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Night cream containing cannabidiol CBD nanoemulsion and preparation method thereof

A technology of cannabidiol and nanoemulsion, which is applied in the direction of medical preparations containing active ingredients, skin care preparations, pharmaceutical formulas, etc., can solve the restrictions on the diversified application of cannabidiol CBD, poor water solubility of cannabidiol CBD, biological Problems such as low utilization, to achieve drug safety, repair damaged cells, and whiten the skin

Inactive Publication Date: 2019-12-13
云南辰锦威生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, due to the extremely poor water solubility of cannabidiol CBD, most of the existing technologies directly add cannabidiol CBD to products, resulting in low bioavailability and poor transdermal absorption, which limits the diversified application of cannabidiol CBD to a certain extent

Method used

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  • Night cream containing cannabidiol CBD nanoemulsion and preparation method thereof
  • Night cream containing cannabidiol CBD nanoemulsion and preparation method thereof
  • Night cream containing cannabidiol CBD nanoemulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A night cream containing cannabidiol CBD nanoemulsion and a preparation method thereof, through the following steps:

[0047] (1) Prepare night cream with the following mass percentage raw materials:

[0048]

[0049] (2) Add an appropriate amount of water to the moisturizing agent collagen and sodium lactate, fully dissolve it in a water bath at 60°C, then add the extract of Aurantia chinensis, extract of thistle, and extract of Ling Xiaohua to stir and promote dissolution, and then add the thickener whale The wax alcohol and xanthan gum are fully dissolved, the temperature is maintained at 35°C, and the ultrasonic power is 20%, the ultrasonic start time is 5s, the ultrasonic off time is 10s, and the total duration is 7min. After ultrasonic treatment, the material is obtained B;

[0050] (3) Mix the sealing agent grape seed oil, antioxidant tocopherol and appropriate amount of water, heat at 60°C for 5 minutes until fully dissolved, then cool at room temperature, add...

Embodiment 2

[0062] A night cream containing cannabidiol CBD nanoemulsion and a preparation method thereof, through the following steps: (1) prepare night cream according to the following mass percentage raw materials:

[0063]

[0064] (2) Add an appropriate amount of water to the moisturizing agent collagen and sodium lactate, fully dissolve it in a water bath at 40°C, then add the extract of Aurantia chinensis, extract of thistle, and extract of Ling Xiaohua to stir and promote dissolution, and then add the thickener whale The wax alcohol and xanthan gum are fully dissolved, and the temperature is maintained at 40°C. Then, the ultrasonic power is 10%, the ultrasonic start time is 10s, the ultrasonic off time is 5s, and the total duration is 5min. After ultrasonic treatment, the material is obtained B;

[0065] (3) Mix the sealing agent grape seed oil, antioxidant tocopherol and appropriate amount of water, heat at 40°C for 10 minutes until fully dissolved, then cool at room temperatu...

Embodiment 3

[0078] A night cream containing cannabidiol CBD nanoemulsion and a preparation method thereof, through the following steps: (1) prepare night cream according to the following mass percentage raw materials:

[0079]

[0080] (2) Add an appropriate amount of water to the moisturizing agent collagen and sodium lactate, fully dissolve at 45°C, then add the extracts of Aurora japonica, extract of thistle, and extract of Ling Xiaohua to stir and promote dissolution, and then add the thickener cetyl alcohol 1. The xanthan gum is fully dissolved, the temperature is maintained at 45°C, and the ultrasonic power is 15%, the ultrasonic start time is 7s, the ultrasonic off time is 10s, and the total duration is 15min, after ultrasonic treatment, the material B is obtained;

[0081] (3) Mix the sealing agent grape seed oil, antioxidant tocopherol and appropriate amount of water, heat at 45°C for 7 minutes until fully dissolved, then cool at room temperature, add emulsifier Cypic DG-305, a...

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Abstract

The invention relates to night cream containing a cannabidiol CBD nanoemulsion and a preparation method thereof. The night cream is prepared from the following raw materials (by mass): 1-10% of SeppicDG-305, 0.1-1% of a callicarpa macrophylla extract, 0.1-1% of a common cephalanoplos herb extract, 0.1-1% of a campsis grandiflora extract, 1-15% of grape seed oil, 0.1-0.5% of phenoxyethanol, 0.1-3%of collagen, 0.05-1% of tocopherol, 1-3% of cetyl alcohol, 0.1-1% of xanthan gum, 1-5% of sodium lactate, 5-50% of CBD nanoemulsion and the balance of water. The cannabidiol CBD is firstly dissolvedin an oil phase, and the cannabidiol CBD nanoemulsion with good stability and transdermal absorbability is prepared; and then the CBD nanoemulsion matches a mineral concentrate, callicarpa macrophylla, common cephalanoplos herb and the campsis grandiflora extract to have a synergistic effect. The product has effects of repairing damaged cells, moisturizing the skin, soothing and whitening the skin, making the skin more elastic and finer and smoother, has remarkable effects, and is safe to use.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to a night cream containing cannabidiol CBD nanoemulsion and a preparation method thereof Background technique [0002] Night cream is used to maintain the damaged skin during the day after cleansing at night, nourish the skin, accelerate cell metabolism, enhance the elasticity and smoothness of the skin, so as to help the skin maintain the barrier, prevent the skin from dehydration, and supplement nutrition. Nowadays, most of the night cream products only have the effect of nourishing and moisturizing, and a small part has the effect of repairing. The drug transdermal effect is poor. The use of macromolecular raw materials can only stay on the surface of the skin, which is difficult for the skin to absorb, resulting in a large loss of effective substances. In order to meet the requirements for deep care of the face and nutritional supplements, the field of cosmetics urgently needs a night ...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/06A61K8/34A61K8/92A61K8/65A61K8/67A61K8/73A61Q19/00A61Q19/02
CPCA61K8/068A61K8/342A61K8/347A61K8/65A61K8/678A61K8/73A61K8/922A61K8/9789A61K2800/5922A61K2800/82A61K2800/84A61Q19/00A61Q19/02
Inventor 李映波冯红宋小雪孙笠雯罗凡雅
Owner 云南辰锦威生物科技有限公司
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