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Preparation method of nanocapsules carrying fat-soluble active substances

An active, fat-soluble technology, used in organic active ingredients, preparations for skin care, medical preparations with non-active ingredients, etc., can solve the problems of affecting the use effect, unstable nanocapsule ions, etc. Beneficial for transdermal absorption and good occlusive effect

Pending Publication Date: 2020-05-08
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, lipid nanocapsules have been used to embed various fat-soluble active substances, such as CoQ10, vitamins, carotenoids, etc., but there is a problem that nanocapsules are unstable to ions, which affects the use effect

Method used

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  • Preparation method of nanocapsules carrying fat-soluble active substances
  • Preparation method of nanocapsules carrying fat-soluble active substances
  • Preparation method of nanocapsules carrying fat-soluble active substances

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Isopropyl myristate: 3g

[0029] Cetyl Palmitate: 7g

[0030] Coenzyme Q10: 2.5g

[0031] PC60: 3g

[0032] Glycerin: 20g

[0033] Water: balance, a total of 100g

[0034] Mix PC60, hexaglyceryl monolaurate, glycerin and water, and magnetically stir in a water bath at 80°C until the water phase is clear and transparent; mix caprylic capric triglyceride, cetyl palmitate, and fat-soluble active substances , heat and dissolve in a water bath at 80°C until the oil phase is clear and transparent; add the water phase to the oil phase, disperse at 10,000rpm at a high speed, disperse for 3min, then use a high-pressure homogenizer at 60MPa, circulate 6 times, and cool at room temperature to prepare the carrier Nanocapsules of curcumin.

[0035] The obtained nanocapsules are milky, the loading capacity of coenzyme Q10 is 2.5%, and the encapsulation efficiency is about 99.6%. The particle size measured by Zeta potential and nano particle size analyzer is 150nm, and the partic...

Embodiment 2

[0037] Caprylic capric triglyceride:: 5g

[0038] Coenzyme Q10: 5g

[0039] PC60: 2g

[0040] Ten polyglyceryl monolaurate: 3g

[0041] Glycerin: 70g

[0042] Water: balance, a total of 100g

[0043] Mix PC80, decaglycerol monomyristate, glycerin and water, and magnetically stir in a water bath at 60°C until the water phase is clear and transparent; mix caprylic capric triglyceride and coenzyme Q10, and heat in a water bath at 60°C Dissolve until the oil phase is clear and transparent; add the water phase to the oil phase, disperse at 15,000rpm at a high speed, disperse for 2 minutes, then use a high-pressure homogenizer at 80MPa, cycle 3 times, and cool at room temperature to prepare nanocapsules carrying coenzyme Q10.

[0044] The obtained nanocapsules are transparent liquid, the loading capacity of coenzyme Q10 is 5%, and the encapsulation efficiency is about 99.2%. The particle size is 59nm measured by Zeta potential and nano particle size analyzer. After 90 days at room...

Embodiment 3

[0046] Caprylic Capric Triglyceride: 2.5g

[0047] Glyceryl Cetyl Palmitate: 2.5g

[0048] Coenzyme Q10: 5g

[0049] PC60: 2g

[0050] Ten polyglyceryl monolaurate: 3g

[0051] Glycerin: 70g

[0052] Water: balance, a total of 100g

[0053] Mix PC80, decaglycerol monomyristate, glycerin and water, and magnetically stir in a water bath at 60°C until the water phase is clear and transparent; mix caprylic capric triglyceride and coenzyme Q10, and heat in a water bath at 60°C Dissolve until the oil phase is clear and transparent; add the water phase to the oil phase, disperse at 15,000rpm at a high speed, disperse for 2 minutes, then use a high-pressure homogenizer at 80MPa, cycle 3 times, and cool at room temperature to prepare nanocapsules carrying coenzyme Q10.

[0054] The obtained nanocapsule is a transparent liquid, the coenzyme Q10 load is 5%, and the encapsulation efficiency is about 99.5%. The differential scanning calorimetry (DSC) results show that the solid lipid ...

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Abstract

The invention discloses a preparation method of nanocapsules carrying fat-soluble active substances. The nanocapsules comprise liquid lipids, solid lipids, fat-soluble active substances, phospholipids, nonionic emulsifiers, polyols and water. In percentage by weight, the nanocapsules comprise 0.1-20% of liquid lipids, 0-20% of solid lipids, 0.1-15% of fat-soluble active substances, 0.1-10% of phospholipids, 0.1-5% of nonionic emulsifiers, 40-90% of polyols and the balance of water. The nanocapsules are made by dispersing the raw materials at high pressure and conducting homogenization. The solid lipids in the nanocapsules have high crystallinity, and a dense film can be formed on the skin surface, so that the nanocapsules have better closing effect, reduce the evaporation of moisture on the skin surface, improve hydration level of the skin surface, and loosen a stratum corneum structure, thereby facilitating transdermal absorption of the active substances.

Description

technical field [0001] The invention belongs to the technical field of micro-nano carriers, and in particular relates to a preparation method of nanocapsules carrying fat-soluble active substances. Background technique [0002] Micro-nano carrier technology is a technology to protect and deliver active ingredients with low solubility, poor stability, and low availability. Using materials with good biocompatibility to prepare micro-nano carriers, embedding active substances in the interior of micro-nano carriers or adsorbing them on the surface through adsorption, dissolution, etc., is an effective technology for protecting and transporting active ingredients . Compared with chemical modification technology, micro-nano carrier technology basically does not affect the functional properties of active ingredients, and the operation method is relatively simple. [0003] Commonly used micro-nano carriers mainly include nanoemulsions, nanostructured lipid carriers, lipid nanocaps...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/67A61K8/34A61K8/68A61K8/35A61K8/37A61K8/11A61Q19/00A61K9/50A61K47/10A61K47/14A61K31/355A61K31/122A61K31/12A61K31/164
CPCA61K8/11A61K8/345A61K8/35A61K8/355A61K8/37A61K8/375A61K8/678A61K8/68A61K9/5015A61K31/12A61K31/122A61K31/164A61K31/355A61K2800/10A61Q19/00
Inventor 梁蓉杨成谢桂杰
Owner JIANGNAN UNIV
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