A kind of preparation method and application of wound dressing based on breast milk

Abstract

The invention discloses a preparation method and application of a wound dressing based on breast milk. The invention provides a method for preparing a wound dressing based on breast milk, comprising the following steps: S1. after freeze-drying the breast milk, dissolve it in a biocompatible solvent to obtain a breast milk solution; wherein, the concentration of the breast milk solution described in step S1 greater than or equal to 1 μg / mL; S2. filter and sterilize the breast milk solution obtained in step S1 to obtain the wound dressing. The wound dressing has low immunogenicity and will not cause additional inflammatory reactions in the body; it can scavenge hydroxyl free radicals and intracellular reactive oxygen species, increase the proliferation rate of cells, promote the migration of fibroblasts and endothelial cells, and strengthen endothelial Cell angiogenesis; regulates the M2 phenotype of macrophages, promotes hair follicle regeneration, and normalizes wound healing. In addition, the material of the wound dressing is derived from food breast milk, which is green and safe, and the preparation process is simple, so it has broad prospects for popularization and application.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to a preparation method and application of a breast milk-based wound dressing. Background technique [0002] The skin is the largest organ in the human body, and its functions include defense against microorganisms and regulation of body temperature. Therefore, once the skin is injured, it is necessary to accelerate wound healing quickly to avoid further formation of chronic wounds. What's more, skin repair has a considerable drawback, that is, severely damaged skin can heal, but it can't regenerate, and can form scars; the formation of these scars is not only a cosmetic defect, but also prevents the normal functioning of the body. Exercise prevents the body from cooling down due to the lack of sweat glands, resulting in elevated body temperature and metabolic disorders. Although the scar looks thicker than normal skin, its elasticity is actually poorer than n...

AI Technical Summary

Problems solved by technology

[0003] Existing medicines for the treatment of wounds, Western medicine often use medicines with anti-inflammatory, antibacterial and analgesic effects, such as antibiotics, silver salts, etc., mainly anti-inflammatory, analgesic and antibacterial; but due to the large side effects, the promotion of deep wounds Poor skin regeneration ability, unsatisfactory scar repair effect and high price, so its clinical application has certain limitations

Traditional Chinese medicine often uses wound ointments that have anti-inflammatory, muscle-promoting, and heat-toxin-removing effects, such as Jingwanhong, Meiyushang ointment, and Baoshi moist burn ointment, etc.; Or clinical prescriptions, with a long history of use, mainly rely on drug experience, lack of systematic pharmacological research experimental data to demonstrate efficacy

There are also some drugs used to treat scars in the current market, such as hormone drugs, antineoplastic drugs, substance P inhibitors, cytokines and immunosuppressants; but these drugs are expensive, the production process is tedious, the effect is different, and there are certain degree of adverse reaction

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