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Pharmaceutical composition for treating dermatomycosis infection and preparation process thereof

A technology for dermatophytes and antifungal drugs, applied in the field of medicinal chemistry, can solve the problems of less adhesion of active ingredients, toxic and side effects or irritation, and easy recurrence, and achieve the advantages of simple and easy preparation process, convenient and safe use, and remarkable clinical curative effect Effect

Inactive Publication Date: 2020-03-24
ZHUOHE PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the oral preparations, pure western medicine preparations account for a large proportion, and there are few traditional Chinese medicine preparations. After years of clinical application, the shortcomings of western medicine preparations have gradually emerged. The curative effect is not ideal, and drug withdrawal is easy to relapse. irritant
External preparations mainly focus on liniments, liniments, tinctures, and patches based on compound Chinese medicines, supplemented by steroid hormones in combination, but multiple medications lead to poor compliance of patients with medication, and tinctures and patches are easily affected by the external environment when used , the active ingredient is less attached, resulting in the local drug not reaching the effective concentration or the effective maintenance time is too short, and the transdermal absorption effect is not good

Method used

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  • Pharmaceutical composition for treating dermatomycosis infection and preparation process thereof
  • Pharmaceutical composition for treating dermatomycosis infection and preparation process thereof
  • Pharmaceutical composition for treating dermatomycosis infection and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] This embodiment discloses a pharmaceutical composition for treating fungal skin infections, which comprises the following components: azole antifungal drugs, Sophora flavescens, Fructus Cnidii, mustard ear, Angelica dahurica, Forsythia atractylodes, Atractylodes atractylodes, Clematis, Smilax tuckahoe , Dafengzi, gallnut, white fresh skin, cork, rhubarb, accessories.

[0024] The azole antifungal drug is posaconazole. The auxiliary material is a mixture of a penetration enhancer, a solvent, a moisturizing agent, an aqueous base, an emulsifier, and an antioxidant. The penetration enhancer is a mixture of azone and menthol; the solvent is water; the humectant is a mixture of glycerin and propylene glycol; the aqueous base is carbomer; the emulsifier is triethanolamine; Antioxidant is sodium bisulfite.

[0025] The weight of each component of this pharmaceutical composition is as follows:

[0026] Element Dosage posaconazole 0.1g Sophora flavescens...

Embodiment 2

[0033] This embodiment discloses a pharmaceutical composition for treating fungal skin infections, which comprises the following components: azole antifungal drugs, Sophora flavescens, Fructus Cnidii, mustard ear, Angelica dahurica, Forsythia atractylodes, Atractylodes atractylodes, Clematis, Smilax tuckahoe , Dafengzi, gallnut, white fresh skin, cork, rhubarb, accessories.

[0034] The azole antifungal drug is posaconazole. The auxiliary material is a mixture of a penetration enhancer, a solvent, a moisturizing agent, an aqueous base, an emulsifier, and an antioxidant. The penetration enhancer is a mixture of azone and menthol; the solvent is water; the humectant is a mixture of glycerin and propylene glycol; the aqueous base is carbomer; the emulsifier is triethanolamine; Antioxidant is sodium bisulfite.

[0035] The weight of each component of this pharmaceutical composition is as follows:

[0036]

[0037]

[0038] This embodiment also discloses a preparation proc...

Embodiment 3

[0044] This embodiment discloses a pharmaceutical composition for treating fungal skin infections, which comprises the following components: azole antifungal drugs, Sophora flavescens, Fructus Cnidii, mustard ear, Angelica dahurica, Forsythia atractylodes, Atractylodes atractylodes, Clematis, Smilax tuckahoe , Dafengzi, gallnut, white fresh skin, cork, rhubarb, accessories.

[0045] The azole antifungal drug is voriconazole. The auxiliary material is a mixture of penetration enhancer, solvent, moisturizing agent and preservative. The penetration enhancer is a mixture of Tween 80 and menthol; the solvent is water; the moisturizing agent is propylene glycol; and the preservative is sodium benzoate.

[0046] The weight of each component of this pharmaceutical composition is as follows:

[0047]

[0048]

[0049]This embodiment also discloses a preparation process of a pharmaceutical composition for treating fungal skin infections, comprising the following steps:

[0050]...

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Abstract

The invention provides a pharmaceutical composition for treating dermatomycosis infection. The pharmaceutical composition is prepared from the components: azole antifungal drugs, radix sophorae flavescentis, fructus cnidii, spikes of Chinese mustard, radix angelicae dahuricae, fructus forsythiae, rhizoma atractylodis, radix clematidis, rhizoma smilacis glabrae, chaulmoogra, gallnut, cortex dictamni, cortex phellodendri, rheum officinale and auxiliary materials. The invention provides the pharmaceutical composition for treating dermatomycosis infection and a preparation process thereof. By adopting the theory of combination of traditional Chinese medicine and western medicine, the selected western medicine has an antifungal effect, and the selected traditional Chinese medicines have the effects of clearing heat and drying dampness. The pharmaceutical composition can treat both symptoms and root causes, has the advantages of wide treatment range, remarkable clinical effect, small toxic and side effects, convenient and safe use, simple and feasible preparation process, low cost and remarkable clinical application effect, and is suitable for wide popularization.

Description

technical field [0001] The invention relates to the technical field of medicinal chemistry, in particular to a pharmaceutical composition for treating skin fungus infection and a preparation process thereof. Background technique [0002] Skin fungal infection is very common in the world at present, mainly caused by ringworm fungus invading the skin, hair, nail (toe) and other body surface parts. After infecting the human body, it can cause tissue reactions and produce erythema papules, blisters, scales, broken skin, etc. Hair loss, hair loss, and deck changes, etc. [0003] At present, the treatment of skin fungal infection mainly includes systemic treatment with oral antimicrobials, topical treatment with topical drugs or a combination of both. Among the oral preparations, pure western medicine preparations account for a large proportion, and there are few traditional Chinese medicine preparations. After years of clinical application, the shortcomings of western medicine p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K36/90A61P17/00A61P31/10A61K31/496A61K31/506A61K35/64
CPCA61K31/496A61K31/506A61K35/64A61K36/185A61K36/232A61K36/234A61K36/284A61K36/489A61K36/538A61K36/634A61K36/708A61K36/716A61K36/75A61K36/756A61K36/896A61K36/90A61P17/00A61P31/10A61K2300/00
Inventor 薛丹露朱丽
Owner ZHUOHE PHARM GRP CO LTD
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