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Method of screening atomization device suitable for beta2 receptor agonist

An atomization device and β2 receptor technology, applied in the field of medicine, can solve the problems of inability to effectively maintain the treatment effect of patients, error-prone, different delivery doses, etc., and achieve the best drug delivery effect

Pending Publication Date: 2020-09-01
SHANGHAI FANGYU HEALTH PHARMA TECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] β2 receptor agonist drugs as bronchodilators are the drugs of choice for the treatment of airway spasm. There are various nebulizers on the market, but it is not known whether the nebulizers are really suitable for this type of drug. The same nebulizer The delivery dose of different drugs will also be different. Regardless of short-acting or long-acting drugs, if the required delivery dose cannot be achieved, the therapeutic effect on patients cannot be effectively maintained.
Although it is straightforward to detect the effective inhalation dose of the atomization device, the cost of the device is relatively high because the inhalation effective dose requires the use of a breathing simulation device, and after collection by this device, high performance liquid chromatography is still required for detection, which is cumbersome and easy to operate. go wrong

Method used

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  • Method of screening atomization device suitable for beta2 receptor agonist
  • Method of screening atomization device suitable for beta2 receptor agonist
  • Method of screening atomization device suitable for beta2 receptor agonist

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Select different compressed air atomization devices (i.e. atomization device 1 (Jiaruikang), atomization device 2 (Bairui), atomization device 3 (Yuyue)) and use the detection method of the aforementioned compressed air atomization device to measure the fog See Table 1 for the effect of granules on the nebulization effect of β2 receptor agonist (formoterol inhalation solution, specification: 20 μg / 2ml).

[0055] Table 1 Influence of the atomized particles of the compressed air atomization device on the atomization effect

[0056]

[0057]

[0058] The particle size ratio of the atomized particles of 1-5 μm in the atomization device 1 is 34.2%, resulting in an effective inhalation amount of only 1.1 μg. The particle size ratio of the atomized particles of 1-5 μm in the atomization device 3 is 78.3%, resulting in an effective inhalation amount of only 1.6 μg. The particle size ratio of the atomized particles of 1-5 μm in the atomizing device 2 is within the scope o...

Embodiment 2

[0060] Select different vibrating screen atomization devices (atomization device 1 (Oxygen), atomization device 2 (Raffles), atomization device 3 (Yuyue)) and use the detection method of the aforementioned vibrating screen atomization device to measure the atomized particles See Table 2 for the effect on the atomization effect of the β2 receptor agonist (formoterol inhalation solution, specification: 20 μg / 2ml).

[0061] Table 2 Influence of the atomized particles of the vibrating screen atomization device on the atomization effect

[0062]

[0063] The particle size ratio of the atomized particles of 1-5 μm in the atomization device 1 is 30.7%, resulting in an effective inhalation amount of only 1.3 μg. The particle size ratio of the atomized particles of 1-5 μm in the atomization device 3 is 76.4%, resulting in an effective inhalation amount of only 1.5 μg. The particle size ratio of the atomized particles of 1-5 μm in the atomizing device 2 is within the scope of the pr...

Embodiment 3

[0065] Select different vibrating sieve atomizers (atomization device 1 (Raffles) and atomization device 2 (Yuyue)) to determine β2 receptor agonists (formoterol inhalation Solution, specification: 20 μ g / 2ml) the value of volume average particle diameter specific surface area average particle diameter, observe atomized particle shape by electron microscope, the result is shown in Table 3.

[0066] Table 3 volume average particle diameter specific surface area average particle diameter result

[0067]

[0068] The ratio result of atomization device 1 is less than 3, and the ratio result of atomization device 2 is greater than 3, from figure 1 It can be seen from the electron microscope image that the particles with smaller values ​​(atomization device 1) are spherical in shape, and the particles with larger values ​​are spherical in shape.

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Abstract

The invention relates to a method for screening an atomization device suitable for a beta2 receptor agonist. The method comprises the following steps: (1) detecting the particle size ratio, the volumeaverage particle size and the surface area average particle size of 1-5[mu]m atomization particles in an atomization device to be screened; (2) detecting the concentration of the electrolyte solution; (3) selecting an atomization device which simultaneously meets the following conditions a) and b): a) the ratio of the particle size of the 1-5[mu]m atomization particles is 50-70%, the ratio of thevolume average particle size to the surface area average particle size is less than and / or equal to 3, and b) the concentration of the electrolyte solution is 0.2-1% w / v.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a method for screening an atomizing device suitable for β2 receptor agonists. Background technique [0002] According to the latest COPD epidemiological survey, the prevalence of COPD among people aged 20-39 in my country is 2.1%, that of people over 40 years old is 13.7%, and that of people over 70 years old is as high as 35.5%. Based on this prevalence calculation, there are more than 100 million COPD patients in my country. [0003] The existing treatment methods for COPD mainly include oral administration, injection and inhalation, etc. However, both oral administration and injection will send the medicine to the blood first and then to the lungs, so the efficiency of drug treatment is often low. With the development of medicine and preparation science, and the in-depth understanding of lung function and pulmonary diseases such as asthma and chronic obstructive pulmonary di...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N15/02
CPCG01N30/02G01N15/0205G01N2015/0277Y02A50/30
Inventor 金方徐博淳闻聪
Owner SHANGHAI FANGYU HEALTH PHARMA TECH CO LTD
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