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Azelaic acid/titanium dioxide hybrid composite material and preparation method thereof

A kind of azelaic acid, composite material technology, applied in cosmetic preparations, titanium organic compounds, cosmetics and other directions, to achieve the effect of improving sunscreen ability, enhancing structural stability, and ensuring orderly dispersion

Inactive Publication Date: 2020-08-11
SICHUAN SIPO CHEMICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the matrix of pharmaceutical preparations or cosmetic raw materials is mostly oily, and there are problems such as how to improve the antibacterial and dispersibility of nano-titanium dioxide in actual use, which is also an urgent problem to be solved for external skin preparations and nano-titanium dioxide for cosmetics.

Method used

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  • Azelaic acid/titanium dioxide hybrid composite material and preparation method thereof
  • Azelaic acid/titanium dioxide hybrid composite material and preparation method thereof
  • Azelaic acid/titanium dioxide hybrid composite material and preparation method thereof

Examples

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Embodiment 1

[0024] A preparation method of rhododendronic acid / titanium dioxide hybrid composite material, comprising the following steps:

[0025] Step 1. Add 350mL of rutile nano-titanium dioxide aqueous solution with a mass concentration of 0.8% in the reaction vessel, stir until uniformly dispersed, then add 2.8mL of 50wt% sodium hydroxide aqueous solution dropwise, and heat up at a rate of 25°C / h after the addition is completed to 70°C, react for 12 hours; after the reaction is completed, cool down to below 60°C, wash and filter with 3 times of water, and obtain intermediate product of hydroxylated titanium dioxide;

[0026] Step 2. Under continuous stirring, dissolve the above hydroxylated titanium dioxide intermediate in 600g of isopropanol solution, stir for 30min at 80°C and 1000r / min, add 79mL of 10wt% rhododendronic acid isopropanol solution, and mix 30min; add 0.02wt% sulfuric acid accounting for the total mass of azalea in the rhododendron isopropanol solution, and react unde...

Embodiment 2

[0028] A preparation method of rhododendronic acid / titanium dioxide hybrid composite material, comprising the following steps:

[0029] Step 1. Add 350mL of rutile nano-titanium dioxide aqueous solution with a mass concentration of 0.5% into the reaction vessel, stir until uniformly dispersed, then add 4.36mL of 40wt% sodium hydroxide aqueous solution dropwise, and heat up at a rate of 30°C / h after the addition is completed to 80°C, react for 12 hours; after the reaction is completed, cool down to below 60°C, wash and filter with 3 times of water, and obtain the intermediate product of hydroxylated titanium dioxide;

[0030] Step 2. Under continuous stirring, dissolve the above-mentioned hydroxylated titanium dioxide intermediate in 600 g of isopropanol solution, stir for 30 min at 80 ° C and 1000 r / min, add 98.5 mL of 10 wt % rhododendron acid isopropanol solution, Mix for 30 minutes; add sulfuric acid accounting for 0.01wt% of the total mass of azelaic acid in the rhododendr...

Embodiment 3

[0032] A preparation method of rhododendronic acid / titanium dioxide hybrid composite material, comprising the following steps:

[0033] Step 1. Add 150mL of rutile nano-titanium dioxide aqueous solution with a mass concentration of 2% in the reaction vessel, stir until uniformly dispersed, then add 5.0mL of 60wt% sodium hydroxide aqueous solution dropwise, and heat up at a rate of 30°C / h after the addition is completed to 85°C, react for 12 hours; after the reaction is completed, cool down to below 60°C, wash and filter with 3 times of water, and obtain intermediate product of hydroxylated titanium dioxide;

[0034] Step 2. Under continuous stirring, dissolve the above hydroxylated titanium dioxide intermediate in 600g of isopropanol solution, stir for 30min at 80°C and 1000r / min, add 141mL of 10wt% rhododendronic acid isopropanol solution, and mix 30min; add 0.01wt% sulfuric acid accounting for the total mass of azalea in the rhododendron isopropanol solution, and react under...

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Abstract

The invention discloses an azelaic acid / titanium dioxide hybrid composite material and a preparation method thereof. The method comprises the steps that: dropwise adding a caustic alkali aqueous solution into a nanometer titanium dioxide aqueous solution, conducting heating reaction, conducting cooling, washing and filtering after the reaction is completed so as to obtain a hydroxylated titanium dioxide intermediate product; stirring and mixing the hydroxylated titanium dioxide intermediate product with a solvent, performing stirring or ultrasonic dispersing at 75-85 DEG C, then adding an azelaic acid solution, performing mixing, then adding a catalyst, and introducing nitrogen for reflux reaction at 80-100 DEG C; performing sampling and testing the acid value every 30 minutes, and reaching the reaction endpoint when the acid value changes is less than 2 mg KOH / g after continuous two times of sampling; and when the reaction endpoint is reached, performing cooling, cleaning the productby using an impurity removal cleaning agent, performing filtering to obtain a solid powder, and performing drying at low temperature to obtain the azelaic acid / titanium dioxide hybrid composite material. The preparation method disclosed by the invention is simple and feasible, and the prepared hybrid composite material can directionally form a compact protective layer on the surface of skin and has dual effects of resisting bacteria and blocking sun.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations and cosmetics, in particular to a rhododendronic acid / titanium dioxide hybrid composite material and a preparation method thereof. Background technique [0002] Rhododendronic acid, also known as azelaic acid, is a naturally occurring saturated dicarboxylic acid with nine carbon atoms, which is widely used in cosmetics and medicine. Rhododendron acid has good antibacterial properties, can effectively inhibit or kill aerobic and anaerobic bacteria on the skin, reduce free fatty acids and lipids on the skin surface, and is often used to treat acne, acne, rosacea and other skin problems. [0003] Although rhododendron has good efficacy in the fields of medicine and cosmetics, its application is largely limited due to its poor mechanical strength and thermal stability. Therefore, it is particularly important to try to increase the mechanical strength and thermal stability of rhododendron. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/24A61K31/194A61K47/52A61P31/04A61P17/10A61P17/00A61K8/362A61K8/29A61Q17/00A61Q17/04C07F7/28
CPCA61K33/24A61K31/194A61K47/52A61K9/0014A61P31/04A61P17/10A61P17/00A61K8/362A61K8/29A61Q17/005A61Q17/04C07F7/28A61K2800/413A61K2300/00
Inventor 秦一别冯自伟徐守斌
Owner SICHUAN SIPO CHEMICAL CO LTD
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