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A method for preparing porous polymer microneedles and its application

A porous polymer, polymer technology, applied in microneedles, pharmaceutical devices, inactive components of polymer compounds, etc., can solve the complex preparation process of porous polymer microneedles, difficulties in large-scale production and application, size and distribution Difficult to control and other problems, to achieve the effects of good pore size and distribution controllability, high drug loading, and low cost

Active Publication Date: 2021-05-18
HUAZHONG UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above defects or improvement needs of the prior art, the object of the present invention is to provide a method for preparing porous polymer microneedles and its application, wherein the overall process design of the preparation method and key freeze-drying technical steps The related conditions and parameters (such as the pressure during freeze-drying) are improved, which can effectively adjust the properties such as the pore structure, size and distribution of the prepared porous polymer microneedles; Porous polymer microneedles can be prepared on a large scale, which can solve the complex preparation process of porous polymer microneedles, harsh conditions, cumbersome processes, high prices, difficult control of pore structure, size and distribution, and difficulties in large-scale production and application. question

Method used

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  • A method for preparing porous polymer microneedles and its application
  • A method for preparing porous polymer microneedles and its application
  • A method for preparing porous polymer microneedles and its application

Examples

Experimental program
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Effect test

Embodiment 1

[0035] A porous polymer microneedle array prepared by freeze-drying technology is prepared according to the following method: first, a PDMS (polydimethylsiloxane) negative mold is prepared by a micro-template method, and the negative mold is placed in dimethyl sulfoxide Take it out after immersing in the medium for 2 hours, remove the excess dimethyl sulfoxide on the surface of the female mold; then, drop the dimethyl sulfoxide solution of cellulose acetate with a molecular weight of 10kDa and a mass fraction of 30% onto the female mold, and place In a beaker with dimethyl sulfoxide, after ultrasonication for 1 hour, freeze in the refrigerator and place in a freeze dryer at 25°C, 10 -9 freeze-drying under Pa, and demoulding to obtain porous cellulose acetate microneedles.

[0036] The porous cellulose acetate microneedles obtained in this example have a pore size of 10 nm.

[0037] The parameters, conditions, etc. used in Embodiment 2 to Embodiment 14 are shown in the followi...

Embodiment 15

[0042] Example 15 Simulate the experiment of absorbing interstitial fluid

[0043] Porous cellulose acetate (CA) microneedles were prepared by the method of Example 1, inserted into a pre-prepared 3% agar hydrogel containing 1 mg / mL rhodamine B, and observed under a microscope.

[0044] Under the microscope, it can be clearly seen that the needle tip of the porous cellulose acetate microneedle is white before being inserted into the agar gel, and turns red after being inserted. The red color is the color of the model molecule rhodamine B, indicating that the porous polymer microneedle can absorb the model drug molecular.

Embodiment 16

[0045] Embodiment 16 animal skin experiment

[0046] Porous cellulose acetate (CA) microneedles were prepared using the method of Example 1, and rhodamine B was loaded in the porous microneedles, which were inserted into the flat fresh mouse skin that had been depilated in advance, and after a period of time Mouse skin was observed under a fluorescent microscope.

[0047] It was observed under an optical microscope that there were obvious holes on the surface of the treated mouse skin, and the rest of the skin was intact, indicating that the porous polymer microneedles could effectively pierce the mouse epidermis. Similarly, it can be observed under the fluorescence microscope that the surface of the mouse skin after the treatment has obvious green fluorescence, and other parts are black, indicating that the green fluorescence is caused by the rhodamine B remaining in the microneedle after the porous polymer microneedle pierces the skin. The hole formed at the lower part of t...

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Abstract

The invention discloses a method for preparing a porous polymer microneedle and its application, wherein the preparation method includes the following steps: (1) dissolving the polymer in a solvent to obtain a polymer solution; (2) filling the polymer solution into the microneedle (3) freeze the microneedle mold filled with polymer solution as a whole; (4) remove the solvent contained in the frozen microneedles by freeze-drying, and then demould to obtain porous polymer microneedles ; Wherein, the freeze-drying process is carried out under the condition that the pressure is 0-100Pa. The present invention can prepare porous polymer microneedles on a large scale through a simple and mild freeze-drying technique, thereby solving the problem of complex preparation process, harsh conditions, cumbersome process, high price, and difficulty in controlling the pore structure, size and distribution of porous polymer microneedles. As well as technical problems such as large-scale production and application difficulties; the prepared porous polymer microneedles can be used for interstitial fluid extraction and transdermal drug delivery.

Description

technical field [0001] The invention belongs to the field of biomedical polymer materials, and more specifically relates to a method for preparing porous polymer microneedles and its application. The preparation method uses freeze-drying technology to prepare porous polymer microneedles, and is especially suitable for preparing porous polymer The material microneedle array, the prepared porous polymer microneedle can be applied to the preparation of preparations for extracting skin tissue fluid or blood or the preparation of pharmaceutical preparations for transdermal administration. Background technique [0002] Microneedles are three-dimensional array structures made of silicon, metal, and polymers with a length of 25–2000 μm and tapered tips. Microneedle is a new type of minimally invasive drug delivery tool in the field of biomedicine, which can enhance the effect of skin drug delivery through the epidermis and dermis of the skin. In recent years, microneedles have attr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K47/32A61K47/34A61K47/38A61K47/10A61K47/36A61K47/42A61K35/14A61P17/00A61P17/18A61P3/10A61P17/06A61P17/14A61P35/00A61M37/00
CPCA61K9/0021A61K35/14A61K47/10A61K47/32A61K47/34A61K47/36A61K47/38A61K47/42A61M37/0015A61M2037/0053A61M2037/0061A61P3/10A61P17/00A61P17/06A61P17/14A61P17/18A61P35/00
Inventor 朱锦涛柳佩田迪王华张连斌杜虹瑶陶娟李钰策
Owner HUAZHONG UNIV OF SCI & TECH
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