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Amifostine soluble armored microneedle patch

An amifostine and soluble technology, applied in the field of medical invention, can solve the problem of small dosage of microneedle, and achieve the effects of reducing damage to the body, high drug loading rate, and prolonging the protection period

Inactive Publication Date: 2020-07-31
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dosage of microneedles is generally small

Method used

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  • Amifostine soluble armored microneedle patch
  • Amifostine soluble armored microneedle patch
  • Amifostine soluble armored microneedle patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1. Amifostine soluble armored hyaluronic acid microneedle patch

[0034] Dissolve 100mg of amifostine in 1ml of water, add 50mg of trehalose and 30mg of sodium hyaluronate to dissolve to obtain a drug-containing matrix material solution; drop 0.2g of this solution into 225 conical holes with a depth of 800 μm and a maximum diameter of the hole In a polydimethylsiloxane microneedle mold of 300 μm and a hole spacing of 800 μm, dry it in a vacuum desiccator at room temperature under reduced pressure. in ethanol to obtain a base layer solution; drop the solution into the above-mentioned microneedle mold, and ventilate and dry at room temperature; demold to obtain amifostine soluble hyaluronic acid microneedle patch; prepare 1% 2,4,6- The N-vinylpyrrolidone solution of trimethylbenzoyl-diphenylphosphine oxide is used as the armor layer solution. The needle body part of the amifostine soluble microneedle patch is dipped in the armor layer solution, and after taking...

Embodiment 2

[0037] Embodiment 2. Amifostine soluble armored polyvinylpyrrolidone microneedle patch

[0038] Dissolve 100mg of amifostine in 1ml of water, add 30mg of trehalose and 150mg of polyvinylpyrrolidone K90 to dissolve, and obtain a drug-containing matrix material solution; drop 0.3g of this solution into 225 prismatic holes with a depth of 1000 μm and a maximum diameter of the hole In a polydimethylsiloxane microneedle mold of 300 μm and a hole spacing of 800 μm, dry it in a vacuum desiccator at room temperature under reduced pressure. in ethanol to obtain a base layer solution; drop the solution into the above-mentioned microneedle mold, and ventilate and dry at room temperature; demold to obtain amifostine soluble polyvinylpyrrolidone microneedle patch; prepare 1% 2-hydroxyl-4' The N-vinylpyrrolidone solution of -(2-hydroxyethoxy)-2-methylpropiophenone is used as the armor layer solution, dip the needle part of the amifostine soluble microneedle patch in the armor layer solution...

Embodiment 3

[0039] Embodiment 3. Amifostine soluble armored chitosan microneedle patch

[0040] Dissolve 100mg of amifostine in 1ml of 4% acetic acid aqueous solution, add 30mg of trehalose and 100mg of chitosan to dissolve to obtain a drug-containing matrix material solution; drop 0.2g of this solution into 225 conical holes with a depth of 800 μm , in a polydimethylsiloxane microneedle mold with a maximum pore diameter of 300 μm and a pore spacing of 800 μm, dry in a vacuum desiccator at room temperature under reduced pressure, and wait for the solution to completely enter the microneedle mold holes, and ventilate and dry at room temperature; take 150 mg of polydimethylsiloxane Vinylpyrrolidone K90 was dissolved in ethanol to obtain a base layer solution; the solution was dropped into the above-mentioned microneedle mold, and ventilated and dried at room temperature; demolded to obtain amifostine soluble chitosan microneedle patch; preparation containing 1% of 2-hydroxy -N-vinylpyrrolid...

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Abstract

The invention discloses an amifostine soluble armored microneedle patch. The microneedle patch is composed of an amifostine soluble armored microneedle array and a substrate layer. The amifostine soluble armor microneedle structurally comprises a needle and an armor layer. The armored microneedle can greatly improve the drug dosage, does not influence the mechanical strength, can be smoothly inserted into the skin to implement transdermal drug delivery, achieves a long-time and high-efficiency cell protection effect, and can be used for radiation protection and chemotherapy protection.

Description

technical field [0001] The invention relates to the field of medical inventions, in particular to an amifostine soluble armored microneedle patch and a preparation method thereof. The patch can efficiently deliver amifostine into the body, which can prevent acute radiation sickness and act as a cytoprotective agent. Background technique [0002] Acute radiation disease (ARD) is a systemic disease caused by the body receiving a large dose (>1Gy) of ionizing radiation within a short period of time. According to the characteristics of radiation dose, pathology and clinical process, acute radiation sickness is divided into three types, namely bone marrow type, intestinal type and brain type acute radiation sickness. Bone marrow-type acute radiation sickness is an acute radiation sickness with a typical staged course, with bone marrow hematopoietic tissue damage as the basic lesion and leukopenia, infection, and hemorrhage as the main clinical manifestations. Nuclear acciden...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/32A61K47/36A61K31/661A61P39/00A61M37/00
CPCA61K9/0021A61K47/32A61K47/36A61K31/661A61P39/00A61M37/0015A61M2037/0053A61M2037/0046
Inventor 金义光于翔杜丽娜
Owner ACADEMY OF MILITARY MEDICAL SCI
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