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Application of sanguinarine in inhibiting growth of streptococcus pneumonia

A technology for Streptococcus pneumoniae and sanguinarine, which is used in antibacterial drugs, medical preparations containing active ingredients, respiratory diseases, etc. Infection problem, wide application value, effect of reducing case fatality rate

Pending Publication Date: 2020-05-19
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent CN110772518A discloses the application of sanguinarine in inhibiting the growth of Staphylococcus ludunensis, but there is currently no literature report on the growth of highly pathogenic Streptococcus pneumoniae inhibited by sanguinarine

Method used

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  • Application of sanguinarine in inhibiting growth of streptococcus pneumonia
  • Application of sanguinarine in inhibiting growth of streptococcus pneumonia
  • Application of sanguinarine in inhibiting growth of streptococcus pneumonia

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Embodiment Construction

[0013] The present invention will be described in further detail below in conjunction with the examples. The embodiments are only used to explain the present invention, not to limit the protection scope of the present invention.

[0014] 1. Drug susceptibility test of Streptococcus pneumoniae

[0015] The present invention uses multiple strains of human Streptococcus pneumoniae (strain samples taken from Beijing Haidian Hospital) as starting strains, and selects levofloxacin, ofloxacin, moxifloxacin, erythromycin, chloramphenicol, and telithromycin 10 commonly used antibiotics were tested, including tricycline, vancomycin, linezolid, and co-trimoxazole.

[0016] The pure colonies picked and cultured for 18-24 hours were evenly dissolved in 2-5 mL sterile saline, and the turbidity was adjusted to be equal to that of a 0.5 McFarland turbidimetric tube. The antibiotics, bacterial liquid and TSB liquid medium were added to the 96-well culture plate by the double dilution method ...

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Abstract

The invention discloses an application of sanguinarine in inhibiting the growth of streptococcus pneumonia, according to the fact that the sanguinarine has a good in-vitro killing effect on streptococcus pneumonia, the sanguinarine can inhibit the growth of streptococcus pneumonia, the minimum bactericidal concentration is 31.2 mu g / mL, and the minimum inhibitory concentration is 15.6 mu g / mL. Thesanguinarine provided by the invention has an inhibition effect on pneumonia streptococcus, and has a wide application value in the fields of medicines and the like.

Description

technical field [0001] The invention relates to the fields of medicine and food safety, in particular to the application of sanguinarine in inhibiting the growth of Streptococcus pneumoniae. Background technique [0002] Streptococcus pneumoniae (Streptococcus pneumoniae) is a Gram-positive bacterium of Streptococcus family Streptococcus, which is the main pathogenic bacteria of community-acquired pneumonia in children. The main symptoms include pneumonia, meningitis, otitis media, etc. Under normal circumstances, Streptococcus pneumoniae is often in a carrier state, mainly attaching to the epithelial cells of the nasopharynx and oral cavity of the human body. However, once the body's immune function declines, or it is subjected to physiological violations, mechanical barrier damage, etc., it will provide a source for the reproduction of Streptococcus pneumoniae. More opportunities will spread to the nasal cavity, bronchi, middle ear, lungs, etc., leading to inflammatory re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4741A61P31/04A61P11/00
CPCA61K31/4741A61P11/00A61P31/04
Inventor 钱卫东刘淼崔雅欣付玉婷张家宁杨敏孙照欢
Owner SHAANXI UNIV OF SCI & TECH
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