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FePc-loaded metal-organic framework composite nano material, preparation method thereof and application thereof for chemiluminiscence detection

A technology of metal-organic frameworks and composite nanomaterials, which is applied in the direction of chemical reaction of materials, chemiluminescence/bioluminescence, organic compounds/hydrides/coordination complex catalysts, etc., can solve the problem of conjugated rigid macrocycles The structure is insoluble in aqueous solution, limited catalytic activity, and difficult to be practically applied, etc., to achieve the effect of convenient industrial scale production, high catalytic activity, and simple reaction steps

Active Publication Date: 2020-06-23
SHANDONG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the conjugated rigid macrocyclic structures of porphyrin iron and phthalocyanine iron compounds are difficult to dissolve in aqueous solution and tend to exist in the form of aggregates in solution, which greatly limits their catalytic activity and is difficult for practical application.

Method used

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  • FePc-loaded metal-organic framework composite nano material, preparation method thereof and application thereof for chemiluminiscence detection
  • FePc-loaded metal-organic framework composite nano material, preparation method thereof and application thereof for chemiluminiscence detection
  • FePc-loaded metal-organic framework composite nano material, preparation method thereof and application thereof for chemiluminiscence detection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Synthesis of FePc@ZIF-90:

[0054] Heat and stir imidazolyl-2-carboxaldehyde (40.0mg, 0.416mmol) and 20mL DMF at 50℃ until the imidazolyl-2-carboxaldehyde is completely dissolved, then cool to room temperature; add zinc nitrate hexahydrate (31.5mg, 0.106mmol) ) And FePc (4.0mg, 0.0070mmol) were dissolved in 20mL DMF; 172μL trioctylamine was dissolved in 10mL DMF; then imidazolyl-2-formaldehyde solution and Zn(NO 3 ) 2 ·6H 2 The O solution is kept in the refrigerator (4℃) for 20 minutes; under the condition of vigorous stirring, pour the imidazolyl-2-formaldehyde solution into the Zn(NO 3 ) 2 ·6H 2 O solution, then add trioctylamine solution. After stirring for 1 min, the reaction was quenched by adding 20 mL of ethanol. Then, the mixed solution was centrifuged at high speed at 12000 rpm for 20 minutes to obtain a blue solid powder, and a large amount of DMF was used to wash away excess imidazolyl-2-formaldehyde, zinc nitrate, FePc, etc. Finally, they were washed with abso...

Embodiment 2

[0066] Synthesis of FePc@ZIF-90:

[0067] The imidazolyl-2-carboxaldehyde (80.0mg, 0.832mmol) and 40mL DMF were heated and stirred at 50℃ until the imidazolyl-2-carboxaldehyde was completely dissolved, and then cooled to room temperature; the zinc nitrate hexahydrate (89.2mg, 0.300mmol) ) And FePc (8.0mg, 0.014mmol) were dissolved in 40mL DMF; 390μL trioctylamine was dissolved in 20mL DMF; then imidazolyl-2-formaldehyde solution and Zn(NO 3 ) 2 ·6H 2 The O solution is kept in the refrigerator (4℃) for 30 minutes; under the condition of vigorous stirring, pour the imidazolyl-2-formaldehyde solution into the Zn(NO 3 ) 2 ·6H 2 O solution, then add trioctylamine solution. After stirring for 1 min, 40 mL of ethanol was added to quench the reaction. Then, the mixed solution was centrifuged at a high speed of 12000 rpm for 30 minutes to obtain a blue solid powder, and a large amount of DMF was used to wash off excess imidazolyl-2-formaldehyde, zinc nitrate, FePc, etc. Finally, they wer...

Embodiment 3

[0070] The synthesis procedure of FePc@ZIF-90 is the same as in Example 1.

[0071] Synthesis of FePc@ZIF-90-Lum:

[0072] At room temperature, add FePc@ZIF-90 (9mg) and luminol (10mg) into 3mL methanol and stir, add diethylamine (100μL), stir and react for 3h, centrifuge to obtain green powder, wash off with a large amount of DMF The reaction of luminol. Finally, they were washed with absolute ethanol and ether, and the product was dried in a vacuum drying oven at 40°C for 12 hours to obtain a green powder called FePc@ZIF-90-Lum.

[0073] As mentioned in the background art, although iron phthalocyanine (FePc) is used as an artificial peroxidase mimic enzyme to catalyze hydrogen peroxide, the large and rigid conjugated molecular structure of FePc makes FePc hardly soluble in water and easy to aggregate, which greatly reduces The catalytic activity of FePc is reduced, which limits its application as a chemical sensor in the water phase.

[0074] In view of this, the present invention...

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Abstract

The invention relates to a FePc-loaded metal organic framework composite nano material, a preparation method thereof and an application thereof for chemiluminescence detection. The FePc-loaded metal organic framework nano material comprises iron phthalocyanine and a metal organic framework ZIF-90, and the post-synthesized nano material comprises FePc-coated ZIF-90 and a covalently connected luminol functional group. The preparation method comprises the steps of preparing a FePc-loaded metal organic framework nano material by a one-pot method and preparing the covalently connected composite material by a post-synthesis method. The effect of quantitatively detecting the glucose and the hydrogen peroxide is realized. The problem that the iron phthalocyanine is difficult to dissolve in water and is difficult to apply practically is solved.

Description

Technical field [0001] The invention belongs to the technical field of nano material chemical synthesis, and specifically relates to a metal organic frame composite nano material loaded with FePc, a preparation method thereof, and a chemiluminescence detection application. Background technique [0002] Disclosure of the background information is only intended to increase the understanding of the overall background of the present invention, and is not necessarily regarded as an acknowledgement or in any form suggesting that the information constitutes the prior art known to those of ordinary skill in the art. [0003] Diabetes is a public health problem in the world, which is characterized by high blood sugar, high mortality and high morbidity. Excessive glucose concentration in the body's blood easily leads to chronic damage and dysfunction of its tissues, especially eyes, kidneys, heart, blood vessels and nerves. Studies have shown that early diagnosis of diabetes can delay and p...

Claims

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Application Information

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IPC IPC(8): B01J31/22G01N21/76
CPCB01J31/003B01J31/183B01J31/1691G01N21/76B01J2531/26B01J2531/842B01J2540/40
Inventor 董育斌吕凡宏阚京兰田冰
Owner SHANDONG NORMAL UNIV
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