An ion mobility spectrometer-time-of-flight mass spectrometer

Abstract

The invention relates to a mass spectrometry instrument, in particular to an ionic migration spectrometry-flight time mass spectrometer, and the mass spectrometer comprises an ionic migration spectrometry cavity, a mass spectrometry transmission area cavity, a mass analyzer cavity and a data acquisition card; an ionization source, an ion gate and an ion migration region electrode are sequentiallyarranged in the ionic migration spectrometry cavity from top to bottom; a repulsion polar plate, a flight time mass analyzer and a micro-channel plate detector are arranged in the mass analyzer cavity; pulse voltages Ugate, Upulse and Ucard are respectively applied to acquisition trigger terminals of the ion gate, the repulsion polar plate and the acquisition card; and the pulse voltage Upse and the pulse voltage Ucard are synchronized based on the rising edge or falling edge moment of the pulse signal of the pulse voltage Ugate. The ionic migration spectrometry-flight time mass spectrometer can effectively improve the utilization efficiency of ions, the two-dimensional analysis speed of ionic migration spectrometry-mass spectrometry and the detection sensitivity by synchronizing and modulating the pulse time sequences of the ion gate, the repulsion polar plate and the acquisition card.

Description

technical field [0001] The invention relates to a mass spectrometry instrument, in particular to a time-of-flight mass spectrometry instrument, in particular to an ion mobility spectrometry-time-of-flight mass spectrometry instrument. Background technique [0002] Time-of-Flight Mass Spectrometry (TOFMS) is a method that calculates the mass-to-charge ratio m / z of ions by measuring the flight time of ions in the electric field in a vacuum environment to the detector to obtain the molecular mass and realize the material Qualitative analysis mass spectrometry technology has high resolution and sensitivity, wide mass range, fast response speed in microseconds and the ability to measure the whole spectrum at the same time, so it is widely used in various fields such as environment, materials, chemical industry, and biology. However, for isomers with the same elemental composition but different structures, because their molecular weights are exactly the same, it is difficult to ac...

AI Technical Summary

Problems solved by technology

The introduction of the second-level ion gate needs to divide the ions in one IMS cycle into small ion slices according to the order of migration time. Each IMS cycle can only allow a small portion of ion slices to enter the TOFMS for detection, and the rest of the ions will be opened. It is lost on the ion gate, which will greatly affect the utilization efficiency of ions. It takes a long time to accumulate and complete a sample test to obtain the two-dimensional spectrum data of migration spectrum-mass-to-charge ratio

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