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Polydopamine-coated Prussian blue and silver-loaded nano-composite material, and preparation method and application thereof

A nano-composite material, Prussian blue technology, is applied in the field of polydopamine-coated Prussian blue-loaded silver nano-composite material and its preparation, which can solve the problems of small size of silver nanometers, limited antibacterial efficiency, large specific surface area, etc. Improved antibacterial effect, high spatial resolution effect

Inactive Publication Date: 2020-04-14
HUNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the small size and large specific surface area of ​​individual silver nanoparticles, the tendency to aggregate greatly limits their antibacterial efficiency.

Method used

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  • Polydopamine-coated Prussian blue and silver-loaded nano-composite material, and preparation method and application thereof
  • Polydopamine-coated Prussian blue and silver-loaded nano-composite material, and preparation method and application thereof
  • Polydopamine-coated Prussian blue and silver-loaded nano-composite material, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0043] A polydopamine-wrapped Prussian blue silver-loaded nanocomposite material of the present invention, the nanocomposite material is mainly composed of Prussian blue, polydopamine and nano-silver, polydopamine is wrapped on the Prussian blue, and nano-silver is grown on the package of Prussian blue in situ Layer polydopamine on. The particle size of the nanocomposite material is in the range of 100nm to 150nm.

[0044] A kind of preparation method of polydopamine wrapping Prussian blue silver-loaded nanocomposite material of above-mentioned present embodiment, comprises the following steps:

[0045] (1) Preparation of Prussian blue dispersion

[0046] Dissolve 264mg of potassium ferricyanide and 3g of polyvinylpyrrolidone in 40mL of 0.01M HCl solution, the pH of the HCl solution is 2, then heat the resulting yellow mixture in an oil bath at 80°C for 20 hours, and then The product solution obtained by the reaction was centrifuged at a speed of 12000rpm for 15min, the prec...

Embodiment 2

[0055] An application of the polydopamine-wrapped Prussian blue silver-loaded nanocomposite material of the present invention in the preparation of photothermal antibacterial drugs, using the polydopamine-wrapped Prussian blue silver-loaded nanocomposite material prepared in Example 1.

[0056] Such as Figure 5 As shown, 100 μL of Prussian blue dispersion with a concentration of 200 μg / mL, polydopamine-wrapped Prussian blue dispersion, and polydopamine-wrapped Prussian blue silver-loaded nanocomposite dispersion (both dispersed with deionized water) were used to treat methoxide-resistant Xilin Staphylococcus aureus 30min, the group with near-infrared light irradiation uses 1W / cm 2 , 808nm near-infrared light (NIR) irradiated for 5min, and the results showed that the single polydopamine-wrapped Prussian blue silver-loaded nanocomposite could only kill 66.70% of bacteria, while the polydopamine-wrapped Prussian blue silver-loaded nanocomposite combined with near-infrared light ...

Embodiment 3

[0058] An application of the polydopamine-wrapped Prussian blue silver-loaded nano-composite material of the present invention in the preparation of chronic traumatic infection treatment drugs, using the polydopamine-wrapped Prussian blue silver-loaded nano-composite material prepared in Example 1.

[0059] Such as Figure 7 and Figure 8 As indicated, common wounds infected by methicillin-resistant Staphylococcus aureus were treated with 100 μL of Prussian blue dispersion at a concentration of 200 μg / mL, polydopamine-coated Prussian blue dispersion, and polydopamine-coated Prussian blue silver-loaded nanocomposite dispersion and chronic wounds of diabetic mice, the group irradiated with near-infrared light was treated with 1W / cm 2 , 808nm near-infrared light irradiation for 5 minutes, the results showed that compared with the control group, Prussian blue silver-loaded nanocomposites combined with near-infrared light treatment had the highest efficiency in promoting wound hea...

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Abstract

The invention discloses a polydopamine-coated Prussian blue and silver-loaded nano-composite material, and a preparation method and an application thereof. The composite material is formed by coatingPrussian blue with polydopamine and then growing nano-silver on the polydopamine in situ, and the particle size of the composite material is 100-150 nm. The preparation method comprises the followingsteps: reacting potassium ferricyanide with polyvinylpyrrolidone to obtain Prussian blue, adding dopamine into a Tris-HCl solution of Prussian blue to prepare polydopamine-coated Prussian blue, and mixing and stirring the obtained polydopamine-coated Prussian blue dispersion, ammonia water, a reducing agent and a silver nitrate solution to react in order to make nano-silver grows on the coating layer polydopamine in situ in order to obtain the product. The nano-composite material has a good antibacterial effect, is not prone to causing drug resistance of bacteria, has good stability and dispersity, the preparation method has the advantages is simple and mild, short in time consumption, low in energy consumption and easy to realize large-scale production, and the nano-composite material canbe used for preparing photo-thermal antibacterial drugs or chronic traumatic infection treatment drugs.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to an antibacterial nanocomposite material and its preparation method and application, in particular to a polydopamine-wrapped Prussian blue silver-loaded nanocomposite material and its preparation method and application. Background technique [0002] Traditional antibiotics are the most widely used treatment for bacterial infections, yet the emergence of antibiotic resistance often leads to incurable bacterial diseases, most likely due to biofilm formation. Meanwhile, infections caused by multidrug-resistant (MDR) bacteria are becoming a great challenge in clinical treatment, especially for chronic non-healing wound infections, which increases the morbidity and mortality of patients. Unfortunately, so far, there are few relevant reports on effective therapies for chronic wound infections. Therefore, there is still a great need to develop effective strategies to deal with the curr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K33/38A61K47/34A61K47/69A61P17/02A61P31/04
CPCA61K33/38A61K41/0052A61K47/34A61K47/6925A61P17/02A61P31/04A61K2300/00
Inventor 周苹刘斌钟祥华童春义
Owner HUNAN UNIV
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