A kind of dexamethasone oral fast-dissolving film and preparation method thereof
A technology of dexamethasone and instant film, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of poor water solubility and difficulty of oral instant film, and achieve disintegration speed Fast, good compliance, good for dissolution and absorption
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Embodiment 1
[0049] A dexamethasone oral fast-dissolving film, the oral fast-dissolving film is composed of the following components by mass percentage:
[0050] Dexamethasone 1.95%
[0051] PUVS 9.77%
[0052] Film-forming material Pullulan 78.13%
[0053] Propylene Glycol 6.25%
[0054] Sodium alginate 3.9%.
[0055] The preparation method of the dexamethasone oral instant film of the above-mentioned formula, comprises the following steps:
[0056] (1) Preparation of conjugate PUVS: Dissolving pullulan in DMSO to obtain a pullulan solution for later use, 4-dimethylaminopyridine DMAP, 1-(3-dimethylaminopyridine DMAP, 1-(3-dimethypyridine) in a molar ratio of 1:1.2:1 Methylaminopropyl)-3-ethylcarbodiimide hydrochloride EDC and vitamin E succinate VES were dissolved in DMSO and stirred and activated at room temperature for 1 h, and then slowly added dropwise to the aforementioned pullulan solution. The molar ratio of pullulan to VES was 100:1, and the reaction was continued to stir at ...
Embodiment 2
[0063] A dexamethasone oral fast-dissolving film, the oral fast-dissolving film is made up of the following components by mass percentage:
[0064] Dexamethasone 1%
[0065] PUVS 6.3%
[0066] Film-forming material 90%
[0067] Macrogol 4001.8%
[0068] Croscarmellose sodium 0.9%.
[0069] The preparation method of the dexamethasone oral instant film of the above-mentioned formula, comprises the following steps:
[0070] (1) Preparation of conjugate PUVS: Dissolving pullulan in DMSO to obtain a pullulan solution for later use, 4-dimethylaminopyridine DMAP, 1-(3-dimethylaminopyridine DMAP, 1-(3-dimethypyridine) in a molar ratio of 1:1.2:1 Methylaminopropyl)-3-ethylcarbodiimide hydrochloride EDC and vitamin E succinate VES were dissolved in DMSO and stirred and activated at room temperature for 1 h, and then slowly added dropwise to the aforementioned pullulan solution. The molar ratio of pullulan to VES was 150:1, and the reaction was continued to stir at room temperature ...
Embodiment 3
[0074] A dexamethasone oral fast-dissolving film, the oral fast-dissolving film is made up of the following components by mass percentage:
[0075] Dexamethasone 5%
[0076] PUVS 15%
[0077] Film-forming material 64%
[0078] Glycerin 6.4%
[0079] Sodium Carboxymethyl Starch 9.6%.
[0080] The preparation method of the dexamethasone oral instant film of the above-mentioned formula, comprises the following steps:
[0081] (1) Preparation of conjugate PUVS: Dissolving pullulan in DMSO to obtain a pullulan solution for later use, 4-dimethylaminopyridine DMAP, 1-(3-dimethylaminopyridine DMAP, 1-(3-dimethypyridine) in a molar ratio of 1:1.2:1 Methylaminopropyl)-3-ethylcarbodiimide hydrochloride EDC and vitamin E succinate VES were dissolved in DMSO and stirred and activated at room temperature for 1 h, and then slowly added dropwise to the aforementioned pullulan solution. The molar ratio of pullulan to VES was 30:1, and the reaction was continued to stir at room temperature...
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