Hydroxypropyl starch empty capsule and preparation method thereof

A technology of hydroxypropyl starch and hollow capsules, which is applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., and can solve the problems of hollow capsule disintegration, delayed dissolution of capsule contents, poor water solubility of capsules, gelatin capsules, etc. Easy to become brittle and other problems, to achieve the effect of superior processing flow performance, improve film forming and plasticity, and reduce the risk of brittle and broken

Inactive Publication Date: 2020-04-14
河南新孚望新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Our country needs about 250 billion medicinal capsules every year, and more than 95% of them are animal gelatin capsules. It has been found that, for example: 1. Gelatin is easy to cross-link with drugs such as aldehydes, reducing sugar-based compounds and vitamin C, which makes the water solubility of capsules worse, leading to the disintegration of empty capsules and the delay of dissolution of capsule contents; Electrostatic charge accumulation can occur under dry conditions, which greatly affects subsequent production and processing; 3. When stored in a low-humidity environment for a long time, gelatin capsules tend to become brittle and cause the capsules to break; 4. Gelatin is an animal-derived component. factors, thus making gelatin rejected by certain groups of people in the world

Method used

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  • Hydroxypropyl starch empty capsule and preparation method thereof

Examples

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Effect test

Embodiment 1

[0028] A hydroxypropyl starch hollow capsule, in parts by weight, the hydroxypropyl starch hollow capsule comprises the following components: 100 parts of hydroxypropyl starch, 15 parts of konjac gum, 2 parts of potassium chloride, 0.5 parts of glycerin, nano 0.8 parts of superfine calcium carbonate, 1000 parts of pure water.

[0029] A preparation method for hydroxypropyl starch hollow capsules, comprising the following steps:

[0030] (1) Mixed sol: mix hydroxypropyl starch, gelling agent, and coagulant aid with water in proportion, stir evenly and put it in a water bath set at 70°C to 80°C to gelatinize the starch, keep warm while stirring , After 70-100 minutes, take it out and cool down, add glycerin and nano-ultrafine calcium carbonate, stir evenly to form a glue, and let it stand for 120-160 minutes to remove the air bubbles in the glue.

[0031] (2) Dip in glue to make a blank: put the glue in a fully automatic hollow capsule manufacturing machine, and dip the die rod...

Embodiment 2

[0037] The difference between this example and Example 1 is that the hydroxypropyl starch hollow capsule includes the following components: 105 parts of hydroxypropyl starch, 22 parts of carrageenan, 2 parts of potassium chloride, 1 part of glycerin, nanometer super 1 part of fine calcium carbonate, 1100 parts of pure water.

Embodiment 3

[0039] The difference between this example and Example 1 is that the hydroxypropyl starch hollow capsules include the following components: 110 parts of hydroxypropyl starch, 25 parts of konjac gum, 3 parts of potassium chloride, 1.5 parts of glycerin, nanometer super 1.5 parts of fine calcium carbonate, 1200 parts of pure water.

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Abstract

The invention discloses a hydroxypropyl starch empty capsule, which is prepared from the following components (by weight): 100-110 parts of hydroxypropyl starch, 15-25 parts of gel, 2-3 parts of coagulant aids, 0.5-1.5 parts of a plasticizer, 0.8-2 parts of nanometer superfine calcium carbonate and 1000-1200 parts of water. Meanwhile, the invention further discloses a preparation method of the hydroxypropyl starch empty capsule. The empty capsule prepared by the preparation method has high toughness, is not easy to break and has good stability; in addition, the raw materials are cheap in price, the cost is low, and there is no environmental pollution in the production process.

Description

technical field [0001] The invention relates to the technical field of starch modification, in particular to a hydroxypropyl starch hollow capsule and a preparation method thereof. Background technique [0002] Ordinary capsules can be divided into hard capsules and soft capsules, and hard capsules are also called "hollow capsules". The hollow capsule is composed of a cap and a body two-section capsule shell refined from gelatin and auxiliary materials. It is mainly used to hold solid and liquid medicines. , Capsules can also effectively mask the unpleasant taste and smell of the contents, and are the most popular dosage form for consumers. [0003] Our country needs about 250 billion medicinal capsules every year, and more than 95% of them are animal gelatin capsules. It has been found that, for example: 1. Gelatin is easy to cross-link with drugs such as aldehydes, reducing sugar-based compounds and vitamin C, which makes the water solubility of capsules worse, leading t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/36
CPCA61K9/4816A61K47/36
Inventor 马德敏丁世海孙春芳谢军红张亚蕊
Owner 河南新孚望新材料科技有限公司
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