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Composition for controlling weight by modulating levels of peptides involved in fullness and/or appetite

A composition, satiety technology, applied in the field of nutritional supplements, can solve the problem of death, not scientifically proven, etc.

Inactive Publication Date: 2020-05-12
MONTELOEDER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Bariatric surgery has the same disadvantages as any surgical intervention, and there have even been cases of death during the procedure
Disadvantages of drug therapy are also known, known as "side effects", which can occur with more or less severity
In addition, there are many dietary supplements or nutritional products whose weight loss, fat burning or appetite reducing effects are widely advocated, but they are not scientifically proven, and they are questionable, or in the best case, are Results of placebo or autosuggestion effects

Method used

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  • Composition for controlling weight by modulating levels of peptides involved in fullness and/or appetite
  • Composition for controlling weight by modulating levels of peptides involved in fullness and/or appetite
  • Composition for controlling weight by modulating levels of peptides involved in fullness and/or appetite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Determined ratio of lemon verbena and roselle extracts

[0068] 3T3-L1 preadipocytes were cultured in a 96-well plate with complete medium (DMEM containing 1 g / L low glucose) and sodium pyruvate, which was rich in glutamine, and treated with 10% bovine serum and antibiotics ( 100 μg / mL streptomycin and 100 U / mL penicillin) supplemented.

[0069] Adipogenic differentiation was induced by adding adipogenic agents (0.5 mM IBMX, 1 μM DEX and 1 μM insulin) to the medium during two days. The medium was replaced with fresh medium every 48 hours.

[0070] Phenotypic changes in adipocytes were observed microscopically. In all experiments, more than 90% of the cells were mature adipocytes after 8-10 days in culture. To induce cellular hypertrophy, adipocytes were exposed to high glucose medium (25 mM).

[0071] Use a laminar flow hood for cell culture and with 5% CO 2 Perform cell culture under sterile conditions in a 37 °C incubator with a humid atmosphere.

[0072] The ef...

Embodiment 2

[0078] Evaluation of decreased body fat, hyperlipidemia, hyperglycemia and lipogenesis in obese mice treated with a composition containing lemon verbena and roselle extracts.

[0079] In vivo experiments were performed with normal mice fed a high fat diet (HFD) during 8 weeks. Analyze whole blood cholesterol as well as HDL cholesterol (good cholesterol or high-density lipoprotein) and LDL cholesterol (bad cholesterol or low-density lipoprotein).

[0080] The result is as Figure 4 Shown, wherein, respectively, C57bl / 6-Nr corresponds to normal diet mice, HFD-CTL corresponds to high-fat diet mice (HFD), HFD-LV corresponds to taking about 30% by weight of phenylpropanoid lemon verbena extract of high-fat diet mice, HFD-HS corresponds to high-fat diet mice taking about 10% by weight of anthocyanin Roselle High-fat diet mice with a composition of herbaceous and roselle extracts.

[0081] The results showed that the mice administered the two extract compositions had lower total c...

Embodiment 3

[0102] Reduce appetite and / or increase satiety due to changes in the levels of peptides secreted by the digestive tract and adipose tissue due to ingestion of a composition comprising lemon verbena extract with 30% by weight phenylpropanoid and with 10% by weight % anthocyanins of roselle extract in a weight ratio of 65:35.

[0103] Choose age between 35-75 years old and BMI between 25-35kg / m 2 among 54 women. The study was an 8-week, randomized, double-blind, placebo-controlled assay conducted at the Miguel Hernandez University of Elche, Spain. After recruitment, volunteers were randomly assigned to placebo-controlled L2 group (n=26) or experimental L1 group (n=28).

[0104] L1 group members (average age 51 years) received a daily dose of 500 mg of a composition containing lemon verbena and roselle extracts.

[0105] Members of the L2 group (mean age 51 years) received a daily dose of 500 mg microcrystalline cellulose.

[0106] The placebo and satiety effect composition cap...

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Abstract

The present invention discloses compositions comprising an extract containing at least 5% anthocyanines by weight and an extract containing at least 15% phenylpropanoids by weight which are especiallyindicated for use during periods of weight loss as same reduce appetite and increase fullness by modifying the levels of hormones secreted in the digestive tract. Said compositions affect lipid metabolism in adipose tissue cells by activating AMPK and oxidation and lipid-removal processes in a parallel or complementary manner. Said composition is obtained by hydroalcoholic extraction of roselle flower and lemon verbena (Aloysia citriodora) leaf using, in the case of the latter, alcohol (ethanol, methanol, propanol, isopropanol or butanol) concentrations of more than 70% and up to 100% by volume.

Description

technical field [0001] The present invention is constructed within the technical fields of nutritional supplements, functional foods, pharmaceutical compositions and animal use; in order to control body weight and appetite, especially for overweight or obese humans. In particular, the present invention relates to compositions comprising two polyphenolic plant extracts. Background technique [0002] Obesity has been demonstrated by the World Health Organization (WHO) to be a global epidemic associated with several metabolic imbalances that cause increased adipose tissue mass, endothelial dysfunction, dyslipidemia, hypertension, atherosclerosis, and insulin resistance. Taken together, these imbalances constitute a complex pathology known worldwide as the metabolic syndrome. [0003] Obesity is defined as a condition of excess fat accumulation in adipose tissue, which implies health risks and predisposes to insulin resistance, hypertension and dyslipidemia. It is generally ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61K36/185A23L33/105A61P3/00A61P3/04
CPCA23L33/105A61K36/185A61K36/85A61P3/00A61P33/04A61K2236/333A61K2300/00A61K31/352A61P3/04A23V2002/00A23V2200/332A23L29/035
Inventor M·赫兰兹 洛佩兹E·罗奇 克拉多V·麦可 莫利纳J·R·琼斯 巴贝拉N·卡塔拉 塞努达
Owner MONTELOEDER
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