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Artemisia ordosica root extract and preparation method and application thereof

The technology of root extract and Artemisia syringae, which is applied in the field of Artemisia syringae root extract and its preparation, can solve the problems not involved in the preparation method and application of anti-allergic rhinitis extract, and achieve good effect, no toxic side effects, The effect of reducing infiltration

Active Publication Date: 2020-04-07
肖斌 +8
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

None of the patents at home and abroad involve the preparation method and application of the anti-allergic rhinitis extract from the root of Artemisia annua

Method used

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  • Artemisia ordosica root extract and preparation method and application thereof
  • Artemisia ordosica root extract and preparation method and application thereof
  • Artemisia ordosica root extract and preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0032] A preparation method for the root extract of Artemisia sageris, comprising the following steps:

[0033] (1) Weigh 0.5 parts of Artemisia syringae roots, dry and pulverize them, add 8 times the weight of Artemisia sagerii roots to 60% ethanol solution for ultrasonic extraction, the extraction time is 60min, and the ratio of solid to liquid is 20: 1ml / g , ultrasonic power 200W; then the extracts were combined and concentrated and dried at 55°C for 30 minutes to obtain extract A;

[0034] (2) Extract A is dissolved in distilled water with 8 times its weight to obtain the extract A solution; then the extract A solution is extracted twice with equal volumes of petroleum ether, ethyl acetate and n-butanol successively to obtain Petroleum ether layer extract, ethyl acetate layer extract, n-butanol layer extract, and water-soluble matter; the ethyl acetate layer extract was collected, concentrated under reduced pressure, and dried at 85°C to obtain the Artemisia annua root ext...

Embodiment 2

[0036] A preparation method for the root extract of Artemisia sageris, comprising the following steps:

[0037] (1) Weigh 2 parts of the roots of Artemisia syringae, after drying and crushing, add 13 times the weight of the roots of Artemisia syringae to 75% ethanol solution for ultrasonic extraction, the extraction time is 120min, and the ratio of solid to liquid is 50: 1ml / g , with an ultrasonic power of 600W; then the extracts were combined and concentrated and dried at 70°C for 40 minutes to obtain Extract A;

[0038] (2) Extract A is dissolved with 13 times of its weight in distilled water to obtain extract A solution; then extract A solution is extracted 5 times with equal volumes of sherwood oil, ethyl acetate and n-butanol successively to obtain Petroleum ether layer extract, ethyl acetate layer extract, n-butanol layer extract and water soluble matter; the ethyl acetate layer extract was collected, concentrated under reduced pressure, and dried at 105°C to obtain the ro...

Embodiment 3

[0040] A preparation method for the root extract of Artemisia sageris, comprising the following steps:

[0041] (1) Weigh 1 part of Artemisia syringae root, after drying and crushing, add 10 times the weight of Artemisia sagerii root to 95% ethanol solution for ultrasonic extraction, the extraction time is 100min, and the ratio of solid to liquid is 35:1ml / g , ultrasonic power 400W; then the extracts were combined, concentrated and dried at 60°C for 35min to obtain extract A.

[0042] (2) Extract A is dissolved with 10 times of its weight in distilled water to obtain extract A solution; then extract A solution is extracted 3 times with equal volumes of sherwood oil, ethyl acetate and n-butanol successively to obtain Petroleum ether layer extract, ethyl acetate layer extract, n-butanol layer extract and water-soluble matter; the ethyl acetate layer extract was collected, concentrated under reduced pressure, and dried at 98°C to obtain the root extract of Artemisia annua.

[00...

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Abstract

The present invention discloses an artemisia ordosica root extract and a preparation method and an application thereof. The preparation method of the artemisia ordosica root extract comprises the following steps: drying and crushing artemisia ordosica roots and adding an ethanol solution for ultrasonic extraction; then mixing each extract and conducting concentrating and drying to obtain an extract A; and (2) dissolving the extract A with distilled water, and sequentially conducting extraction with petroleum ether, ethyl acetate and n-butanol; and collecting an ethyl acetate layer extract, andconducting concentration under reduced pressure and drying to obtain a finished product. The artemisia ordosica root extract contains 50-90% of total flavonoids, and eriodictyol, isosakuranetin, naringenin, hydroxygenkwanin, genkwanin, acacetin, diosmetin, glycitein, isorhamnetin, morin and quercetin with the total content of more than 2%. The artemisia ordosica root extract can obviously reduceallergic rhinitis symptoms of guinea pigs, also reduces levels of inflammatory factors of histamine, ovalbumin specific IgE, IL-2 / 4 / 10, IFN-gamma, ICam-1, etc. in serum of the guinea pigs, and can also reduce infiltration of eosinophilic granulocyte of nasal mucosa of nasal cavities of the guinea pigs.

Description

technical field [0001] The invention relates to a medicine, in particular to a root extract of Artemisia sageris and its preparation method and application. Background technique [0002] With the improvement of industrialization and the aggravation of urban air pollution, the incidence of allergic rhinitis is increasing year by year. Allergic rhinitis is a non-infectious chronic inflammatory disease of the nasal mucosa mainly mediated by IgE after the susceptible body is exposed to allergens. Episodic nasal itching, nasal congestion, sneezing and runny nose, poor control can induce otitis media, allergic conjunctivitis, nasal polyps, chronic sinusitis, and severe cases can cause asthma. Patients with allergic rhinitis suffer from the disease for a long time, not only affected physically, but also mentally damaged to a certain extent, which seriously reduces the quality of daily work and life of patients. Allergic rhinitis has become one of the key issues to be solved and o...

Claims

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Application Information

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IPC IPC(8): A61K36/282A61P11/02A61P37/08
CPCA61K36/282A61P11/02A61P37/08A61K2236/331A61K2236/55A61K2236/51
Inventor 肖斌苏伊新杜冠华折占飞王淑敏韩晓燕赵娜牛艺璇白埔
Owner 肖斌
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