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Method for completely separating oleic acid and linoleic acid

A technology of complete separation and linoleic acid, applied in the field of complete separation of oleic acid and linoleic acid, can solve the problem of reducing to below 0.5%, achieve the effect of no sample loss, good environmental protection function, and large production volume

Active Publication Date: 2019-12-20
SHANGHAI TAUTO BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is difficult to reduce the content of linoleic acid to less than 0.5% by traditional separation and purification methods

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Mix n-hexane, acetonitrile, and water at a volume ratio of 6:6:2 to prepare a solvent system, add it to a separatory funnel, shake it well, let stand to separate the phases, and obtain a two-phase mixture, and collect the upper phase and the lower phase separately Solvent, respectively placed in an ultrasonic oscillator for ultrasonic degassing treatment, 70-80% high-purity oleic acid is dissolved in the upper phase solvent, and high-speed countercurrent chromatography is used for separation: 0-60 minutes forward and forward rotation, the upper phase is fixed phase, the lower phase is the mobile phase, and a mixed solution of linoleic acid and the lower phase is obtained; 60 to 90 minutes, reverse connection and forward rotation, the lower phase is the stationary phase, and the upper phase is the mobile phase, and a mixed solution of oleic acid and the upper phase is obtained; Wherein the chromatographic condition is set to: rotating speed is 800rpm; Column temperature 2...

Embodiment 2

[0026] Mix n-heptane, ethanol, and water at a volume ratio of 8:8:1 to prepare a solvent system, add it to a separatory funnel, shake it well, let stand to separate the phases, and obtain a two-phase mixed liquid, collect the upper phase and the lower phase separately Phase solvent, respectively placed in an ultrasonic oscillator for ultrasonic degassing treatment, 70-80% high-purity oleic acid is dissolved in the upper phase solvent, and high-speed countercurrent chromatography is used for separation: 0-50 minutes forward to forward rotation, the above phase is The stationary phase, the lower phase is the mobile phase, and the mixed solution of linoleic acid and the lower phase is obtained; 50 to 80 minutes, reverse connection and forward rotation, the lower phase is the stationary phase, and the upper phase is the mobile phase, and the mixed solution of oleic acid and the upper phase is obtained Wherein the chromatographic conditions are set to: rotating speed is 800rpm; Colu...

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Abstract

The invention relates to a method for completely separating oleic acid and linoleic acid. The method comprises the following steps: fully shaking a solvent system, carrying out standing for separatingphases, and separately collecting the upper phase and the lower phase; dissolving 70-80% high-purity oleic acid in the upper phase, and carrying out separating by adopting high-speed counter-currentchromatography. Starting from sample feeding, firstly, forward connection and forward rotation are carried out, wherein the upper phase is a fixed phase, the lower phase is a mobile phase, and a mixedsolution of linoleic acid and the lower phase is obtained; then reverse connection and forward rotation are carried out, wherein the lower phase is a fixed phase, the upper phase is a mobile phase, and a mixed solution of oleic acid and the upper phase is obtained; and the lower phase and the upper phase are removed to separately obtain linoleic acid and oleic acid. According to the method, the oleic acid with purity of more than 99% is obtained by separating and purifying 70-80% high-purity oleic acid by using a high-speed counter-current chromatography technology for the first time, reagents of the solvent system can be recycled, and in theory, 100% of oleic acid can be recycled.

Description

technical field [0001] The invention belongs to the technical field of unsaturated fatty acid processing, in particular to a method for completely separating oleic acid and linoleic acid. Background technique [0002] Oleic acid is a monounsaturated omega-9 fatty acid with 18 carbon atoms and 1 double bond. Oleic acid is mainly derived from nature and exists in animal and vegetable oils in the form of glyceride. Oleic acid can be obtained by saponifying and acidifying oils and fats with high oleic acid content. Natural oleic acid has a certain effect on softening blood vessels and provides the energy needed by the body. It has the effect of lowering blood sugar, regulating blood fat and lowering cholesterol. [0003] Linoleic acid is a polyunsaturated omega-6 essential fatty acid containing 18 carbon atoms and 2 double bonds. Linoleic acid, together with other fatty acids, exists in animal and vegetable oils in the form of glycerides, and is the main component of dry and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/48C07C57/12
CPCC07C51/48C07C57/12
Inventor 邓力余琦
Owner SHANGHAI TAUTO BIOTECH CO LTD
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