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Hydrogel base material and preparation method thereof, and applications of hydrogel base material in the biomedical field

A hydrogel and base material technology, which is applied in the field of hydrogel base material and its preparation, can solve the problems of weak adhesion and difficulty in storage, and achieve the effects of easy detachment, low water loss and fast adhesion

Active Publication Date: 2020-02-28
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hydrogel substrate overcomes the problems of weak adhesion and difficult preservation of traditional hydrogels, and through structural design, hydrogel substrates with different mechanical behaviors and adhesion can be prepared, which can match different tissue structures for adhesion force requirements

Method used

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  • Hydrogel base material and preparation method thereof, and applications of hydrogel base material in the biomedical field
  • Hydrogel base material and preparation method thereof, and applications of hydrogel base material in the biomedical field
  • Hydrogel base material and preparation method thereof, and applications of hydrogel base material in the biomedical field

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] 12gN, N-dimethylacrylamide, 40mgN, N'-methylenebisacrylamide, 48g water, 12g glycerol, 12g polyacrylic acid (M w =5000) and 50 mg of ammonium persulfate were uniformly mixed, and reacted for 24 hours in an inert gas atmosphere and at 70° C. to obtain a biomedical hydrogel substrate.

[0048] Aluminum panels were used to test the adhesion of the hydrogel substrates. The bonding strength of the hydrogel substrate on the aluminum plate measured by the universal material testing machine is 56±8kPa.

[0049] Make a strip-shaped substrate in a specific mold and test its mechanical behavior on a universal material testing machine. The compression modulus is 2.0±0.2kPa, and the compression deformation can reach 70% (see figure 1 ). Its tensile modulus is 11.1±2.0kPa, and the elongation rate reaches 5 times (see figure 2 ).

Embodiment 2

[0051] 12g acrylamide, 20mgN, N'-methylenebisacrylamide, 48g water, 12g glycerol, 12g polyacrylic acid (M w =5000) and 50 mg of ammonium persulfate were uniformly mixed, and reacted for 24 hours in an inert gas atmosphere and at 70° C. to obtain a biomedical hydrogel substrate.

[0052] The adhesion of the substrates is tested with aluminum, iron and glass plates. It is 73 ± 4kPa that this hydrogel base material is measured on the universal material testing machine on the aluminum plate, and the bond strength on the iron plate is 83 ± 3kPa, and the bond strength on the glass is 96 ± 3kPa (see image 3 Middle AG-1).

[0053] Make a strip-shaped substrate in a specific mold and test its mechanical behavior on a universal material testing machine. The compression modulus is 3.8±0.5kPa, and the compression deformation can reach 90% (see Figure 4 Middle AG-1). Its tensile modulus is 11.1±0.4kPa, and the elongation rate reaches 10.5 times (see Figure 5 Middle AG-1).

Embodiment 3

[0055] 12g acrylamide, 30mgN, N'-methylenebisacrylamide, 48g water, 12g glycerol, 12g polyacrylic acid (M w =5000) and 50 mg of ammonium persulfate were uniformly mixed, and reacted for 24 hours in an inert gas atmosphere and at 70° C. to obtain a biomedical hydrogel substrate.

[0056] The adhesion of the substrates is tested with aluminum, iron and glass plates. It is 72 ± 3kPa that this hydrogel base material is measured on the universal material testing machine on the aluminum plate, and the bond strength on the iron plate is 82 ± 5kPa, and the bond strength on the glass is 83 ± 9kPa (see image 3 Middle AG-2).

[0057] Make a strip-shaped base material in a specific mold and test its mechanical behavior on a universal material testing machine. Its compression modulus is 4.9 ± 0.3kPa, and its compression deformation can reach 90% (see Figure 4 Middle AG-2). Its tensile modulus is 20.1±0.7kPa, and the elongation rate reaches 7 times (see Figure 5 Middle AG-2).

[005...

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Abstract

The invention belongs to the technical field of biomedical materials, and particularly relates to a hydrogel base material and a preparation method thereof, and applications of the hydrogel base material in the biomedical field. According to the invention, the hydrogel base material overcomes the problems of poor adhesive force, difficult storage and the like of the traditional base material; thehydrogel base materials with different mechanical behaviors and different adhesive force can be prepared by changing the components and the structure of the gel so as to meet the requirements of different wounds on the adhesive force of base materials; the adhesion speed of the hydrogel base material is high, the wound healing condition can be directly observed through the transparent base material, and the base material can be mildly separated from a wound through water so as not to cause secondary damage to the wound; water-retaining agent micromolecules are introduced into the hydrogel basematerial; compared with the traditional base material, the hydrogel base material of the invention is easy to store, and less occurs the adhesive force reducing caused by water loss under the external use condition; and the hydrogel base material is simple in process and easy to produce, and has wide application prospects in the fields of common trauma, diabetic ulcer and the like.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a hydrogel substrate, a preparation method thereof and an application in the biomedical field. Background technique [0002] A hydrogel is a flexible material rich in water. Because it is very close to natural tissue, it has been widely used in the fields of biomedicine, tissue engineering and regenerative medicine. For example, inspired by the structure of shrimp shells and the mineralization process in organisms, a biocompatible hydrogel sensor with high sensitivity has been prepared by using polymer materials; The characteristics of hydrogels can be widely used as drug sustained-release materials; the use of hydrogels can provide moisture, promote wound healing, remove necrotic tissue, and high water content gels can reduce wound temperature and relieve pain. Glue can be used as a wound dressing. The above applications require hydrogel materials to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L51/00C08F265/02C08F220/54C08F220/56C08F220/06C08F212/14C08F222/38C08F2/48A61K9/06A61K47/32A61L26/00
CPCA61K9/06A61K47/32A61L26/0014A61L26/008C08F2/48C08F222/385C08F265/02C08J3/075C08J2351/00C08F220/54C08F220/56C08F212/14C08F220/06
Inventor 邱东王晨
Owner INST OF CHEM CHINESE ACAD OF SCI
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