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pH-responsive biodegradable high-strength hydrogel and preparation method thereof, and applications in stomach filling agents

A hydrogel, high-strength technology, applied in the field of smart hydrogel preparation, can solve the problem of non-degradability of PVDT hydrogel, and achieve the effect of broadening the scope of application and broad application prospects.

Inactive Publication Date: 2020-02-25
TIANJIN UNIV
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  • Abstract
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  • Application Information

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Problems solved by technology

However, these PVDT hydrogels are non-degradable due to the introduction of stable chemical cross-links

Method used

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  • pH-responsive biodegradable high-strength hydrogel and preparation method thereof, and applications in stomach filling agents
  • pH-responsive biodegradable high-strength hydrogel and preparation method thereof, and applications in stomach filling agents
  • pH-responsive biodegradable high-strength hydrogel and preparation method thereof, and applications in stomach filling agents

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Embodiment Construction

[0019] The technical solutions of the present invention will be further described below in conjunction with specific embodiments. The present invention selects gelatin, 2-vinyl-4,6-diamino-1,3,5-triazine, 2,4-diamino-6-vinyltriazine, methyl Acrylic anhydride and photoinitiator are IRGACURE 2959, and the above-mentioned raw materials can be purchased through commercial channels, wherein gelatin is type A, and the reaction reagent type is Vetec TM , V900863-500G, made from pigskin.

[0020] Preparation of methacrylated gelatin: fully dissolve gelatin in deionized water in a water bath at 40°C. Then add N,N-dimethylformamide (DMF) with a solvent volume of 2 / 3, add methacrylic anhydride after the solution is clarified, react at 40°C for 2 hours, settle and freeze-dry to obtain methacrylic acid gelatin (GelMA). Gelatin and methacrylated gelatin (GelMA) were characterized by NMR, as attached figure 1 As shown, by comparing the two spectrograms, it is found that there are two obv...

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Abstract

The invention discloses a pH-responsive biodegradable high-strength hydrogel and a preparation method thereof, and applications of the hydrogel in stomach filling agents. According to the invention, gelatin is modified with methacrylic anhydride to obtain methacrylated gelatin, and the copolymerization of 2-vinyl-4,6-diamino-1,3,5-triazine and the methacrylated gelatin is initiated by using UV toprepare the pH-responsive biodegradable high-strength hydrogel PVDT-GelMA; in rabbit model experiments, the PVDT-GelMA hydrogel can stay in the stomach for about 48 h, and the metabolites of the PVDT-GelMA hydrogel are non-toxic, so the PVDT-GelMA hydrogel has huge potential in the fields of gastric filling agents or weight loss intervention, drug delivery and the like; the method is simple to operate and easy to prepare.

Description

technical field [0001] The invention belongs to the field of intelligent hydrogel preparation, and more specifically relates to a pH-responsive, biodegradable high-strength hydrogel, its preparation method and its application in gastric fillers. Background technique [0002] Hydrogel is a three-dimensional network polymer with high water content. As a soft material, hydrogels have been investigated for various biomedical applications due to their soft tissue-like properties. However, the inherently poor mechanical properties of conventional hydrogels limit their practical applications. In the past decade, efforts have been made to design and fabricate high-strength hydrogels, such as nanocomposite hydrogels, double network hydrogels, topological hydrogels, hydrogen bond / dipole-dipole enhanced hydrogels, Chemical / ionically cross-linked hydrogels, etc. Despite exciting achievements, few high-strength hydrogels have been reported to be degradable in physiological microorgani...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08F289/00C08F226/06A61K9/06A61K47/32A61K49/22
CPCA61K9/06A61K47/32A61K49/22C08F289/00C08J3/075C08J2351/00C08F226/06
Inventor 刘文广武腾玲
Owner TIANJIN UNIV
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