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Chitosan grafted polylactic acid copolymer, and preparation method and application thereof

A polylactic acid copolymer and chitosan technology, applied in the field of degradable biomass materials, can solve the problems of low grafting rate, high catalyst dosage, long time consumption, etc., and achieve low dosage, excellent solubility, and short polymerization time. Effect

Active Publication Date: 2020-04-17
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the reaction of chitosan-grafted polylactic acid usually takes more than ten to twenty hours, which takes a long time, and most of them use stannous octoate as the catalyst. The amount of catalyst is high, but the grafting rate is low.

Method used

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  • Chitosan grafted polylactic acid copolymer, and preparation method and application thereof
  • Chitosan grafted polylactic acid copolymer, and preparation method and application thereof
  • Chitosan grafted polylactic acid copolymer, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 0.2g chitosan and 4g EMIMAc were put into a dry 50ml three-necked flask, vacuumed three times with nitrogen; the temperature was raised to 100°C, and vigorously stirred for 3h under a nitrogen atmosphere to obtain a homogeneous solution; subsequently, the solution was cooled to At room temperature, slowly add 7.072g D,L-lactide monomer (the molar ratio of D,L-lactide monomer: glucosamine unit in chitosan is 40:1) and 0.0354g DMAP; then repeat Vacuum, nitrogen-filled nitrogen pumping process three times. The temperature was raised to 100°C, and vigorously stirred for 5 hours under a nitrogen atmosphere to obtain a reaction solution; after the reaction solution was cooled to room temperature, the copolymer was precipitated by adding 10 times the volume of the reaction solution in absolute ethanol; finally, purified by acetone extraction Copolymer for 24 hours, remove D,L-lactide monomer self-polymerized, PDLLA homopolymer not grafted on chitosan; dry the purified copolyme...

Embodiment 2

[0041] Put 0.2g chitosan and 4g EMIMAc into a dry 50ml three-necked flask, vacuum three times with nitrogen; raise the temperature to 100°C, stir vigorously under nitrogen atmosphere for 3h to obtain a homogeneous solution. Subsequently, the solution was cooled to room temperature, and 1.768 g of D, L-lactide monomer was slowly added (the molar ratio of D, L-lactide monomer: glucosamine unit in chitosan = 10:1) and 0.0088g DMAP. The evacuated, nitrogen-filled nitrogen pumping process was then repeated three times. The temperature was raised to 100°C, and vigorously stirred for 5 hours under a nitrogen atmosphere to obtain a reaction solution; after the reaction solution was cooled to room temperature, the copolymer was precipitated by adding 10 times the volume of the reaction solution in absolute ethanol; finally, purified by acetone extraction Copolymer for 24 hours, remove D,L-lactide monomer self-polymerized, PDLLA homopolymer not grafted on chitosan; dry the purified cop...

Embodiment 3

[0045]0.2g chitosan and 4g EMIMAc were put into a dry 50ml three-necked flask, vacuumed three times with nitrogen; the temperature was raised to 100°C, and vigorously stirred for 3h under a nitrogen atmosphere to obtain a homogeneous solution; subsequently, the solution was cooled to At room temperature, 3.536g of D,L-lactide monomer (the molar ratio of D,L-lactide monomer:glucosamine unit in chitosan is 20:1) and 0.0177g of DMAP were slowly added. The evacuated, nitrogen-filled nitrogen pumping process was then repeated three times. The temperature was raised to 100°C, and vigorously stirred for 5 hours under a nitrogen atmosphere to obtain a reaction solution; after the reaction solution was cooled to room temperature, the copolymer was precipitated by adding 10 times the volume of the reaction solution in absolute ethanol; finally, purified by acetone extraction Copolymer for 24 hours, remove D,L-lactide monomer self-polymerized, PDLLA homopolymer not grafted on chitosan; d...

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Abstract

The invention discloses a chitosan grafted polylactic acid copolymer, and a preparation method and an application thereof. The preparation method comprises the following steps: (1) adding chitosan into an ionic liquid EMIMAc, and heating and stirring to obtain a uniform chitosan solution; and (2) adding a D,L-lactide monomer and a catalyst DMAP into the uniform chitosan solution prepared in step (1), and carrying out a reaction at a reaction temperature of 100 + / -5 DEG C for 5 + / -0.1 h to obtain the chitosan grafted polylactic acid copolymer. When the grafting amount of the polylactic acid islow, the grafted copolymer can be dissolved in water and an organic solvent; and when the grafting amount of polylactic acid is high, the grafted copolymer cannot be dissolved in water and can only bedissolved in the organic solvent. The grafted copolymer prepared in the invention has good film-forming property; and copolymers with different polylactic acid grafting amounts have different degradation rates, so that controllable degradation of the chitosan grafted polylactic acid copolymer can be realized.

Description

technical field [0001] The invention belongs to the technical field of degradable biomass materials, and in particular relates to a chitosan-grafted polylactic acid copolymer and its preparation method and application. Background technique [0002] Biodegradable polymers are increasingly used in biomedical applications such as drug sustained-release materials, wound dressings, and tissue engineering scaffolds. Biodegradable polymers as drug sustained-release materials should have good biocompatibility, good biodegradability, controllable degradation and stable drug release rate. Polylactic acid (PLA) is a promising biodegradable polymer obtained through the polymerization of lactic acid, which is generally fermented from sugars extracted from corn and cassava, which is an abundant and renewable raw material. Polylactic acid has three stereoconfigurations, including poly-L-lactic acid (PLLA), poly-D-lactic acid (PDLA) and poly-desmic lactic acid (PDLLA). Since PDLLA has a n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/08C08G63/87C08J5/18C08L67/04
CPCC08G63/08C08G63/823C08J5/18C08J2367/04
Inventor 孙倩玉杨仁党
Owner SOUTH CHINA UNIV OF TECH
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