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High-acid-resistance vitamin A product and preparation method thereof

A vitamin and product technology, applied in the field of high acid-resistant vitamin A products and their preparation, can solve the problems of high pressure homogenization temperature, difficult industrialization, complicated processes, etc., and achieves improved acid resistance and stability, improved stability and acid resistance the effect of reducing the degree of degradation

Active Publication Date: 2020-08-18
INNOBIO CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] CN200710192023.7 discloses a method for preparing vitamin A and vitamin E nanosphere / microsphere double embedding system, using Tween-80 and monoglyceride as emulsifier, and octenyl succinic esterified starch as wall material , after high-speed shearing and high-pressure homogenization, vitamin A nanoemulsions were obtained, and then spray-dried to obtain finished products, but the high-pressure homogenization temperature was relatively high, and the spray-drying method adopted was not conducive to tablet production
[0007] A preparation method of vitamin E microcapsules is disclosed in CN20081024267.3. Soybean lecithin and Tween-80 are used as composite emulsifiers to obtain vitamin E microcapsule products through high-pressure emulsification and centrifugal spray drying. The emulsifier addition amount is 1.5 The dosage of %~1.75% is not allowed to be used in some countries and regions. At the same time, high-speed shearing and high-pressure homogenization are used many times. The complicated process is not conducive to industrial production
[0008] CN200880025234.4 discloses tabletable preparations of lipophilic health ingredients. In the production process of vitamin A tableted microcapsules, cornstarch needs to be cooled and sieved, and then dried at room temperature. The complex process is not conducive to industrial production
[0009] In view of the above various vitamin A microcapsule products, the preparation process is complicated, the industrialization is difficult, and the application characteristics are not clear. A new preparation method for vitamin A microcapsules is needed to better solve the above problems

Method used

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  • High-acid-resistance vitamin A product and preparation method thereof
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  • High-acid-resistance vitamin A product and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Aqueous phase preparation: 40.4 g of octenyl succinic mono-arabic acid ester and 14.8 g of glucose syrup were dissolved in 100 g of water, and 0.4 g of ascorbic acid and 1.2 g of sodium ascorbate were added.

[0041] Preparation of the oil phase: 20.8 g of vitamin A acetate and 2.4 g of BHT were stirred and dissolved at 60-65° C. in the dark.

[0042] After the two phases are mixed, fully stir, disperse and emulsify for 30 minutes, during which the temperature is maintained at 60-65°C to obtain an emulsion.

[0043] Homogenize the emulsion under high pressure of 40±2Mpa.

[0044] The emulsified liquid is placed in a constant temperature tank, the temperature is controlled at 60-65° C., spray-dried, spray-dried, then fluidized-dried and polished to obtain vitamin A acetate microcapsules.

Embodiment 2

[0046]Aqueous phase preparation: 38.2 g of octenyl succinic mono-arabic acid ester and 15.2 g of glucose syrup were dissolved in 100 g of water, and 0.6 g of ascorbic acid and 0.8 g of sodium ascorbate were added.

[0047] Preparation of the oil phase: 23.2g of vitamin A palmitate and 2.0g of BHT were stirred and dissolved at 60-65°C in the dark.

[0048] After the two phases are mixed, fully stir, disperse and emulsify for 30 minutes, during which the temperature is maintained at 60-65°C to obtain an emulsion.

[0049] Homogenize the emulsion under high pressure of 50±2Mpa.

[0050] The emulsified solution is placed in a constant temperature bath, the temperature is controlled at 60-65° C., spray-dried, spray-dried, then fluidized-dried and polished to obtain vitamin A palmitate microcapsules.

Embodiment 3

[0052] Preparation of the aqueous phase: 43.5 g of octenyl succinic acid mono-arabic acid and 16.0 g of glucose syrup were dissolved in 100 g of water, and 0.5 g of ascorbic acid and 1.5 g of sodium ascorbate were added.

[0053] Oil phase preparation: vitamin A 15.5g and BHT 3.0g were stirred and dissolved at 60-65°C in the dark.

[0054] After the two phases are mixed, fully stir, disperse and emulsify for 30 minutes, during which the temperature is maintained at 60-65°C to obtain an emulsion.

[0055] The emulsion is subjected to high pressure at 30±2Mpa.

[0056] The emulsified solution is placed in a constant temperature tank, the temperature is controlled at 60-65° C., spray-dried, spray-dried, then fluidized-dried and polished to obtain vitamin A microcapsules.

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Abstract

The invention discloses a high-acid-resistance vitamin A product and a preparation method thereof. The high-acid-resistance vitamin A product is prepared from the following raw materials in parts by weight: 10-40 parts of vitamin A substance, 30-60 parts of an embedding wall material, 5-35 parts of a filling material and 0-8 parts of an antioxidant. The vitamin A substance is selected from vitaminA, vitamin A acetate and palmitate. According to the invention, the defects of the vitamin A raw material in application are overcome, and the stability and acid resistance of the vitamin A ester microencapsulated product are greatly improved through the combined use of the embedding wall material, the filling material and the antioxidant. High-temperature melting and high-speed shearing processtreatment is not needed, the degradation degree of the raw materials in the processing process can be effectively reduced, the safe and environment-friendly effects are achieved, the preparation process is simple, and industrial production is facilitated.

Description

technical field [0001] The invention belongs to the technical field of preparation of functional additives, and specifically designs a high acid-resistant vitamin A product and a preparation method thereof. Background technique [0002] Vitamin A, also known as retinol or anti-eye dryness factor, is an unsaturated monohydric alcohol with an alicyclic ring. Its pure product is light yellow crystal with a molecular weight of 286.46g / mol. Vitamin A is a fat-soluble vitamin, insoluble in glycerin and water, and easily soluble in chloroform, ether, petroleum ether, absolute ethanol and vegetable oil. Vitamin A is an essential nutrient element for normal human growth and development, bone formation, normal vision and immune system maintenance. It has the functions of anti-lipid peroxidation, enhancing immunity, enhancing anti-infection, regulating fat storage, and improving iron deficiency anemia. Vitamin A deficiency will increase the incidence of various infectious diseases, re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/42A61K47/26A61K47/36A61K47/10A61K31/07
CPCA61K9/5057A61K9/5015A61K9/5036A61K31/07
Inventor 马宇骥李倩陈碧聪耿佳鑫李晓贺吴文忠
Owner INNOBIO CORP LTD
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