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Method of pyrolysis and slow release of carbon monoxide by metal carbonyl complex

A technology of carbonyl complexes and carbon monoxide, which is applied in the direction of carbon monoxide, pharmaceutical formulations, drug combinations, etc., can solve the problems of human side effects, heavy metal ions and non-carbonyl ligands that cannot be excluded from the body, and achieve the effect of stable physical properties

Active Publication Date: 2020-01-07
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problem that the heavy metal ions and non-carbonyl ligands produced after the in-situ release of the existing CO-RM cannot be excluded from the body and easily cause side effects on the human body. method

Method used

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  • Method of pyrolysis and slow release of carbon monoxide by metal carbonyl complex
  • Method of pyrolysis and slow release of carbon monoxide by metal carbonyl complex
  • Method of pyrolysis and slow release of carbon monoxide by metal carbonyl complex

Examples

Experimental program
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Effect test

Embodiment 1

[0031] 0.047 g (100 μmol) of chromium pentacarbonyl tetrabutylammonium chloride was placed in a closed device and heated at 60° C. to release CO gas. Depend on figure 1 It can be seen that the initial weight loss temperature of chromium pentacarbonyl tetrabutylammonium chloride in a static air atmosphere is 60 °C.

[0032] Using the principle that deoxymyoglobin (dexoy-Mb) combines with CO to form carboxymyoglobin (Mb-CO), the amount of pyrolytic CO released by chromium pentacarbonyl tetrabutylammonium chloride is detected. The specific method is as follows:

[0033] 5 mg of horse myoglobin was dissolved in 5 mL of pH=7.4 PBS buffer solution to obtain a myoglobin solution of about 66 μmol / L. During the test, use a pipette to weigh 1 mL of myoglobin solution into a cuvette, add 25 mg of hydrosulfite (Na 2 S 2 O 4 ), mix well to obtain a deoxymyoglobin solution, test its absorption spectrum at 500-600 nm in a UV-Vis spectrophotometer to obtain the Mb curve, and then pass CO ...

Embodiment 2

[0036] 0.047 g (100 μmol) of chromium pentacarbonyl tetrabutylammonium chloride was placed in a closed device and heated at 80° C. to release CO gas. according to image 3 It can be obtained that the CO release amount of tetrabutylammonium pentacarbonyl chloride at this temperature is 0.32 μmol / g.

Embodiment 3

[0038] 0.047 g (100 μmol) of chromium pentacarbonyl tetrabutylammonium chloride was placed in a closed device and heated at 100° C. to release CO gas. according to Figure 4 It can be obtained that the CO release amount of tetrabutylammonium pentacarbonyl chloride at this temperature is 0.33 μmol / g.

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Abstract

The invention discloses a method of pyrolysis and slow release of carbon monoxide by a metal carbonyl complex. A pentacarbonyl chromium halogenated ion quaternary ammonium compound is used as a carbonmonoxide releasing molecule, the slow release of pure carbon monoxide can be carried out under heating conditions, meanwhile, the physical property is stable, light is not required to be avoided, andair is not required to be isolated, long-term storage can be achieved, so that the pentacarbonyl chromium halogenated ion quaternary ammonium compound is an ideal medical CO-RM. A myoglobin immune test proves that the method can effectively pyrolyze the CO-RM and slow release CO, and the carbonylation process of a micromolar protein solution can be realized. Meanwhile, a complicated air pressurecontrol device required by an existing carbon monoxide release treatment can be avoided, the use of the high-pressure and highly toxic carbon monoxide gas cylinder can be avoided fundamentally, so thesafe, convenient and micro CO release are realized, and the bottleneck problem of the clinical treatment application of CO is solved.

Description

technical field [0001] The invention relates to a safe and convenient way of releasing carbon monoxide, in particular to a method for releasing carbon monoxide by pyrolysis of metal carbonyl compounds. Background technique [0002] In recent years, medical research has found that endogenous carbon monoxide is an important biological messenger molecule in the human body, which has important physiological functions such as anti-cancer, anti-inflammatory, inhibiting organ transplant rejection and inhibiting ischemia-reperfusion injury (Nat.Rev . Drug. Disc., 2010, 9, 728). Controlling the intake of trace carbon monoxide is associated with acute lung injury (Am J Physiol Lung Cell Mol Physiol., 2008, 294, 642–643), gastric ulcer (FREE RADICAL RESEARCH, 2016, 50(10), 1098–1105), chronic enteritis (Current Medicinal Chemistry) , 2012, 19, 70-76) and suppressor transplant rejection, etc., and the application of trace carbon monoxide therapy in intestinal paralysis after colon surg...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61P9/08A61P31/04C01B32/40
CPCA61K41/0028A61P9/08A61P31/04C01B32/40
Inventor 张伟强王红霞郭萌林德智张晓
Owner SHAANXI NORMAL UNIV
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