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Injectable glucose response self-healing hydrogel, and preparation method and application thereof

A glucose-responsive, hydrogel technology, applied in pharmaceutical formulations, medical formulations with non-active ingredients, and medical formulations containing active ingredients, etc. problem, to achieve the effect of good biocompatibility, reduced risk of leakage, and high sensitivity

Pending Publication Date: 2020-05-12
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the gelation of the hydrogel needs to be left overnight, which takes a long time, and the grid density of the gel cannot be adjusted, and the drug has the risk of leakage under normal blood sugar conditions.

Method used

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  • Injectable glucose response self-healing hydrogel, and preparation method and application thereof
  • Injectable glucose response self-healing hydrogel, and preparation method and application thereof
  • Injectable glucose response self-healing hydrogel, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0056] Preparation of phenylboronic acid-based modified polymer (FPBA-PEG) and polyvinyl alcohol 0588 (PVA) glucose-responsive hydrogel based on 4-carboxy-3-fluoro-phenylboronic acid modified 4-arm-polyethylene glycol-amino preparation

[0057] (1) Synthesis of FPBA-PEG

[0058] 1 g (0.2 mmol) of 4-arm-polyethylene glycol-amino was added to a 50 ml round bottom flask and dissolved in dichloromethane, followed by 0.441 g (2.4 mmol) of 4-carboxy-3-fluoro-phenylboronic acid (FPBA), 0.367g (2.4mmol) 1-hydroxybenzotriazole monohydrate (HOBt), 0.910g (2.4mmol) benzotriazole-N,N,N',N'-tetramethylurea Hexafluorophosphate (HBTU), 0.67 mL of triethylamine, followed by N,N-dimethylformamide (DMF) was added to dissolve HOBt, HBTU, and FPBA. After reacting at room temperature for 24 hours, dichloromethane was removed by rotary evaporation, and the reactant was transferred to a dialysis bag with a molecular weight cut-off of 2 kDa, and dialyzed in deionized water for 24 hours, changing th...

Embodiment 2

[0062] Preparation of In Situ Formed Hydrogels by Dual Syringes

[0063] Mix the prepared 0.1 ml FPBA-PEG solution (10% w / v, 15% w / v, 20% w / v) with 0.1 ml PVA (10% w / v) solution via a double syringe to form in situ molding gel. figure 2 Photographs for the preparation of in situ formed hydrogels using a dual syringe. Utilize scanning electron microscope to analyze the hydrogel that obtains in embodiment two, obtain its scanning electron micrograph as image 3 shown.

[0064] From image 3 It can be observed that as the solid content of the hydrogel increases, the number of phenylboronic esters formed in the system increases, and the cross-linking density of the gel increases, showing that the grid is tighter, and the grid density of Gel-15 is the smallest. Gel-10 has the highest mesh density, and Gel-12.5 mesh density is in between.

Embodiment 3

[0066] Self-healing properties of FPBA-PEG / PVA hydrogel

[0067] Taking Gel-15 as an example to study the self-healing property of the gel, since the gel is colorless and transparent, in order to feel the self-healing of the hydrogel more intuitively, crystal violet, rhodamine B and FITC were added to the gel -insulin, and then bond the three gels together, and the hydrogel will self-heal into a complete whole within 60s. Photos of hydrogel self-healing such as Figure 4 shown.

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Abstract

The invention relates to an injectable glucose response self-healing hydrogel, and a preparation method and an application thereof, and belongs to the technical field of biomedical materials. The injectable glucose response self-healing hydrogel comprises an active component phenylboronic acid group modified polymer, polyvinyl alcohol and water, and the chemical structural formula of the phenylboronic acid group modified polymer is shown in the specification. The hydrogel is constructed through a phenylboronic acid ester dynamic bond, the hydrogel has glucose response, and dynamic gel has repairability and injectability at the same time, so the hydrogel can be implanted into a focus part in an injection mode, and pain and complexity of surgical implantation are avoided.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials. More specifically, it relates to an injectable glucose-responsive self-healing hydrogel, its preparation method and its application as a drug-loading material. Background technique [0002] According to the latest research, about 400 million people worldwide suffer from diabetes. Diabetes is a metabolic disease characterized by the body's inability to maintain normal blood sugar levels. The usual treatment for most people with diabetes is daily subcutaneous insulin injections. Although daily insulin injections can lower blood sugar levels in patients, frequent subcutaneous injections have brought great pain to patients. For example, pain during injection, hypoglycemic effect in a short period of time after injection, and may cause syncope and shock in severe cases. [0003] In order to avoid diabetic complications caused by frequent injections and unstable blood sugar levels, it ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L71/02C08L29/04C08G65/337A61K38/28A61K9/06A61K47/24A61K47/32A61P3/10
CPCC08J3/075C08G65/337A61K38/28A61K9/06A61K9/0019A61K47/24A61K47/32A61P3/10C08J2371/02C08J2429/04C08J2329/04
Inventor 蔡挺刘波彭亚运
Owner CHINA PHARM UNIV
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