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Compound traditional Chinese medicine preparation for preventing and treating Alzheimer's disease and preparation method thereof

A technology of Alzheimer's disease and compound traditional Chinese medicine, which is applied in the field of medicine, can solve the problems of inability to delay the development of the disease, high price, etc., and achieve the effect of less toxic side effects, low price, and improvement of AD symptoms

Active Publication Date: 2020-03-31
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the drugs for the treatment of Alzheimer's disease are mainly acetylcholinesterase inhibitors, anti-immune inflammation, calcium ion antagonists, antioxidants and other drugs. Nimodipine, memantine hydrochloride, etc. These drugs can only temporarily relieve the cognitive decline of patients, but cannot delay the development of the disease. Moreover, some of the above drugs have serious adverse reactions such as liver and kidney toxicity, and some drugs are expensive. It is unbearable, so it is still necessary to develop new drugs with good curative effect, low toxicity and side effects, and affordable prices; It has become a research hotspot to formulate traditional Chinese medicine formulas with reasonable formulas and definite curative effects, and to prepare high-efficiency and low-toxicity traditional Chinese medicine compound preparations for the prevention and treatment of Alzheimer's disease through modern Chinese medicine extraction technology.

Method used

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  • Compound traditional Chinese medicine preparation for preventing and treating Alzheimer's disease and preparation method thereof
  • Compound traditional Chinese medicine preparation for preventing and treating Alzheimer's disease and preparation method thereof
  • Compound traditional Chinese medicine preparation for preventing and treating Alzheimer's disease and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0051] A compound traditional Chinese medicine preparation for preventing and treating Alzheimer's disease comprises:

[0052] Eucommia: 70g;

[0053] Cinnamon: 80g;

[0054] Eclipta: 80g;

[0055] Epimedium: 90g;

[0056] Danpi: 80g;

[0057] Habitat: 60g;

[0058] Ginseng: 50g;

[0059] Schisandra: 80g.

[0060] The preparation method of the compound Chinese medicinal preparation for preventing and treating Alzheimer's disease comprises steps:

[0061] (1) Eucommia ulmoides, cinnamon, eclipta, epimedium, paeonol, habitat, root ginseng, Schisandra chinensis are prepared in various parts by weight;

[0062] (2) Mix eucommia ulmoides, cinnamon and eclipta, pulverize to obtain mixture A, add methanol equivalent to 6 times the weight of the mixture, soak for 5 hours, extract by reflux for 6 hours, filter, and the obtained medicinal residues I and filtrate II are set aside;

[0063] (3) Add 2 times the weight of β-cyclodextrin to the filtrate II obtained in step (2), wrap ...

Embodiment 2

[0067] A compound traditional Chinese medicine preparation for preventing and treating Alzheimer's disease comprises:

[0068] Eucommia: 80g;

[0069] Cinnamon: 100g;

[0070] Eclipta: 100g;

[0071] Epimedium: 110g;

[0072] Danpi: 90g;

[0073] Habitat: 90g;

[0074] Ginseng: 100g;

[0075] Schisandra: 120g.

[0076] The preparation method of the compound Chinese medicinal preparation for preventing and treating Alzheimer's disease comprises steps:

[0077] (1) Eucommia ulmoides, cinnamon, eclipta, epimedium, paeonol, habitat, root ginseng, Schisandra chinensis are prepared in various parts by weight;

[0078] (2) Mix eucommia ulmoides, cinnamon, and Eclipta chinensis, pulverize to obtain mixture A, add methanol equivalent to 8 times the weight of the mixture, soak for 6 hours, extract by reflux for 7 hours, filter, and the obtained medicinal residues I and filtrate II are set aside;

[0079] (3) Add 4 times the weight of β-cyclodextrin to the filtrate II obtained in...

Embodiment 3

[0083] A compound traditional Chinese medicine preparation for preventing and treating Alzheimer's disease comprises:

[0084] Eucommia: 100g;

[0085] Cinnamon: 110g;

[0086] Eclipta: 110g;

[0087] Epimedium: 120g;

[0088] Danpi: 100g;

[0089] Habitat: 110g;

[0090] Ginseng: 120g;

[0091] Schisandra: 130g.

[0092] The preparation method of the compound Chinese medicinal preparation for preventing and treating Alzheimer's disease comprises steps:

[0093] (1) Eucommia ulmoides, cinnamon, eclipta, epimedium, paeonol, habitat, root ginseng, Schisandra chinensis are prepared in various parts by weight;

[0094] (2) Mix eucommia ulmoides, cinnamon and eclipta, pulverize to obtain mixture A, add methanol equivalent to 12 times the weight of the mixture, soak for 7 hours, extract by reflux for 8 hours, filter, and the obtained medicinal residues I and filtrate II are set aside;

[0095] (3) Add 5 times the weight of β-cyclodextrin to the filtrate II obtained in step (...

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Abstract

The invention discloses a compound traditional Chinese medicine preparation for preventing and treating the Alzheimer's disease and a preparation method thereof. The compound traditional Chinese medicine preparation comprises the following components, by weight: 50 to 250 parts of the bark of eucommia, 60 to 180 parts of cassia bark, 60 to 250 parts of herba ecliptae, 70 to 300 parts of epimediumherb, 60 to 200 parts of the root bark of the peony tree, 60 to 180 parts of the dried rhizome of rehmannia, 50 to 200 parts of radix scrophulariae, and 80 to 160 parts of the fruit of Chinese magnoliavine. According to the invention, the compound traditional Chinese medicine preparation can effectively tonify kidney and qi, promote blood circulation to remove toxin, effectively relieve neuroinflammatory reaction and improve AD symptoms and is suitable for preventing and treating AD and related diseases. The compound traditional Chinese medicine preparation is good in curative effect, small intoxic and side effect, and low in price and is suitable for wide clinical popularization.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound traditional Chinese medicine preparation for preventing and treating Alzheimer's disease and a preparation method thereof. Background technique [0002] Alzheimer's Disease (AD) is the most common neurodegenerative disease, and it is also the main cause of senile dementia so far. Among all dementia patients, up to 50% to 60% are AD. AD is the fourth leading cause of death in the elderly after heart disease, cancer, and stroke. Because the pathological mechanism of AD is very complicated, the etiology is not very clear at present, and there is also a lack of effective treatment measures. Therefore, actively studying the pathogenesis of AD and developing effective anti-AD drugs is one of the important tasks in the field of senile disease research. [0003] From the point of view of traditional Chinese medicine in my country, cognitive impairment and senile dementia belong to th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/808A61K47/69A61P25/28
CPCA61K36/28A61K36/296A61K36/46A61K36/54A61K36/57A61K36/65A61K36/71A61K36/79A61K36/804A61K36/808A61K2236/33A61K47/6951A61P25/28A61K2300/00
Inventor 吴海强李玥余熙谢亚洲欧阳娜贺震旦刘志刚吴序栎刘立忠
Owner SHENZHEN UNIV
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