Micro-expanded and self-solidified bone repair material containing hydrogen and trace elements, and preparation method thereof

A technology for bone repair and water content, applied in pharmaceutical formulations, medical science, tissue regeneration, etc., can solve the problems of loosening, reduce the effect of material repair, and single function, and achieve the effect of avoiding voids and loosening, and improving regeneration and reconstruction functions.

Pending Publication Date: 2020-02-28
中鼎凯瑞科技成都有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The main problems of these self-solidifying materials are: 1. The composition is single and the function is single; 2. The degradation speed does not match the bone reconstruction speed; 3. The shrinkage after solidification, sometimes reaching more than 20%, resulting in the inability to closely contact with the wound. Loosening, reducing the repair effect of the material, or even failure

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Weigh 200g of calcium glycerophosphate, 300g of calcium citrate, 450g of calcium sulfate hemihydrate, and 50g of strontium sulfate hemihydrate, mix them, ball mill them at room temperature for 6 hours, pass through a 100-mesh sieve, and pass through all of them. It was then vacuum-dried at 80 degrees for 8 hours; 20 g of calcium hydride (CaH 2 ) was added to 50ml of anhydrous ether, ground for 5 minutes under the protection of dry high-purity nitrogen, and then the ether was removed by hot nitrogen; calcium hydride was mixed with the above-mentioned dried calcium glycerophosphate, calcium citrate, and calcium sulfate mixed powder , under the protection of dry nitrogen, grind for 5 minutes to obtain a bone repair material.

[0039] Get this material of 100g, add 50ml water for injection, stir 2 minutes, put into syringe outlet internal diameter 5mm, extrude by syringe; Measure its diameter after 20 minutes, and compare with syringe internal diameter; And measure its coag...

Embodiment 2

[0046] Weigh 300g glycerophosphate (200g calcium glycerophosphate, 100g calcium magnesium glycerophosphate), 300g calcium citrate, 350g calcium sulfate hemihydrate, 50g strontium sulfate hemihydrate, mix, ball mill at room temperature for 6 hours, pass through 100 mesh sieve, all drained; then it was vacuum-dried at 80°C for 8 hours. Add 10g of lithium hydride (LiH) to 30ml of anhydrous ether, grind for 5 minutes under the protection of dry high-purity nitrogen, and then remove the ether by hot nitrogen; mix lithium hydride with the above-mentioned dried glycerophosphate, calcium citrate , Sulfate mixed powder mixed, under the protection of dry nitrogen, ground for 5 minutes to obtain the solidified bone repair material.

[0047] The application process and performance test process of the bone repair material are the same as Example 1, the only difference is that the solid-liquid ratio (water:solid) is 0.6:1.

[0048] The test results are as follows: 1) Measure its diameter a...

Embodiment 3

[0050] Take by weighing 300g calcium glycerophosphate, 300g citrate (100g magnesium citrate, 100g calcium citrate, 50g zinc citrate, 50g strontium citrate), 400g calcium sulfate hemihydrate, mix, ball mill at normal temperature for 6 hours, after Sieve through a 100-mesh sieve and pass through; then vacuum-dry it at 80 degrees for 8 hours. Take 10g calcium hydride (CaH 2 ) was added to 50ml of anhydrous ether, ground for 5 minutes under the protection of dry high-purity nitrogen, and then the ether was removed by hot nitrogen; the calcium hydride was mixed with the above-mentioned dried calcium glycerophosphate, citrate, and calcium sulfate mixed powder , under the protection of dry nitrogen, grind for 5 minutes to obtain the solidified bone repair material.

[0051] The application process and performance test process of the bone repair material are the same as Example 1, the only difference is that the solid-liquid ratio (water:solid) is 0.6:1.

[0052] The test results ar...

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Abstract

The invention belongs to the field of bone repair materials, particularly relates to a micro-expanded and self-solidified composite bone implant containing hydrogen and trace elements, and a preparation method thereof, and provides a self-solidified bone repair material. The self-solidified bone repair material comprises a metal hydride capable of releasing the hydrogen when contacting water, anda self-solidified substance, wherein the mass ratio of the metal hydride to the self-solidified substance is (0.5-19.5):(99.5-81.5). The micro-expanded and self-solidified composite bone implant containing the hydrogen and the trace elements is prepared from the hydride capable of releasing the nitrogen when contacting the water, and the self-solidified substance; the composite implant has a micro-expansion function, volume expansion (0.1-20%) of the self-solidified composite bone implant can be achieved in a hydrogen production process, and the self-solidified composite bone implant can be tightly combined with tissue interfaces to avoid gaps and looseness both caused by volume shrinkage.

Description

technical field [0001] The invention belongs to the field of bone repair materials, in particular to a micro-expanded self-solidifying composite bone implant containing hydrogen and trace elements and a preparation method thereof. Background technique [0002] Bone tissue is the basic system that supports and maintains the normal physiological functions of the human body. Due to the necrosis, damage and loss of function of bone tissue due to various factors such as diseases, hypoplasia, car accidents and aging, a large number of biomaterials are needed as bone tissue repair and replacement. Bone tissue is the basic system that supports and maintains the normal physiological functions of the human body. Due to the necrosis, damage and loss of function of bone tissue due to various factors such as diseases, hypoplasia, car accidents and aging, a large number of biomaterials are needed as bone tissue repair and replacement. Bone tissue is the basic system that supports and main...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/02A61L27/00A61L27/50
CPCA61L27/00A61L27/025A61L27/50A61L2400/06A61L2430/02
Inventor 严永刚邓光进严大卫戢觅之
Owner 中鼎凯瑞科技成都有限公司
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