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A kind of high-performance biodegradable zn-cu-li-x alloy and its preparation and application method

A zn-cu-li-x, high-performance technology, used in the design and preparation of biodegradable medical materials, can solve the problems of lack of supply and addition of Li, and achieve wide application prospects, easy processing and forming, and low alloy cost. Effect

Active Publication Date: 2021-04-06
北京尚宁科智医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] In summary, the prior art literature does not provide information on the addition of Li to Zn-Cu alloys to simultaneously improve the properties of the alloy to a yield strength higher than 200 MPa and a tensile strength higher than 300 MPa

Method used

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  • A kind of high-performance biodegradable zn-cu-li-x alloy and its preparation and application method
  • A kind of high-performance biodegradable zn-cu-li-x alloy and its preparation and application method
  • A kind of high-performance biodegradable zn-cu-li-x alloy and its preparation and application method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: Preparation and performance test of biodegradable Zn-Cu-Li-X quaternary alloy.

[0037] The mass percentage of each chemical element in the biodegradable Zn-Cu-Li-X quaternary alloy is shown in Table 1-1, and the balance is Zn. The alloy preparation process is vacuum induction smelting→homogenizing heat treatment→preheating→hot rolling or extrusion. The vacuum induction smelting uses high-purity block Zn, Zn-Cu intermediate alloy, high-purity block Li and materials containing X elements as raw materials, and the ingredients are added to the crucible according to the mass percentage, and the vacuum is pumped to 10Pa and filled with argon protection. Turn on the power supply, gradually increase the power to 5KW, and after 5 minutes at 600°C, pour it into the graphite mold.

[0038] Homogenization treatment: place the alloy ingot in a box-type heating and sintering furnace KSL-1400X, raise the temperature to 220°C at a rate of 2°C / min, and keep it for 1 hour; t...

Embodiment 2

[0049] Example 2: Preparation and performance test of biodegradable Zn-Cu-Li-X quinary alloy.

[0050] The mass percentage of each chemical element in the biodegradable Zn-Cu-Li-X quinary alloy is shown in Table 2-1, and the balance is Zn. The preparation process of the degradable quinary alloy is vacuum induction smelting→homogenizing heat treatment→preheating→hot rolling or extrusion. Melting and homogenization heat treatment were carried out according to the method provided in Example 1. After homogenization heat treatment, the microstructure of the Zn-Cu-Li-X quinary alloy is composed of fine and dense Zn+β-LiZn 4 Sheets, Cu-rich matrix and its nano-scale precipitates containing X elements. Samples were cut from the obtained profiles to test in vitro corrosion, cytotoxicity and tensile mechanical properties at room temperature. The preparation and testing methods of the above samples were carried out according to the method provided in Example 1.

[0051] It is measure...

Embodiment 3

[0056] Example 3: Preparation and performance test of biodegradable Zn-Cu-Li-X six-element alloy.

[0057] The mass percentage of each chemical element in the biodegradable Zn-Cu-Li-X six-element alloy is shown in Table 3-1, and the balance is Zn. The preparation process of the degradable six-element alloy is vacuum induction melting→homogenizing heat treatment→preheating→hot rolling or extrusion or drawing. Melting and homogenization heat treatment were carried out according to the method provided in Example 1. After homogenization heat treatment, the microstructure of the Zn-Cu-Li-X six-element alloy is composed of fine and dense Zn+β-LiZn 4 Sheets, Cu-rich matrix and its nano-scale precipitates containing X elements. Samples were cut from the obtained profiles to test in vitro corrosion, cytotoxicity and tensile mechanical properties at room temperature. The preparation and testing methods of the above samples were carried out according to the method provided in Example ...

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Abstract

A high-performance biodegradable Zn-Cu-Li-X alloy and its preparation and application method belong to the field of biodegradable medical materials. In the Zn-Cu-Li-X alloy of the present invention, X is one of Mg, Ca, Sr, Mn, Fe, Ag, Co, Cr, Ti, Sn, Si, Se and Ge, and Zn is the balance. After vacuum melting, high temperature homogenization treatment, preheating, and plastic deformation, fine and dense nano-precipitated phases, or elemental elements, or Zn+β-LiZn are obtained 4 The continuous lamellar structure and Cu-rich phase make the alloy have both high strength and high plasticity. The room temperature tensile yield strength of the alloy is 250-650MPa, the tensile strength is 300-800MPa, and the elongation is 20-80%; it is uniformly degraded in simulated body fluid, and the degradation rate is 0.011-0.5mm / y; The toxicity of bone fibroblasts and MG63 cells is lower than grade 2, which meets the requirements for the use of a variety of human implant materials, and has promotional value and broad application prospects.

Description

technical field [0001] The invention relates to a design and preparation method of a biodegradable medical material, in particular to a composition design, heat treatment and plastic deformation method of a high-performance biodegradable Zn-Cu-Li-X alloy. [0002] technical background [0003] In recent years, in order to solve the problem of secondary surgical removal of existing clinical metal inert implant materials (316L stainless steel, Ti6Al4V, etc.), research on Fe, Mg, Zn and other degradable metal materials has gradually become a research hotspot in medical materials. Among them, degradable Zn metal has become a new research focus of biomedical degradable materials due to its degradation rate compatible with the recovery rate of human tissue (the standard electrode potential of Zn is -0.763V, which is between Mg and Fe). However, due to the low strength and poor plasticity of Zn and its alloys, its application and development are severely limited. [0004] Selecting...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C22C18/02C22C18/00C22F1/16
CPCC22C18/00C22C18/02C22F1/165
Inventor 王鲁宁李祯石章智李华芳李婷
Owner 北京尚宁科智医疗器械有限公司
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