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Antimicrobial treatment method for herpes simplex virus and other infectious diseases

A disease, plant technology, used in the field of drug therapy of herpes virus and other microbial infections, for healing and control of herpes disease, economical and convenient treatment, pain relief

Inactive Publication Date: 2003-07-09
梅里尔·斯奎尔斯
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, AIDS-infected individuals can carry acyclovir-resistant strains of HSV that render acyclovir ineffective in these individuals

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-7

[0049] in vivo test

[0050] In an initial topical application, an in vivo study was undertaken to evaluate the effect of the drug therapies and drugs of the present invention on seven human subjects who tested positive for HSV 1 or 2. Subjects were topically treated with a drug containing an aqueous solution of benzalkonium chloride surfactant (at a ratio of 1:750) and a drug containing the herb Echinacea purpurea in powder form with the phytochemicals listed above. The composition is applied by a two-step procedure: first moisten the affected area or blister with an aqueous solution of benzalkonium chloride surfactant by spraying, dabbing or using a dropper bottle; then by swabbing the powder or sprinkling it by hand Apply the powdered phytochemical lotion to the wetted area over the affected area. An important aspect of this therapy is maintaining complete coverage of the affected area during the onset. Therefore, it can be reapplied as needed to ...

Embodiment 8-13

[0059] Dermatology and Veterinary Tests

[0060] Animal experiments were used to determine the possible allergic skin reactions induced by pharmaceutical compositions (drugs). Six animal subjects were used. These animals included 3 female domestic rabbits (survival age unknown), 2 dogs (1 female, 2 years old, and 1 male, 9 years old), and 1 castrated male cat, 3 years old. In these animal tests, the above-mentioned composition (drug) was administered to the inner side of the outer ear of each animal according to the above-mentioned prescribed method. In all cases, the treated area was kept covered with the compound for 24 hours, while comparisons were made with the time taken by human subjects. Tests on 6 animal subjects showed no signs of skin irritation or allergic reactions.

Embodiment 14

[0062] The above-mentioned pharmaceutical compounds containing viral inhibitors were also tested on papillomavirus-induced warts on the muzzles of two-year-old castrated horses. Papillomavirus warts are difficult to treat. After determination, the diameter of this wart is 25mm. Antimicrobial compounds (drugs) were administered twice daily. This wart is then measured at each application.

[0063] Results: Quite surprisingly, when the drug was applied to the warts, there was a significant reduction in size of the warts by about 3mm / day, and by day 5 the warts had completely regressed. What was observed was: first, the superficial layer of the wart began to degenerate, exposing large erythematous papules. Interestingly, however, instead of exfoliating or desquamating these warts decreased in size, they shrunk closer to the point of attachment to the subject's epidermis and resolved almost intact without scarring.

[0064] ———————————————

[0065] As noted above, in an...

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Abstract

A composition for treating microbial infections comprises antimicrobial isolates from at least a part of the following plants; Echinacea purpurea, E. angustifolia, E. pallidae, E. vegetalis, E. atribactilus, Pimpinella anisum, myroxylon, arctostaphylox, carum, capsicum, Eugenia mytacea, coriandrum, inula, allium, gentiana, juniperus, calendula, origanum, mentha labiate, commiphora, plantago, rosmarinus, ruta, laptisa, artemisa, sage, mentha, parthenium, integrifolium, eucalyptus, asteriacea and their cultivars. Also claimed is a method for treating herpes simplex or other infectious disease, by topical application of a composition containing 2-90 % of a phytochemical concentrate of E. purpurea and E. angustifolia, containing echinacen; echinacen B; echinaceine; echinacoside; caffeic acid ester; echinolone; enzymes; glucuronic acid; inulin; inuloid; pentadecadiene; polyacetylene compounds; polysaccharides; arabinogalactan; rhamnose; tannins; PSI (a 4-O-methylglucoronoarabinoxylan, Mr 35kD) and PS II (an acid rhaminoarabinogalactan, Mr 450 kD), cynarin; 1,5-di-O-caffeoylquinic acid, chicoric acid; 2,3-O-di caffeoyltartaric acid; borneol; bornyl acetate; pentadeca-8(Z) en-zone; germacrene D; caryophyllene; caryophyllene epoxide; anthocyanin, pyrolizidine alkaloid, lipophilic amide; isobutylamide; polyacetylene; anthocyanin; 3-O-B-D glucopyranoside; 3-O-(6-O-malonyl-B-D-glucopyranoside); tussilagine; isotussilagine; isomeric dodeca-isobutylamide; tetraenoic acid; and / or carophylenes; and 0.005 - 0.8 % quat. ammonium salt surfactants comprising alkyl dimethylbenzylammonium chloride, dimethylbenzylammonium chloride, benzalkonium halide, alkylbenzyldimethyl ammonium chloride, dialkyldimethyl ammonium chloride, diisobutylphenoxyethoxyethyl dimethylammonium chloride and o-benzyl-p-chlorophenol; and sterile water in ratio water to phytochemical concentrate and surfactant of 2-100:1. The composition is maintained on the infected area for 1-30 hours, during which period the physical symptoms are substantially resolved.

Description

Background of the invention [0001] The present invention relates to herpes viruses, and more particularly, the present invention relates to drug therapy for herpes virus and other microbial infections. [0002] Herpes simplex virus (HSV), commonly referred to as "herpes virus" or "herpes," is an infectious disease that, as reported by the American Social Health Association (ASHA), has caused a nationwide The number of people infected is 70%-80% of the national population and is increasing by 500,000 people or more every year. There are two common types of herpes: herpes simplex virus 1 (HSV 1) and herpes simplex virus 2 (HSV 2). [0003] The herpes virus usually enters the body through a small break in the epidermal tissue through contact with an infected host and presents as one or more vesicles, usually in clusters, with an incubation period of about 4-10 days. In general, the course of the onset of infection begins with the aura phase; progresses to the development of ves...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A01N33/12A01N65/08A01N65/10A01N65/22A01N65/28A01N65/38A01N65/42A01P3/00A61KA61K9/14A61K31/13A61K31/14A61K31/19A61K31/195A61K31/198A61K36/00A61K36/28A61K36/328A61K36/534A61K36/537A61K36/61A61K36/68A61K36/8962A61K38/27A61K38/28A61K39/385A61P31/12A61P31/22
CPCA61K9/145A61K36/00A61K38/28A61K31/198A61K31/14A61K36/28A61K36/328A61K38/27A61K31/195A61P31/12A61P31/22A61K2300/00
Inventor 梅里尔·斯奎尔斯
Owner 梅里尔·斯奎尔斯
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