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Multifunctional intelligent composite gel material as well as preparation method and application thereof

A composite gel, multi-functional technology, applied in medical science, bandages, etc., can solve the problems of poor stretch recovery, no environmental responsiveness, lack of antibacterial properties and tissue viscosity, and inability to effectively use wound dressings, etc., to promote raw materials. Source, promote wound healing, low equipment requirements

Active Publication Date: 2020-04-28
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these hydrogels also have the problems of poor stretch recovery and no environmental responsiveness, lack of antibacterial properties and tissue adhesion, and mismatch between mechanics and tissues, so they cannot be effectively used in the field of wound dressings.

Method used

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  • Multifunctional intelligent composite gel material as well as preparation method and application thereof
  • Multifunctional intelligent composite gel material as well as preparation method and application thereof
  • Multifunctional intelligent composite gel material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Dissolve calcium chloride and corn starch in water, the mass fractions of the solution are 20% and 13.3%, respectively, heated in a 60℃ water bath for 30 minutes to form a starch-based elastic conductive colloid.

[0042] Dissolve 13% acrylamide in water, add 0.008%, 0.006% and 0.02% N,N'-methylenebisacrylamide, N,N,N',N'-tetramethyl Ethylenediamine and ammonium persulfate are stirred evenly to form a PAM hydrogel precursor.

[0043] The starch-based elastic conductive colloid and the PAM hydrogel precursor are mixed uniformly at a mass ratio of 1:1, and heated in a water bath at 60°C for 30 minutes to form a gel material.

[0044] Place the prepared gel material on the joints of the fingers and perform bending and extension activities at the same time. figure 1 , The results of the morphology of the gel material prepared in this example and the fit of the skin at the joints show the photos, by figure 1 It can be seen that the gel material has a good fit with the skin at the j...

Embodiment 2

[0049] Dissolve copper nitrate and sweet potato starch in water with a mass fraction of 10% and 18%, respectively, and heat in a water bath at 80 ℃ to form a starch-based elastic conductive colloid.

[0050] Dissolve 15% mass fraction of acrylamide in water, add 0.008% and 0.02% N,N'-methylenebisacrylamide and sodium persulfate, stir evenly to form PAM hydrogel precursor .

[0051] The prepared starch-based elastic conductive colloid and PAM hydrogel precursor were mixed uniformly at a mass ratio of 1:2, and heated in a water bath at 60 ℃ for 30 min to form a gel material.

[0052] The direct contact method was used to test the antibacterial properties of the gel material. The formula for calculating the antibacterial rate is as follows:

[0053] ,

[0054] In the formula: R is the antibacterial rate (%); A is the average number of bacteria planted on the surface of the tested bacteria (CFU / mL); B is the average number of bacteria (CFU / mL) after the test sample has been in contact wi...

Embodiment 3

[0057] Dissolve calcium chloride and strontium nitrate in water according to the mass ratio of 5% and 10% of the solution, then add corn starch with a mass fraction of 20%, and heat it in a 60 ℃ water bath to form a starch-based elastic conductive colloid. Add 5 mL with a mass fraction of 0.1 % Bromophenol blue solution, stir evenly to simulate drug release.

[0058] Dissolve 15% acrylamide in water, add 0.006% and 0.01% N,N-N,N'-methylenebisacrylamide and ammonium persulfate, and mix well to form PAM water Gel precursor.

[0059] The prepared starch-based elastic conductive colloid and PAM hydrogel precursor were mixed uniformly at a mass ratio of 2:1, and heated in a water bath at 80 ℃ for 60 min to form a gel material.

[0060] The gel material was made into a cube with an area of ​​1 cm*1 cm and a thickness of 1 mm, which was placed in deionized water, and the release of bromophenol blue in the dressing was tested with a microplate reader at regular intervals. The experimental ...

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Abstract

The invention discloses a multifunctional intelligent composite gel material as well as a preparation method and application thereof. The preparation method includes the steps of: heating starch in aninorganic salt aqueous solution to form starch-based elastic conductive colloid; then forming a multifunctional intelligent composite gel material by using the hydrogel and a PAM or PVA hydrogel precursor, wherein the adhesion strength of the adhesive to animal tissues or epidermis is 0.5-15 kPa and the growth of staphylococcus aureus, escherichia coli, pseudomonas aeruginosa and candida albicansis inhibited. The prepared hydrogel has good biocompatibility and electrical conductivity of 0.0005-100 ms / cm, has rapid and stable responsiveness to stress / strain and temperature as well as an environment-responsive drug slow release function and a touch response function, and has application potential in the fields of wound dressings, intelligent drug slow release, wound monitoring, electronicskin, wearable flexible electronic skin and the like. The preparation method of the gel material provided by the invention is simple, convenient and green, wide in raw material source, low in equipment requirement and low in production cost.

Description

Technical field [0001] The invention relates to a multifunctional hydrogel, a preparation method and application, and in particular to a smart gel material with anti-infection, promotion of wound healing and multimodal responsiveness, a preparation method and application. [0002] technical background [0003] Hydrogels play an important role in many fields such as biomedicine, sewage treatment, smart sensing, and electromechanical industries. As an emerging dressing, hydrogel dressings are very popular in the market. However, the hydrogel dressings currently on the market have a single function and lack antibacterial properties. For example, alginate dressings have low elasticity and poor antibacterial properties, chitosan dressings are expensive and have immunogenicity problems (see literature: Elbadawy A. Kamoun, El-Refaie S. Kenawy, Xin Chen. Areview on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings[J]. Journal of Advanced Research,...

Claims

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Application Information

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IPC IPC(8): C08L33/26C08L3/02C08J3/075C08L29/04A61L26/00
CPCC08J3/075A61L26/0014A61L26/0023A61L26/008A61L26/0066A61L26/0061C08J2333/26C08J2403/02C08J2433/26C08J2303/02C08J2329/04C08J2429/04A61L2300/602C08L33/26C08L29/04C08L3/02Y02A50/30
Inventor 杨磊林潇毛雨轩白艳洁陈涛李鹏
Owner SUZHOU UNIV
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