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Light flash thermal desorption-delayed purging sample injection method for drug mixture detection

A mixture and thermal desorption technology, used in analytical materials, measuring devices, sample introduction/extraction, etc., to achieve the effect of improving ionization efficiency, fast heating speed, and improving detection sensitivity

Active Publication Date: 2020-05-05
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The object of the present invention is to provide a kind of fast simultaneous detection method that solves volatile and difficult volatile drug mixture

Method used

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  • Light flash thermal desorption-delayed purging sample injection method for drug mixture detection
  • Light flash thermal desorption-delayed purging sample injection method for drug mixture detection
  • Light flash thermal desorption-delayed purging sample injection method for drug mixture detection

Examples

Experimental program
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Effect test

Embodiment 1

[0055] The above method is applied, the sample is passed through a 1μL injection needle, and 1μg / mL narcotine is spotted on the tetrafluorocloth, the absolute mass is 1ng, and then the tetrafluorocloth is inserted into the figure 1 in the device shown. image 3 The ion trap mass spectrum of 1ng remifentanil was obtained by using halogen lamp flash analysis-delayed purge injection. The halogen lamp flash time is 2s, and the intensity can reach about 400.

[0056] Figure 4 Also using the same method, the ion trap mass spectrum of 1ng narcotine obtained by halogen lamp flash analysis-delayed purge injection, the halogen lamp flash time is 2s, and the intensity can reach about 400.

Embodiment 2

[0058] Above-mentioned method is applied, has prepared the mixture of 10 kinds of drugs with different boiling points, and table 1 is their absolute mass and molecular weight, Figure 5 It is the mixture of these ten kinds of drugs with different boiling points that adopts halogen light flash heat analysis-delayed purging when the detection results are inserted into the peek cavity with polyethylene tetrafluorocloth, which is the working sequence figure 2 The change of time in step (5). It can be seen that ten kinds of drug mixtures can be detected at the same time starting from 0s, and these ten kinds of drugs have a higher intensity from 0s to 3s, which realizes the simultaneous detection of a variety of difficult and volatile drug mixtures purpose of designation.

[0059] Table 1 Ten drug mixtures

[0060]

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Abstract

The invention discloses a light flash thermal desorption-delayed purging sample injection method for rapidly and simultaneously detecting volatile and non-volatile drug mixtures. A plurality of typesof drugs exist, and are large in difference of the structures and the molecular weights; and some drugs, which are not easy to volatilize, can reduce the sensitivity of a drug detection instrument utilizing thermal desorption sample injection, and meanwhile, influence the detection and identification efficiency of opium or new psychologically active drug mixtures. According to the method, the problem of rapid and simultaneous detection of the volatile-non-volatile drug mixture is solved; a halogen lamp is used for flash heating, so that the drug mixture is rapidly heated, the vapor pressure ofthe mixed sample is increased, the ionization efficiency at normal pressure is improved, and the signal intensity of the non-volatile sample in the mixture is improved by one order of magnitude or more; and by combining with a delayed purging device, the non-volatile and volatile substances volatilized during flash heating are purged into an ionization cavity at the same time, so that the loss ofsamples in the continuous purging and heating process is reduced, and the simultaneous detection of non-volatile and volatile drugs is realized.

Description

technical field [0001] The invention relates to a mass spectrometry instrument, which essentially uses a halogen lamp to simultaneously heat the mixture of volatile and refractory drugs, which can greatly increase the saturated vapor pressure of refractory drugs in the drug mixture, thereby improving its ionization efficiency and making difficult The signal intensity of volatile samples increased by more than an order of magnitude. The installed delay purge device realizes that the hard-to-volatilize and volatile drugs volatilized during the flash heat are purged into the ionization chamber at the same time, which reduces the purge loss of the sample during the continuous purge heating process. Background technique [0002] Common instrumental analysis methods for mixtures are mainly a certain pretreatment method combined with chromatographic separation technology. Chromatographic techniques mainly include gas chromatography (GC) and liquid chromatography (LC). In order to ...

Claims

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Application Information

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IPC IPC(8): H01J49/04H01J49/00G01N27/64
CPCG01N27/64H01J49/0031H01J49/0459H01J49/049
Inventor 李海洋侯可勇王伟民王爽
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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