Composite material for processing miniature bone fixation nail and its preparation method

Abstract

The invention discloses a composite material for processing miniature bone fixation nails and a preparation method thereof. The material comprises adding biologically active inorganic materials and zeolite imidazolate structural material ZIF-8 into a solution of biologically active binding materials , at pH 8-10 and stirring at room temperature, so that the bioactive binding material is coated with ZIF-8 on the bioactive inorganic material during polymerization, and then added to the bone scaffold matrix material in a high-speed blender to make it uniformly dispersed, It can be obtained by banburying, blending and granulating. Because the composite material of the present invention contains bone scaffold matrix material, bioactive inorganic material and zeolite imidazolate structural material ZIF‑8, on the one hand, it can strengthen the bone scaffold matrix material matrix, delay the early degradation of the material, and improve the material's ability to guide the body itself. Osteogenic ability and biocompatibility, on the other hand, can also endow the bone scaffold matrix material with inductivity and antibacterial properties, and the preparation method is simple, the cost is low, and it is convenient for popularization and application.

Description

technical field [0001] The invention belongs to the technical field of processing bone-retaining screw materials and its preparation, and in particular relates to a composite material for processing miniature bone-retaining screws and a preparation method thereof. Background technique [0002] Aging diseases such as osteoporosis are one of the main causes of fractures, and an osteoporotic fracture occurs every 3 seconds in the world. In bone repair, the miniature bone fixation screw is a very important and fine fixation device, which is small in size (one-dimensional size is less than 100 μm), light in weight (generally no more than 100 mg), and high in precision, which is difficult to be processed by traditional processing methods. Large-scale preparation. Therefore, for fractures in small parts such as the spine, jaw, and ribs, the processing accuracy, mechanical strength, and biological properties of the micro-bone fixation screw are the key points and difficulties for t...

AI Technical Summary

Problems solved by technology

[0003] Traditional bone fixation nails are mostly made of alloy or ceramic materials, the surface bioactivity is not high, not only lacks osteoinductivity, but also needs to be removed through a two-stage operation, which increases the pain of the patient, and the cavity left by the operation also has a potential risk of fracture

Although the bone fixation nails with absorbable polymer materials as the main body are degradable and do not require secondary surgery to remove them, unfortunately, the mechanical strength is not good, only 40-60 MPa, and usually can only be used for muscle tension. less forceful fracture site

Another example is the chemical composition of Japan's "GRANDFIX" bone fixation nail, which is PLA. Although it has the advantages of high biocompatibility and no side effects, it has no osteoinductive properties because it has no osteoinductive materials.

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