Preparation method and application of metal surface anticoagulation layer

A metal surface, anti-coagulation technology, applied in the field of metal surface treatment, can solve the problems of difficult anti-coagulation treatment, no evaluation of anti-coagulation effect, etc., and achieve the effect of not easy to fall off and high anti-coagulation performance

Inactive Publication Date: 2020-08-07
北京米道斯医疗器械有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Prior art document 1 (Chu Chenglin et al. Photocatalytic Oxidation Preparation Method of Anticoagulant Titanium Oxide Film on Titanium Alloy Surface [P]. CN101250738B, 2011-09-14.) describes the preparation of titanium oxide on the surface of titanium alloy by photoelectrocatalytic oxidation The film acts as an anticoagulant layer, but the anticoagulant effect was not evaluated
At present, the anticoagulant treatment on the surface of titanium alloy is still a difficult problem

Method used

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  • Preparation method and application of metal surface anticoagulation layer
  • Preparation method and application of metal surface anticoagulation layer
  • Preparation method and application of metal surface anticoagulation layer

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preparation example Construction

[0026] The preparation method of metal surface anticoagulation coating of the present invention comprises the following steps:

[0027] Step 1, preparation of siloxane-based heparin: the reaction between the isocyanate-based siloxane and the heparin occurs between the isocyanate group of the isocyanate-based siloxane and the hydroxyl group in the heparin, in order to ensure that the heparin is completely siloxane Alkylation should make the isocyanate group excess, that is, the molar ratio of isocyanate siloxane to heparin is greater than 1:1; the reaction temperature is controlled at 40°C-60°C; the reaction time is controlled for 4-6 hours. Obtain the heparin of silicon oxygen alkylation, concrete reaction formula is as follows:

[0028]

[0029]

[0030] Wherein: R1, R2, R3 are alkyl groups, and the alkyl groups are preferably -CH3, -CH2CH3

[0031] n is an integer greater than 0, preferably an integer between 2-10

[0032] Step 2, preparation of silanized heparin: pr...

Embodiment 1-3

[0040] Siloxylation of heparin: Dissolve 15g of heparin in 100mL of anhydrous THF, place in a three-necked bottle, stir evenly and pour into dry N 2 , heated to 60°C; 0.5g of 3-isocyanatopropyltriethoxysilane was dissolved in 20mL of anhydrous THF, placed in a dropping funnel, slowly added dropwise into a three-necked bottle, and the dropwise addition was completed in 30 minutes. Continue to maintain the temperature reaction for 4h. Precipitate twice with anhydrous ether and dry in a vacuum oven for 24 hours. A siloxanated heparin is obtained.

[0041] Preparation of siliconized heparin: Add siliconized heparin and purified water into a 500ml beaker according to the weight shown in Table 1, stir evenly at room temperature and fully dissolve, and use the obtained solution after standing for 24 hours.

[0042] Table 1 The formula of the siliconized heparin solution of different concentrations

[0043]

[0044] Coating preparation on the metal surface: ultrasonically clean ...

Embodiment 4

[0049] Siloxylation of heparin: Dissolve 15g of heparin in 100mL of anhydrous THF, place in a three-necked bottle, stir evenly and pour into dry N 2 , heated to 60°C; dissolve 0.65g of octyltriethoxysilane isocyanate in 20mL of anhydrous THF, put it in the dropping funnel, slowly drop it into the three-necked bottle, and drop it in 30 minutes, continue to maintain the temperature Reaction 4h. Precipitate twice with anhydrous ether and dry in a vacuum oven for 24 hours. A siloxanated heparin is obtained.

[0050] Preparation of siliconized heparin: Add 5g of siliconized heparin into a 500ml beaker, then add 95g of purified water, stir evenly and fully dissolve at room temperature, and use the obtained solution after standing for 24 hours.

[0051] Coating preparation on the metal surface: ultrasonically clean the titanium alloy sheet in absolute ethanol for 10 minutes, and dry it in a blast drying oven at 80°C for 2 hours, and then use a plasma gun to clean the surface, and t...

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Abstract

The invention discloses a preparation method and application of a metal surface anticoagulation layer. Heparin which is clinically used as a preferred anticoagulant drug is connected with isocyanate siloxane; an isocyanate group of isocyanate siloxane reacts with hydroxyl of heparin to be combined; then the silanized heparin is obtained after further hydrolysis, the silanized heparin is connectedto the surface of metal in a self-assembly mode in a covalent bond mode, and therefore an anticoagulation coating is formed on the surface of the metal. On one hand, the coating maintains the space structure of the coating and has high anticoagulation performance; meanwhile, by covalent bonding to the surface of metal, heparin molecules are not prone to falling off, and the long-acting anticoagulation effect is achieved. In addition, the invention provides application of the method in a surface anticoagulation coating of the artificial heart titanium alloy blood pump.

Description

technical field [0001] The invention relates to a method for preparing an anticoagulant layer on a metal surface and an application thereof, belonging to the technical field of metal surface treatment. Background technique [0002] Heart disease is the second leading killer of human death. When the human heart partially or completely loses its function due to disease damage and cannot maintain the normal circulation of the whole body, a mechanical device made of artificial materials can be transplanted to temporarily or permanently replace the heart function partially or completely and promote blood circulation. That is, an artificial heart. The magnetic levitation artificial heart is a mechanical device using a magnetic levitation bearing without mechanical contact, which partially or completely replaces the pumping function of the heart, helps the failing heart to complete the blood circulation function, and at the same time reduces the patient's myocardial oxygen consump...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L33/10A61L33/00C08B37/10
CPCA61L33/0011A61L33/0088A61L33/08A61L2420/02C08B37/0075
Inventor 厉蕙蕙陈雪生郑腾
Owner 北京米道斯医疗器械有限公司
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