A kind of hydrogel of slow-release chlorine dioxide and preparation method thereof

Abstract

The invention relates to the technical field related to the slow release of chlorine dioxide, and more specifically, the invention provides a hydrogel for slow release of chlorine dioxide and a preparation method thereof. The first aspect of the present invention provides a slow-release chlorine dioxide hydrogel, its preparation materials include chlorine dioxide, polyglutamic acid solution grafted with tyramine, hyaluronic acid solution grafted with cysteamine, horseradish Peroxidase, hydrogen peroxide, and alcohols; wherein, the alcohols include diols with a relative molecular weight of 2000-5000 and trihydric alcohols with a relative molecular weight of 80-300. The present invention uses tyramine-grafted polyglutamic acid and cysteamine-grafted hyaluronic acid to form an interpenetrating network structure in the hydrogel system, effectively improving the mechanical strength of the hydrogel; Under the synergistic effect of alcohol and trihydric alcohol, a low-temperature and antifreeze hydrogel system suitable for the slow release of chlorine dioxide is formed, which avoids the problem of limited use conditions due to the easy freezing of chlorine dioxide solution.

Description

technical field [0001] The present invention relates to the technical field related to the slow-release of chlorine dioxide, more specifically, the invention provides a kind of hydrogel of slow-release chlorine dioxide and preparation method thereof. Background technique [0002] Chlorine dioxide is an effective antiviral chemical reagent. Chlorine dioxide has a broad-spectrum antimicrobial effect, and has no pain, teratogenic, or mutagenic effects on higher animal cells. It also has the effect of eliminating formaldehyde and has a high degree of safety. , is listed by the World Health Organization as an Al-level broad-spectrum, safe, and highly effective disinfectant, and is respected as the fourth-generation disinfectant. However, the traditional chlorine dioxide slow-release gel is only suitable for the room temperature environment with high temperature. In the low-temperature environment, due to reasons such as the freezing of the chlorine dioxide solution, the slow-rele...

AI Technical Summary

Problems solved by technology

However, the traditional chlorine dioxide slow-release gel is only suitable for the room temperature environment with high temperature. In the low-temperature environment, due to the freezing of the chlorine dioxide solution and other reasons, the slow-release gel cannot release antiviral effective substances, and the applicability of the low-temperature environment Poor, so the lack of suitable carriers and formulations limits its application

[0003] The gels of slow-release antibacterial agents mostly use artificially synthesized polymer materials as carriers, but the materials themselves have many synthesis steps, poor environmental economy, and potential biotoxicity when used in the medical field

Moreover, the traditional gel carrier is only suitable for room temperature environment. Due to freezing and other reasons in low temperature environment, the sustained release of drugs cannot be achieved, or the sustained release effect is poor. The emergence of natural polymer-based biohydrogels is a solution to this problem. It provides a better solution, its biocompatibility is good, and it can be degraded and absorbed in nature. It can also be used in different clinical conditions in combination with drugs, showing broad application prospects, but it may have poor mechanical properties during use. Good, poor injectability and other disadvantages

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