Composition and preparation for treating novel coronavirus pneumonia and application of composition

A technology of coronavirus and composition, which is applied in the field of composition for the treatment of novel coronavirus pneumonia, can solve the problems of low cure rate and poor clinical curative effect, and achieve the effect of convenient clinical administration, convenient deployment and remarkable clinical effect

Active Publication Date: 2020-07-31
劲牌持正堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no clinically effective drug for the treatment of COVID-19. Western medicine is mainly based on supportive treatment and symptomatic treatment, and supportive treatment is mainly based on maintaining water, electrolyte balance and oxygen therapy. Western medicine should be considered for severe patients

Method used

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  • Composition and preparation for treating novel coronavirus pneumonia and application of composition
  • Composition and preparation for treating novel coronavirus pneumonia and application of composition
  • Composition and preparation for treating novel coronavirus pneumonia and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh 37kg of prescription medicinal materials Bupleurum, 18.5kg of Scutellaria, 18.5kg of Pinellia, 27.8kg of Codonopsis, 18.5kg of Trichosanthes, 18.5kg of Betel nut, 27.8kg of Caoguol, 27.8kg of Magnolia officinalis, 18.5kg of Anemarrhena, and Radix Paeoniae Rubra 18.5kg, licorice 18.5kg, dried tangerine peel 18.5kg, knotweed 18.5kg, add water to extract twice, add 8 times the amount of water for the first time, extract for 120 minutes, and collect volatile oil, add 6 times the amount of water for the second time, extract for 45 minutes, Combine two extracts, filter through 120 mesh, concentrate at 60-80°C to an extract with a relative density of 1.05-1.20 (60-80°C). The dry paste powder spray-dried under the condition of wind temperature 150-170°C, the volatile oil is clathrated with 6 times (ml:g) β-cyclodextrin, and the dry paste powder, volatile oil inclusion complex and a certain amount of auxiliary materials are fully mixed and dried Granulated by law, made int...

Embodiment 2

[0028] The 13 medicinal materials of the prescription were separately extracted one by one according to the digital extraction process, concentrated, and dried to obtain the dry cream powder of each 13 formula granules. Quantify auxiliary material, make 10kg, pack into every bag and dress 18g, take 3 bags every day. See Table 1 below for the detailed ratio of each material added.

[0029] Table 1 Qingfei Dayuan Compound Granules Deployment Equivalent Relation Table

[0030]

[0031]

Embodiment 3

[0033] Get three batches of embodiment 1 and 2 finished formula granules arbitrarily, numbering is sample 1, sample 2, sample 3, carries out thin-layer identification, content determination to the preparation obtained, and identifies the composition content of the preparation product of the present invention gained to meet the requirements, to ensure Effective substances are fully extracted and utilized.

[0034] In this example, the TLC identification and content determination of the sample species Scutellaria baicalensis, Magnolia officinalis and Radix Paeoniae Rubra were carried out respectively.

[0035] Scutellaria baicalensis thin-layer identification method is as follows: Weigh 3g of the powder of this product, grind it finely, add 30ml of methanol, ultrasonically treat it for 30 minutes, filter, and concentrate the filtrate to about 5ml as the test sample. Take another 1 g of Scutellaria baicalensis reference medicinal material, and make the reference medicinal materia...

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Abstract

The present invention relates to a composition for treating novel coronavirus pneumonia. The composition is prepared from the following traditional Chinese medicines in parts by weight: 18-25 parts ofradix bupleuri, 8-15 parts of radix scutellariae, 8-15 parts of rhizoma pinellinae praeparata, 8-15 parts of fructus trichosanthis, 15-20 parts of radix codonopsis pilosulae, 8-15 parts of betel nuts, 15-20 parts of fructus tsaoko, 15-20 parts of officinal magnolia bark, 8-15 parts of rhizoma anemarrhenae, 8-15 parts of radix paeoniae rubra, 8-15 parts of liquorice, 8-15 parts of dried orange peels and 8-15 parts of giant knotweed rhizome. The composition furthest reserves accumulated medicine using experience of traditional Chinese medicine, and is also suitable for modern society, convenient to take and good in taste, widely applied and verified clinically, definite in curative effect and good in treatment effect.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a composition, preparation and application for treating novel coronavirus pneumonia. Background technique [0002] Novel coronavirus pneumonia (COVID-19) is an acute infectious pneumonia caused by a new type of coronavirus, which is characterized by strong infectivity and high prevalence, and the population is generally susceptible. Symptoms of the virus are generally fever, fatigue, dry cough, and gradual dyspnea. In severe cases, acute respiratory distress syndrome, septic shock, metabolic acidosis that is difficult to correct, and coagulation dysfunction. [0003] At present, there is no clinically effective drug for the treatment of COVID-19. Western medicine is mainly based on supportive treatment and symptomatic treatment, and supportive treatment is mainly based on maintaining water, electrolyte balance and oxygen therapy. Western medicine should b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61P31/14A61P11/00
CPCA61K36/233A61K36/344A61K36/428A61K36/484A61K36/539A61K36/575A61K36/65A61K36/704A61K36/71A61K36/752A61K36/8888A61K36/889A61K36/8964A61K36/9064A61K2236/331A61K2236/39A61K2236/51A61P11/00A61P31/14A61K2300/00
Inventor 成焕波胡辉李清安翟红伟龙林孙代华许梦玲黄海华
Owner 劲牌持正堂药业有限公司
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