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Flavonoid glycoside adsorption resin and preparation method thereof

A technology for adsorbing resin and flavonoid glycosides, applied in chemical instruments and methods, other chemical processes, alkali metal oxides/hydroxides, etc., can solve the problems of complex separation operation process, low separation efficiency, poor specificity, etc. The operation process is simple, the separation efficiency is high, and the elution is easy.

Active Publication Date: 2020-02-25
ZHONGBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the method of separating flavonoid glycosides from plants mainly uses silica gel or macroporous resin as adsorption materials, and separates them through van der Waals force or hydrogen bonds. However, the existing adsorption materials generally have poor specificity, low separation efficiency, and high adsorption capacity. There are few problems, and it is difficult to elute, and the separation operation process is complicated, so it is limited in large-scale industrial production applications

Method used

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  • Flavonoid glycoside adsorption resin and preparation method thereof
  • Flavonoid glycoside adsorption resin and preparation method thereof
  • Flavonoid glycoside adsorption resin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The macroporous resin D941 with primary amino groups is used as the matrix.

[0034] Step 1: Pretreatment of macroporous resin D941

[0035] Soak the macroporous resin D941 in deionized water overnight, then wash it repeatedly with distilled water, and finally filter it with suction and dry it for later use.

[0036] Step 2: Grafting organic long-chain polymers on the surface of macroporous resin D941

[0037] Glycidyl methacrylate (GMA) is used as a functional monomer to graft an organic long-chain polymer on the surface of the macroporous resin D941 through a free radical chain reaction to obtain the grafted material pGMA / D941, specifically:

[0038] Put 1g of pretreated macroporous resin D941, 100mL of N,N-dimethylformamide (DMF) and 15mL of functional monomer GMA into a 250mL four-necked flask, and use N 2 Empty the air in the four-necked flask, then raise the temperature of the water bath to 60°C, add 0.10g of initiator ammonium persulfate, and carry out graft po...

Embodiment 2

[0045] The macroporous resin D315 with primary amino groups is used as the matrix.

[0046] Step 1: Pretreatment of macroporous resin D315

[0047] Soak the macroporous resin D315 in deionized water overnight, then wash it repeatedly with distilled water, and finally filter it with suction and dry it for later use.

[0048] Step 2: Grafting organic long-chain polymers on the surface of macroporous resin D315

[0049] Using GMA as a functional monomer, graft organic long-chain polymers on the surface of macroporous resin D315 through free radical chain reaction to obtain grafted material pGMA / D315, specifically:

[0050] Put 1g of pretreated macroporous resin D315, 100mL DMF and 15mL functional monomer GMA into a 250mL four-necked flask, and use N 2Evacuate the air in the four-necked flask, then raise the temperature of the water bath to 50°C, add 0.15g of initiator ammonium persulfate, and carry out graft polymerization reaction under constant temperature and stirring condit...

Embodiment 3

[0058] The macroporous resin D315 with primary amino groups is used as the matrix.

[0059] Step 1: Pretreatment of macroporous resin D315

[0060] The same method as that of Embodiment 2 is adopted, and details are not repeated here.

[0061] Step 2: Grafting organic long-chain polymers on the surface of macroporous resin D315

[0062] Put 1g of pretreated macroporous resin D315, 100mL DMF and 20mL functional monomer GMA into a 250mL four-necked flask, and use N 2 Empty the air in the four-necked flask, then raise the temperature of the water bath to 55°C, add 0.20g of initiator ammonium persulfate, and carry out graft polymerization reaction under constant temperature and stirring conditions, the reaction time is 18h, and then suction filtration, The filter cake was washed with absolute ethanol to remove the polymer physically adsorbed on the surface of the microspheres to obtain the grafted material pGMA / D315, dried in vacuum and set aside.

[0063] Step 3: Incorporation...

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Abstract

The invention discloses a flavonoid glycoside adsorption resin and a preparation method thereof. The flavonoid glycoside adsorption resin is prepared through using macro-porous resin as a matrix and adopting a technology firstly adopting graft polymerization and then epoxy ring opening. The method is specifically characterized in that glycidyl methacrylate is used as a functional monomer, the surface of the macro-porous resin is grafted with an organic long-chain polymer through a free radical chain reaction, 3-aminophenylboronic acid is used as a ring-opening reaction substance, and a boric acid group is introduced into the chain segment of the organic long-chain polymer through an epoxy ring-opening reaction. The flavonoid adsorption resin has the following advantages: (1) the flavonoidadsorption resin has high specificity, can be used to effectively separate flavonoid glycosides from natural plants, the separation efficiency is high, and the adsorption capacity is large; and (2) the elution is very easy and convenient, the eluted resin does can be directly used for the next flavonoid glycoside adsorption without being regenerated and preprocessed, and the operation process is very simple and convenient.

Description

technical field [0001] The invention relates to an adsorption resin and a preparation method thereof, in particular to a flavonoid glycoside adsorption resin and a preparation method thereof, and belongs to the technical field of adsorption and separation. Background technique [0002] Flavonoids (Flavonoids) are a class of widely distributed and important natural polyphenolic products in plants, also known as plant flavonoids or bioflavonoids. The existing forms of flavonoids in plants can be mainly divided into two forms: free state and bound glycosides, and most flavonoids exist in the form of bound glycosides. As the most common glycoside form of flavonoids, flavonoid glycosides have important biological activities such as scavenging free radicals, anti-oxidation, anti-cancer, anti-inflammatory, anti-bacterial, regulating blood lipids, and regulating immunity. They have been widely used in medicine, cosmetics, and food. . [0003] At present, the method of separating f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/36C08J9/40C08L101/02B01J20/26B01J20/28B01J20/30
CPCC08J9/36C08J9/40B01J20/265B01J20/28054C08J2300/106C08J2433/14
Inventor 史楠王海宾李紫玉高莉郭建峰王芳严文霞洪雅茹杨芬芳
Owner ZHONGBEI UNIV
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