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Wet dressing for protecting skin and preparation method of wet dressing

A wet dressing and skin protection technology, applied in the field of materials science, can solve the problems of non-waterproof film, slow drying, easy swelling and elution, etc., and achieve the effects of preventing bacterial infection, low cost, and less keratin damage

Active Publication Date: 2020-06-30
SHANGHAI EAST HOSPITAL EAST HOSPITAL TONGJI UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Cellulose-based materials can also be used to prepare liquid dressings, but traditional cellulose-based materials usually need to use water or alcohol as a solvent, which is easy to grow microorganisms, dries slowly, is not waterproof, and the film is easy to swell and wash off when exposed to water

Method used

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  • Wet dressing for protecting skin and preparation method of wet dressing
  • Wet dressing for protecting skin and preparation method of wet dressing
  • Wet dressing for protecting skin and preparation method of wet dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 100g of pulverized refined cotton (more than 100 mesh) was soaked in 2000g of 32% sodium hydroxide aqueous solution at 26°C for 8 hours; put into an autoclave, evacuated to 0.02MPa, and added 310g of liquid methyl chloride. Raise the temperature to 58°C and keep it for 3 hours; feed nitrogen and add 0.2g of cobalt chloride as a catalyst, continue to raise the temperature to 78°C, keep it for 2.5 hours, distill and recover the excess etherification reagent, wash it with water, and dry it to obtain a Methylcellulose with an average molecular weight of 159kDa and a polydispersity index of 1.05.

[0044] Get above-mentioned methyl cellulose 60.5g and nitrating agent 377ml (the mass percent concentration of 34ml is 65% nitric acid solution, the mass percent concentration of 261ml is 98% sulfuric acid solution and 82ml deionized water) and mix in 1000ml glass kettle; Control reaction temperature 26°C, react for 20 minutes, when the nitrogen content of methyl cellulose reaches...

Embodiment 2

[0048] 100g of pulverized refined cotton (more than 100 mesh) was soaked in 1600g of 42% sodium hydroxide aqueous solution at 22°C for 7 hours; put into an autoclave, evacuated to 0.01MPa, and added 560g of liquid methyl chloride. Raise the temperature to 52°C and keep it for 4 hours; pass in argon and add 0.4g of manganese chloride as a catalyst, continue to raise the temperature to 83°C, keep it for 1.5 hours, distill and recover the excess etherification reagent, wash it with water, and dry it to get Methylcellulose with a number average molecular weight of 202kDa and a polydispersity index of 1.08.

[0049] Get methyl cellulose 58.5g and nitrating agent 580ml (the mass percentage concentration of 54ml is 65% nitric acid solution, the mass percentage concentration of 415ml is 98% sulfuric acid solution and 131ml deionized water) and mix in 1000ml glass kettle; Control reaction temperature is 30°C, react for 22 minutes, when the nitrogen content of methylcellulose reaches 9....

Embodiment 3

[0053] Put 100g of crushed wood pulp (above 100 mesh) at 20°C in 3600g of 40% sodium hydroxide aqueous solution for 9 hours; put it into an autoclave, feed argon, and add 380g of liquid propylene oxide . Raise the temperature to 51°C and keep it for 2 hours; add 0.5g of cobalt chloride as a catalyst, continue to heat up to 78°C, keep it for 2.5 hours, distill and recover the excess etherification reagent, wash with water, and dry to obtain a number average molecular weight of 208kDa, hydroxypropyl cellulose with a polydispersity index of 1.11.

[0054] Get above-mentioned hydroxypropyl cellulose 56.6g and nitrating agent 653.4ml (the mass percent concentration of 95ml is 65% nitric acid solution, the mass percent concentration of 430ml is 98% sulfuric acid solution and 128ml deionized water) and mix in 1000ml glass kettle; The reaction temperature is 30°C, react for 18 minutes, when the nitrogen content of hydroxypropyl cellulose reaches 10.0%, separate the mixed acid, stop t...

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Abstract

The present invention provides a wet dressing for protecting skin. The wet dressing for protecting skin is prepared from halogenated nitrocellulose with a mass percentage concentration of 2-20%, hexamethylsilyl ether with a mass percentage concentration of 4-10%, C6-C9 alkanes with a mass percentage concentration of 2-8% and the balance ester solvent. The nitrocellulose is reacted with organic halides to form halogen-containing nitrocellulose, the halogen-containing nitrocellulose is dissolved in a mixed solvent of polar ester solvents, hexamethyldisilyl ether, and C6-C9 alkanes, the mixture is applied to damaged skin surfaces, the solvent evaporates, and the polymer forms a thin film to cover the skin surface, prevents external bacteria, water or other pollution sources from entering thedamaged skin, avoids infection of the affected area, and promotes wound healing. The wet dressing is non-irritating, has good skin affinity and durability, and can be used for care of large areas andirregular injuries.

Description

technical field [0001] The invention belongs to the field of materials science, and relates to a polymer dressing, in particular to a moist dressing for protecting skin and a preparation method thereof. Background technique [0002] In daily work and life, skin injuries often occur. After the injury, the epidermis is damaged, bleeding occurs, and improper handling may even cause infection. Severe open wounds need to be covered with sterile dressings or clean cloths to prevent the injury from worsening. Common method is to adopt gauze or Band-Aid to bandage or cover the wound. The defect of this method is that air permeability and water resistance are poor, and it is not easy to take care of large area or irregular damage. In the process of hospital diagnosis and treatment, before and after direct contact with pathogenic bacteria and viruses, medical workers need to perform six-step or seven-step hand washing for up to 2 minutes to protect patients and themselves from contam...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08B11/20
CPCA61L26/0023A61L26/0061C08B11/20C08L1/28
Inventor 赵春艳
Owner SHANGHAI EAST HOSPITAL EAST HOSPITAL TONGJI UNIV SCHOOL OF MEDICINE
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