Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pseudolaric acid B polylactic acid dispersion

A technology of acetic acid polylactic acid and eucalyptus acetic acid, which is applied in the field of preparation of pharmaceutical dispersions, can solve the problems of difficulty in applying long-term treatment of onychomycosis, easy crystallization and precipitation of eucalyptus acetic acid, poor medication compliance of patients, etc., and achieves reliable inhibition. Bacterial effect, treatment of bacterial infection, good biocompatibility effect

Inactive Publication Date: 2020-04-07
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned soil jing skin preparations contain relatively large amounts of salicylic acid, acetic acid, etc., which cause strong skin tingling and poor drug compliance of patients.
In addition, the solvents of the above-mentioned Vitex acetic acid preparations are mostly prepared with high-concentration ethanol. After the diseased nails are coated with the drug, the ethanol volatilizes, and the acetic acid of Vitex bark is easy to crystallize and separate out.
Although Tujing skin coating and sticking film can solve the problem of drug retention to a certain extent (Journal of External Treatment of Traditional Chinese Medicine, No. 2 in 1997), the water-soluble film material is easy to fall off, so it is difficult to be suitable for long-term treatment of onychomycosis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pseudolaric acid B polylactic acid dispersion
  • Pseudolaric acid B polylactic acid dispersion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Weigh 100g of polylactic acid fine powder, put it in a spherical flask, add 100ml 80% ethanol to suspend, then add 70mg of Vitex acetic acid, heat and reflux in a water bath until the Vitex acetic acid dissolves, cool down to 45°C, and evaporate under reduced pressure Solvent, grind the residue and transfer it to a mill for grinding and crushing, and pass through an 80-mesh pharmacopoeia sieve to obtain the product.

Embodiment 2

[0020] Weigh 100g of polylactic acid fine powder, put it in a spherical flask, add 100ml of absolute ethanol to suspend, then add 1.4g of Vitex acetic acid, stir and dissolve at room temperature, heat in a water bath to 42°C, evaporate the solvent under reduced pressure, and remove the residual The material is transferred to a ball mill for grinding and crushing, and passed through a 100-mesh pharmacopoeia sieve.

experiment example 1

[0022] Using alumina as a reference, weigh the same amount of polylactic acid fine powder and tertiary acid polylactic acid fine powder, and conduct differential calorimetry scanning from room temperature to 650°C respectively. It can be seen that there are multiple jagged differences in the scanning spectrum of polylactic acid. Thermal peaks, such as 180°C, 267°C, 280°C, 307°C, 407°C, 433°C, 453°C, etc., are mostly small peaks mixed together, showing the molecular characteristics of polymers; scanning of the fine powder of polylactic acid loaded on the bark of Vitex There are obviously four differential thermal peaks in the spectrum, which are 127°C, 280°C, 360°C, and 453°C, respectively, which are sharp peaks, suggesting that Vitex acetic acid may exist in the form of microcrystals in the polylactic acid carrier.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention relates to a preparation method and application of a pseudolaric acid B polylactic acid dispersion. The preparation method of the pseudolaric acid B polylactic acid dispersion includes the steps: polylactic acid is suspended in an organic solvent, pseudolaric acid B is added and dissolved, the organic solvent is removed, a residue is smashed and sieved, and then the pseudolaric acidB polylactic acid dispersion is obtained. The application of the pseudolaric acid B polylactic acid dispersion means that the pseudolaric acid B polylactic acid dispersion has a specific candida albicans resistance effect, and thus through thermoforming or 3D printing, the pseudolaric acid B polylactic acid dispersion is made into an artificial nail and accordingly can conduct treatment or adjuvant treatment on onychomycosis caused by candida albicans.

Description

technical field [0001] The invention relates to a preparation method and application of a drug dispersion, in particular to a preparation method and application of a polylactic acid dispersion of Vitex bark acetic acid. Background technique [0002] Soil wattle bark, also known as soil hibiscus bark, is the dry root bark or near-root bark of the unique Pinaceae plant Pinus chinensis in my country. Vitex acetic acid is a compound with a diterpene acid structure isolated from Vitex bark. It is the main antibacterial component in Vitex bark and has a significant bactericidal effect on Candida albicans (Chinese Hospital Drug Evaluation and Analysis, 2015 Volume 15, Issue 10). Candida albicans is one of the common pathogens causing tinea unguium (commonly known as onychomycosis) (Journal of Traditional Chinese Medicine, 2004 Volume 22, No. 4), Tujingpi is a commonly used traditional Chinese medicine for treating tinea unguium. Jingpi preparations include compound soil hibiscus ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/14A61K31/366A61K47/34A61L27/44A61L27/54A61L27/58A61P17/00A61P31/02A61P31/10
CPCA61K9/0014A61K9/146A61K31/366A61K2236/333A61L27/44A61L27/54A61L27/58A61L2300/216A61L2300/404A61L2300/604A61P17/00A61P31/02A61P31/10C08L67/04
Inventor 国大亮张秀君
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com