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Polyhydroxy-containing polymer and preparation method and application thereof

A technology of polymer and hydroxyl, which is applied in application, drug delivery, pharmaceutical formulation, etc., can solve the problems of limited curative effect and few products on the market, and achieve the effect of strong adhesion and good biocompatibility

Active Publication Date: 2020-04-07
NOVA ADVANCED MATERIALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the curative effect of the microsphere embolization is limited by the interventional physician's personal intubation technique; different lesion locations have different requirements for the particles of the microspheres, and the influence of the swelling rate and swelling pressure of the microspheres also needs to be considered
Therefore, there are many research reports on embolization microspheres, but there are few marketed products that are actually used clinically.

Method used

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  • Polyhydroxy-containing polymer and preparation method and application thereof
  • Polyhydroxy-containing polymer and preparation method and application thereof
  • Polyhydroxy-containing polymer and preparation method and application thereof

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preparation example Construction

[0049] The preparation method of the present invention will be further described in detail in conjunction with specific examples below. It should be understood that the following examples are only for illustrating and explaining the present invention, and should not be construed as limiting the protection scope of the present invention. All technologies realized based on the above contents of the present invention are covered within the scope of protection intended by the present invention.

[0050] The experimental methods used in the following examples are conventional methods unless otherwise specified; the reagents and materials used in the following examples can be obtained from commercial sources unless otherwise specified.

[0051] Material Structure Test 1 HNMR, 13 CNMR was measured by a 600-megapulse Fourier transform nuclear magnetic resonance spectrometer from JOEL; IR was measured by a Fourier transform infrared spectrometer nicolet is50 from Thermofisher; the Tg...

Embodiment 1

[0054] Polybutadiene: commercial polybutadiene block (purchased from Sichuan Petrochemical Co., Ltd., 1,4-cis content ≥ 98%, and 2% 1,4-trans and the structure shown in formula 4 ; Number average molecular weight ) into about 2mm rubber particles.

[0055] Epoxidation: In a 250ml three-necked flask equipped with a stirrer and a thermometer, add 7g of the above-mentioned polybutadiene colloidal particles and 100ml of dichloromethane. Dissolve and stir in a constant temperature water bath. When it is completely dissolved into a viscous shape, nitrogen gas is introduced for several minutes. Add 9.90g of formic acid, and dropwise add 21.40g of 30% hydrogen peroxide aqueous solution while stirring; continue the heat preservation reaction for about 15h, 1 HNMR (CDCl 3 ) analysis, the 1,4-cis double bond characteristic chemical shift peak disappeared (epoxy group characteristic chemical shift δ=2.98, 1,4-cis double bond characteristic chemical shift δ=5.40). The reaction product...

Embodiment 2

[0058] Polybutadiene: Add 180ml of dry petroleum ether (60-90°C) to a 500ml anhydrous and oxygen-free reaction bottle, and dry 1,3-butadiene (Chengdu Keyuan Gas Co., Ltd., purity greater than or equal to 99.5%), absorbed to butadiene 20g. Seal the reaction bottle, put it in a water bath at 40°C, inject 0.4ml of the aging solution of nickel naphthenate and triisobutylaluminum while stirring, and then inject 0.38ml of BF 3 Diethyl ether complex and 0.4ml of n-octanol were stirred for 2h, and 2ml of ethanol was added to terminate the reaction. 200ml of absolute ethanol was added to the reaction solution, and a solid gel was precipitated. After drying, 19 g of polycis-1,4-butadiene was obtained. GPC analysis polybutadiene number average molecular weight 91000. As determined by HNMR, the cis-1,4 double bond ratio is 98.5%, and the gel content is less than 0.1%.

[0059] Epoxidation: step is with embodiment 1.

[0060] Hydrolysis: Step Example 1.

[0061] The prepared solid pr...

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Abstract

The invention relates to a polyhydroxy-containing polymer and a preparation method and application thereof. The polymer has good biocompatibility, and has strong bonding performance substances which contain oxygen, nitrogen and the like on the surface and are easy to form hydrogen bonds. A solution formed by the polymer has poor cohesiveness with a microcatheter for intubation, but strong cohesiveness with blood vessels, skin and glass, and can be used as a vascular embolization agent.

Description

technical field [0001] The invention belongs to the field of macromolecular materials, and in particular relates to a polyhydroxyl-containing polymer, a preparation method thereof and an application in blood vessel embolism. Background technique [0002] Interventional therapy is one of the fastest-growing medical disciplines in the 21st century, and it has now kept pace with internal medicine and surgical treatment, becoming the third treatment system. Embolization is an important part of interventional therapy. It is a minimally invasive treatment using modern high-tech means. Embolization therapy is to inject emboli into diseased organs in a controlled manner through arterial or intravenous catheters under the guidance of medical imaging equipment. In the blood supply of blood vessels, it will be occluded and the blood supply will be interrupted, so as to achieve the purpose of controlling bleeding, treating tumors and vascular lesions, and eliminating the function of dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08C19/06C08C19/00C08C19/02A61L24/04
CPCC08C19/06C08C19/00C08C19/02A61L24/046C08F8/12A61L2430/36A61L24/001A61L2400/06A61L24/06
Inventor 代俊明杨建春杨冬梅韩凯朱荣欣
Owner NOVA ADVANCED MATERIALS CO LTD
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