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Application of Alpinia japonica extract and preparation method thereof

A kind of ginger extract and the technology of the extract are applied in the application and preparation field of the ginger extract to achieve the effect of kidney function and anti-gout

Inactive Publication Date: 2018-01-05
武汉翼博济生生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0021] However, there are no reports in the literature that Alpinia genus plants have the pharmacological effects of lowering uric acid and anti-gout

Method used

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  • Application of Alpinia japonica extract and preparation method thereof
  • Application of Alpinia japonica extract and preparation method thereof
  • Application of Alpinia japonica extract and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1 Preparation of Alpine Alcohol Extract

[0055] Mountain ginger was purchased from the Bozhou medicinal material market and was identified as the rhizome of Alpinia galanga (Linnaeus) Willdenow, a perennial herb in the ginger family. After the medicinal materials are dried, they are crushed by a pulverizer, passed through a 20-mesh sieve, and extracted twice with a 50% volume percent ethanol aqueous solution. The quality of the ethanol solution used is 12 times and 10 times that of the mountain ginger medicinal material. The reflux time is 2h and 1.5h once, and the two extracts are filtered and combined to recover ethanol to obtain the alcohol extract of mountain ginger.

[0056] (The "X% ethanol" mentioned in the following refers to an aqueous ethanol solution with a volume percentage concentration of X%)

Embodiment 2

[0057] Example 2 Preparation of Alpine total phenolic acid

[0058] The alcohol extract of Alpine in Example 1 was successively enriched and refined with HPD100 macroporous adsorption resin to obtain total phenolic acid of Alpine;

[0059] The purification process of HPD100 macroporous adsorption resin is as follows: add alcohol extract of mountain ginger and pure water to adjust the concentration to 0.01g medicinal material / mL, at the same time adjust the pH of the liquid to 4 with 1% sulfuric acid aqueous solution, and adsorb on HPD100 resin column, first use 3 It is eluted with two times the column volume of pure water, then with 2 times the column volume of 20% ethanol, and then with 3 times the column volume of 60% ethanol. Collect the 60% ethanol eluate and recover it under reduced pressure until it has no alcohol taste to obtain the HPD100 resin eluate, which is spray-dried to obtain the total phenolic acid of alpinia;

Embodiment 3

[0060] Example 3 Preparation of mountain ginger total flavonoids and total phenylpropanoids

[0061] The HPD100 resin eluent in Example 2 was adjusted to a concentration of 0.02g medicinal materials / mL, and applied to a 100 mesh polyamide column, first eluted with 2 times the column volume of water, and then respectively used 3 times the column volume of 10% ethanol , 5 column volume of 30% ethanol and 4 column volume of 70% ethanol for elution. Collect 30% ethanol eluate, recover at least the volume under reduced pressure, then freeze-dry to obtain the total phenylpropanoid part of mountain ginger; collect 70% ethanol eluate, recover at least volume under reduced pressure, and freeze-dry , Get the total flavonoids of mountain ginger.

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Abstract

The invention discloses an application of Alpinia japonica extract. The Alpinia japonica extract contains total phenylpropanoids of Alpinia japonica and is used for preparation of medicines for reducing uric acid and resisting gout. A research result shows that total phenylpropanoids of Alpinia japonica, a mixture of total phenylpropanoids of Alpinia japonica and total flavonoids of Alpinia japonica, Alpinia japonica alcohol extract and extract of total phenolic acids of Alpinia japonica have very extreme uric acid reduction effects better than those of the known uric acid reduction plant extract and better than that of a positive drug allopurinol, have good effects of protecting renal functions and resisting gout, are safe and effective and have a development and application prospect.

Description

Technical field [0001] The invention belongs to the field of Chinese medicine extracts, and specifically relates to an application of mountain ginger extracts and a preparation method thereof. Background technique [0002] The most representative feature of hyperuricemia is that the uric acid in the circulating blood is higher than the normal level (greater than 7.0 mg / dl) and maintained for a long time. The dynamic relationship between the metabolism of purine to synthesize uric acid and the rate of uric acid excretion from the body determines the amount of uric acid in the circulating blood. The accumulation of uric acid in the circulating blood of the human body can generally be attributed to the following reasons: ①Excessive intake of purines outside the body, that is, the human body eats a lot of foods rich in purines; ②The metabolism of purines in the body is increased, which is large. Partly because of the abnormality of related enzymes in a series of biochemical effects ...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61P19/06A61K31/222A61K31/11
Inventor 不公告发明人
Owner 武汉翼博济生生物科技有限公司
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