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Drug for treating heart disease and detection method

A detection method, heart disease technology, applied in the direction of biochemical equipment and methods, testing pharmaceutical preparations, microbiological determination/inspection, etc., can solve the problem of low detection accuracy, stability and repeatability, simple detection method, undisclosed and other issues, to achieve the effect of ensuring the safety, stability and repeatability of the drug, and ensuring the quality of the drug

Active Publication Date: 2021-02-19
内蒙古凯蒙药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the detection methods in the above-mentioned patents are relatively incomplete, and the detection methods of other indicators are not disclosed. At the same time, the precision or repeatability of identification or detection is relatively poor
As for Sanwei Sandalwood Capsules, so far, the relevant detection methods in the "Chinese Pharmacopoeia" or other relatively simple and single detection methods are still generally used in the industry
[0004] In view of the problems existing in the prior art that the detection method is simple and single, and the accuracy, stability and repeatability of the detection are low, it is urgent to find a detection method for heart disease drugs, so as to ensure the quality and safety of drugs

Method used

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  • Drug for treating heart disease and detection method
  • Drug for treating heart disease and detection method
  • Drug for treating heart disease and detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] A detection method for a drug for the treatment of heart disease, the drug is Sanwei Sandalwood Capsule, the detection method includes character, identification, inspection, extract and content determination, specifically:

[0053] (1) Properties: Take an appropriate amount of the medicine, look at it in a bright place with natural light, and smell and taste the medicine;

[0054] (2) Identification: including identification of sandalwood oil and identification of nutmeg;

[0055] Among them, the identification of sandalwood oil is as follows: take 4 g of the drug content, extract twice with ether, 10 mL each time, combine the two extracts, evaporate to about 2 mL, and use it as the test solution. In addition, the reference medicinal material of sandalwood was taken, and the volatile oil was extracted according to the method of 2204 Volatile Oil Determination Method of the 2015 edition of the Chinese Pharmacopoeia, and ether was added to make a solution containing 0.1 m...

Embodiment 2

[0069]The difference with Example 1 is that in the identification of nutmeg, the developing agent is chloroform-benzene whose volume ratio is 4:5, and the volume ratio of sulfuric acid-methanol solution is 1:1; , after drying, heated to 30°C for 10min, then heated to 45°C for 10min, then heated to 65°C for 5min and then cooled to 25°C; in the identification of sandalwood oil, petroleum oil with a volume ratio of 0.8:3:1.2:0.1 was used Ether-n-hexane-ethyl formate-formic acid is developed as a developing agent, taken out, dried, heated to 28°C for 10min, and then cooled to 25°C; in the identification of jujube content, the pretreatment step is to cool the contents to Keep at 13°C for 0.8h, then cool down to 10°C, hold for 10min, and then dry.

Embodiment 3

[0071] The difference with Example 1 is that in the identification of nutmeg, the developing agent is chloroform-benzene whose volume ratio is 6:5, and the volume ratio of sulfuric acid-methanol solution is 1:2; , after drying, heated to 38°C for 8min, then heated to 60°C for 5min, then heated to 68°C for 5min and then cooled to 25°C; in the identification of sandalwood oil, petroleum oil with a volume ratio of 1.2:3:1.6:0.1 was used Ether-n-hexane-ethyl formate-formic acid was developed as a developing agent, taken out, dried, heated to 28°C for 15min, and then cooled to 22°C; in the identification of jujube content, the pretreatment step was to cool the contents to Hold at 16°C for 1 hour, then cool down to 12°C, hold for 15 minutes, and then dry.

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Abstract

The invention provides a drug for treating heart disease and a detection method, and relates to a detection method of the drug. The drug is Sanwei Sandalwood Capsule. Among them, the identification includes the identification of sandalwood oil and the identification of nutmeg. The inspection includes the inspection of the difference in filling volume, disintegration time limit, water content, and microbial limit. The content determination involves the determination of the content of jujube and the content of total volatile oil. In the present invention, by optimizing the methods of identification and content determination, the detection method has higher accuracy, stability and repeatability than conventional detection methods, thereby further ensuring the drug quality of Sanwei Sandalwood Capsules and ensuring Medication safety.

Description

technical field [0001] The invention relates to a drug detection method, in particular to a drug for treating heart disease and a detection method. Background technique [0002] Heart disease is a relatively common type of circulatory system disease. The circulatory system consists of the heart, blood vessels and neurohumoral tissues that regulate blood circulation. Circulatory system diseases are also called cardiovascular diseases, including diseases of all the above-mentioned tissues and organs. In recent years, with the improvement of living standards and the accelerated pace of life, environmental factors, dietary factors and other conditions have caused more and more health risks, and the incidence of cardiovascular disease has gradually increased, becoming one of the main factors threatening human health. one. According to statistics, about 17.5 million people die of heart disease every year in the world, accounting for 30% of all deaths, and the number of cardiovasc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/15G01N30/90G01N30/02C12Q1/04
CPCC12Q1/04G01N30/02G01N30/90G01N33/0001G01N33/15
Inventor 郝秀清
Owner 内蒙古凯蒙药业有限公司
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