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Anti-inflammatory compound and application thereof

Technology of a compound and use, applied in the field of anti-inflammatory compounds

Pending Publication Date: 2020-06-02
福州百草堂医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is: how to synthesize a class of compounds to have the effects of skin anti-pollution, inhibition of tyrosinase, repair of stratum corneum, regulation of skin immune function, and treatment of skin eczema and psoriasis, making it Can be used to prepare cosmetic reagents or pharmaceutical reagents

Method used

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  • Anti-inflammatory compound and application thereof
  • Anti-inflammatory compound and application thereof
  • Anti-inflammatory compound and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Preparation method of anti-inflammatory compound:

[0043] Step 1: Isopropylation

[0044]Add 1kg of water to the reaction kettle, add 7kg of concentrated sulfuric acid dropwise to the water, after the dropwise addition is completed, turn on the heating of the reaction kettle and set it at 80°C, after the temperature of the liquid in the kettle drops to 80°C, add 1kg of 3,5-dimethoxy Methyl benzoate, then add 310g of isopropanol dropwise, react at 80°C for 1h after the dropwise addition, cool down to room temperature, add 5kg of water dropwise to the reaction solution, control the temperature during the dropwise addition to not exceed 90°C, and complete the dropwise addition Cool down to room temperature, filter, wash the filter cake with appropriate amount of water, press filter until there is no liquid dripping, and dry at 85°C. The product is recrystallized with xylene to obtain 812g of white needle-like solid product with a yield of 71%.

[0045]

[0046] Step 2...

Embodiment 2

[0068] The application of the anti-inflammatory compound provided in Example 1 of the present application in cosmetics, Example 1 is applied in cream, as shown in formula table 1:

[0069] Table 1

[0070]

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Abstract

The invention relates to the technical field of chemical cosmetics or medicines, and concretely relates to an anti-inflammatory compound and an application thereof. By preparing a series of compoundswith an anti-inflammatory function, the obtained anti-inflammatory compound can be used for preparing cosmetic reagents or pharmaceutical reagents, and the cosmetic reagents and the pharmaceutical reagents are not specifically limited, for example, the cosmetics can be a smoothing toner, a nutritional toner, a massage cream, a nutritional cream, a mask, an emollient, a gel, and gel or shower gel shampoo and other washing type cosmetics, and can also be a pharmaceutical preparation product similar to lotion and cream, ointment, cream, plaster or spray and the like. The anti-inflammatory compound also can be used by sensitive skins, and also can be added into infant and child cosmetics to reduce irritation.

Description

technical field [0001] The invention relates to the technical fields of cosmetics and medicines, in particular to a class of anti-inflammatory compounds and uses thereof. Background technique [0002] Since the beginning of the 21st century, with the influence of population growth, urbanization, industrialization and the increase of automobiles, air pollution has become serious, and air pollution in environmental pollution has a harmful effect on the skin. Studies have shown that air pollutants mainly include dust containing heavy metals and microorganisms, fine particulate matter (such as PM 2.5), NO, NO2, carbon monoxide, sulfur dioxide, ozone O3, polycyclic aromatic hydrocarbons (PAHs) and smog formed by water vapor. These air pollutants are not only deadly to the lungs and heart, but also to the skin. Exposure of the skin to air pollutants predisposes the skin to aging and inflammation or allergic skin conditions. Researchers studied the association of fine particulate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C39/15C07C39/21C07C37/055C07C37/00A61K31/05A61K8/34A61P17/00A61P17/06A61P25/00A61P29/00A61P37/02A61P37/08A61Q17/00A61Q19/00A61Q19/02A61Q19/10
CPCC07C39/15C07C39/21A61P17/06A61P17/00A61P25/00A61P29/00A61P37/02A61P37/08A61K8/347A61Q17/00A61Q19/005A61Q19/02A61Q19/10
Inventor 滕景斌吴峰肖永堂
Owner 福州百草堂医药科技有限公司
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