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Ciclopirox olamine ointment and preparation method thereof

A technology of ciclopirox amine cream and ciclopirox amine, which is applied in the directions of ointment delivery, pharmaceutical formulation, emulsion delivery, etc., can solve the problems of poor spreadability, slight odor, rough composition, etc., and achieves easy absorption, Good bactericidal effect, good therapeutic effect

Pending Publication Date: 2020-08-14
浙江圣华药业有限公司
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] Ciclopirox olamine is one of the drugs for the treatment of this common disease. As a topical antifungal drug, ciclopirox olamine cream currently on the market has relatively rough ingredients, poor drawing properties, slight odor, and poor viscosity. Uniform spread coverage without utilizing the skin surface

Method used

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  • Ciclopirox olamine ointment and preparation method thereof
  • Ciclopirox olamine ointment and preparation method thereof

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preparation example Construction

[0023] A preparation method of ciclopirox olamine emulsifiable cream, the method comprises the following steps:

[0024] S1. Weigh an appropriate amount of purified water and put it in the water phase pot, add the prescribed amount of propylene glycol, sodium lauryl sulfate, ethylparaben and ciclopirox olamine under stirring, dissolve and heat up to 75°C, stir Keep warm for 10 minutes and set aside;

[0025] S2. Put stearic acid, stearyl alcohol, glyceryl monostearate, liquid paraffin, and white petrolatum in the oil phase pot, heat until melting, and control the melting temperature at 80°C; 10min; standby;

[0026] S3. Turn on the heating to make the temperature of the emulsification pot reach 80°C, control the vacuum degree in the emulsification pot within 0.03Mpa, pump the materials in the water phase pot into the emulsification pot, stir, and then pump the materials in the oil phase pot to emulsification In the pot, then under the condition of 80°C, fully stir and emulsi...

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Abstract

The invention provides a ciclopirox olamine ointment and a preparation method thereof, and belongs to the technical field of chemical agents. Each 1000 g of the ciclopirox olamine ointment comprises the following raw materials by weight: 8-12 g of ciclopirox olamine, 50-70 g of stearic acid, 50-70 g of glycerin monostearate, 50-70 g of albolene, 80-120 g of propylene glycol, 10-20 g of sodium dodecyl sulfate, 0.5-1.2 g of ethylparaben, 50-70 g of octadecanol, 80-100 g of liquid paraffin and the balance of purified water. The ciclopirox olamine ointment has the advantages of good bactericidal effect, better softness and better viscosity.

Description

technical field [0001] The invention belongs to the technical field of chemical medicaments, in particular to a ciclopirox olamine cream and a preparation method thereof. Background technique [0002] Fungal infectious diseases are divided into four categories according to the parts where fungi invade the human body: superficial mycosis, skin mycosis, subcutaneous tissue mycosis and systemic mycosis. Worldwide, dermatophytosis is the most common fungal disease with a high incidence rate and is one of the common diseases that plague human health. [0003] Ciclopirox olamine is one of the drugs for the treatment of this common disease. As a topical antifungal drug, ciclopirox olamine cream currently on the market has relatively rough ingredients, poor drawing properties, slight odor, and poor viscosity. Does not utilize even application of skin surface for coverage. Contents of the invention [0004] The purpose of the present invention is to exist above-mentioned problem ...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/4412A61K47/06A61K47/14A61K47/10A61K47/20A61P17/00A61P31/10
CPCA61K9/06A61K9/0014A61K31/4412A61K47/06A61K47/14A61K47/10A61K47/20A61P17/00A61P31/10
Inventor 张玲丽
Owner 浙江圣华药业有限公司
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