organs, interventional medical products, and drug release systems. It is directly related to people's health and quality of life, and has important social significance and economic benefits. In 2019, the world medical device market is estimated to exceed 450 billion US dollars, of which biological materials and products account for about half. With the aging of the population, the improvement of people's requirements for the quality of life, and the need for new medical technologies, the international ...

AI Technical Summary

Problems solved by technology

However, Histoacryl, the tissue glue currently used clinically, has certain toxicity and is not biodegradable.

[0006] The tissue glue that has been used clinically at present is Histoacryl glue (monomer N-butyl-2-acrylic acid cyanide) developed by Braun Medical Group in Germany. After contacting with human tissue fluid, it quickly polymerizes and becomes a multimer. The multimer can form a solid film to make the wound edges tightly bonded together to form a strong and reliable wound closure. However, the toxicity of cyanoacrylate materials Limits the application of this type of tissue glue in vivo, so it is limited to the closure of skin wounds[6,7]

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