Rhus chinensis total phenolic acid micropellets and preparation method thereof
A technology of total phenolic acid pellets and chrysanthemum, which is applied in the direction of pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. Difficult pilling, strong wetness and other problems, to achieve the effect of large-scale industrial production, good pilling performance and good reproducibility
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0043] Embodiment 1, the preparation of total phenolic acid of the present invention
[0044] Take an appropriate amount of the coarse powder of the medicinal material, add 20 times the amount of 70% ethanol (that is, add 20 mL of 70% ethanol to 1 g of the coarse powder of the medicinal material), soak for 30 minutes, reflux extraction for 90 minutes, extract twice, filter, and combine the filtrates to obtain the Crude wood extract. The ethanol was recovered by a rotary evaporator, and evaporated until there was no alcohol smell, to obtain the lycopodium concentrate, which was centrifuged for 10 minutes (5000r / min), and the supernatant was taken, and purified by macroporous resin. Select SP825L resin, the ratio of diameter to height is 1:5, the maximum sample loading is 0.35g of crude drug per gram of dry resin, and the adsorption flow rate is 1BV / h; the impurity removal solvent is 0.1% glacial acetic acid, the dosage is 4BV, and the impurity removal solvent flow rate The enric...
Embodiment 2
[0045] Example 2, preparation and characterization of the present invention's total phenolic acid pellets
[0046] 1. The preparation of the total phenolic acid pellets of S. japonicus of the present invention
[0047] The present invention adopts extruding and spheronizing method to prepare the total phenolic acid pellets of S. chinensis, and the raw materials of the total phenolic acids of S. 10.5g, silicon dioxide 6.75g. Among them, microcrystalline cellulose and lactose are used as diluents; silicon dioxide is used as an anti-adhesive agent; the drug loading of the total phenolic acid pellets prepared by S. chinensis is 28.7%. Drug loading=mass of total phenolic acids of S. chinensis / (mass of total phenolic acids of S. chinensis+total mass of other raw materials)×100%, wherein other raw materials are microcrystalline cellulose, lactose and silicon dioxide.
[0048] Preparation process parameters: the extrusion speed is 43r / min, the spheronization speed is 1800r / min, and ...
PUM
Property | Measurement | Unit |
---|---|---|
Particle size | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com