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Antibacterial temperature-controlled micro-nano fiber and preparing method thereof

A micro-nano fiber and antibacterial technology, which is applied in the field of antibacterial temperature-controlled micro-nano fibers and their preparation, can solve the problems of uninvolved intelligent responsiveness of fibers, poor order of micro-nano fibers, and difficult operation, etc. effect, good compatibility, and the effect of improving antibacterial properties

Active Publication Date: 2019-12-03
EASTERN LIAONING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned existing technologies all prepare oriented nanofibers, but consume a lot of energy, are difficult to operate, and the order of micro-nanofibers is poor, and the intelligent response of fibers has not yet been involved.

Method used

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  • Antibacterial temperature-controlled micro-nano fiber and preparing method thereof
  • Antibacterial temperature-controlled micro-nano fiber and preparing method thereof
  • Antibacterial temperature-controlled micro-nano fiber and preparing method thereof

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preparation example Construction

[0036] In the present invention, the preparation method of the modified sericin solution preferably includes the following steps:

[0037]Under the protection of oxygen, the sericin aqueous solution is mixed with tyrosinase, and the enzyme-catalyzed oxidation reaction is carried out to obtain the sericin quinone solution;

[0038] The sericin quinone solution is mixed with the cecropin antimicrobial peptide to obtain the modified sericin solution.

[0039] In the invention, under the protection of oxygen, the sericin aqueous solution is mixed with tyrosinase, and the enzyme-catalyzed oxidation reaction is carried out to obtain the sericin quinone solution.

[0040] In the present invention, the concentration of the sericin aqueous solution is preferably 10-20 wt%, more preferably 12-18 wt%, more preferably 14-16 wt%; the dosage of the tyrosinase is preferably 2000-4500 U / g , more preferably 2500 to 4000 U / g, more preferably 3000 to 3500 U / g.

[0041] In the present invention...

Embodiment 1

[0059] Preparation of modified sericin solution

[0060] Under the condition of oxygen protection and temperature at 25°C, 90mL of 10% sericin aqueous solution by mass and tyrosinase (2000U / g) enzyme catalyzed oxidation reaction for 30min. and the antimicrobial peptides are mixed and stirred under certain conditions to obtain a modified sericin solution.

[0061] Preparation of spinning dope

[0062] Under the condition of nitrogen protection, 1 mL of the above-mentioned modified sericin solution, 0.5 g of N-isopropylacrylamide, 0.04 g of N,N-methylenebisacrylamide, 0.05 g of ammonium persulfate and 2.0 mL of N,N, N,N-Tetramethylethylenediamine was mixed with 10 mL of 2% acetic acid, and subjected to free radical polymerization at 60°C for 4 hours to obtain an antibacterial thermosensitive hydrogel.

[0063] Mix the antibacterial thermosensitive hydrogel with 10% by mass polyethylene oxide (relative molecular mass: 40kDa) aqueous solution according to the volume ratio of 1:5...

Embodiment 2

[0069] Preparation of modified sericin solution

[0070] Under the condition of oxygen protection and temperature at 35°C, 90mL of 15% sericin aqueous solution by mass percentage and tyrosinase (3000U / g) enzyme catalyzed oxidation reaction for 45min. and the antimicrobial peptides are mixed and stirred under certain conditions to obtain a modified sericin solution.

[0071] Spinning dope preparation

[0072] Under the condition of nitrogen protection, 1 mL of the above-mentioned modified sericin solution, 0.5 g of N-isopropylacrylamide, 0.04 g of N,N-methylenebisacrylamide, 0.05 g of ammonium persulfate and 2.0 mL of N,N, N,N-Tetramethylethylenediamine was mixed with 10 mL of 2% acetic acid for free radical polymerization to obtain an antibacterial thermosensitive hydrogel.

[0073] Mix the antibacterial thermosensitive hydrogel with 10% by mass polyethylene oxide (relative molecular mass: 40kDa) aqueous solution according to the volume ratio of 2:5, stir at room temperature...

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Abstract

The invention provides an antibacterial temperature-controlled micro-nano fiber and a preparing method thereof, and belongs to the technical field of fiber materials. Sericin with the antibacterial property is grafted by tyrosinase and cecropin, and the antibacterial property of the sericin is further improved. Moreover, a modified sericin solution is mixed with N-isopropylacrylamide, N,N-methylene bisacrylamide, ammonium persulfate, N,N,N,N-tetramethylethylenediamine and acetic acid, and gel with temperature sensitivity is obtained through free radical polymerization. In addition, by adjusting the microfluid spinning flow rate to be 10-40 microliters per second and the spinning rate to be 10-90 rad / min, the specific surface area of the micro-nano fiber is increased, the fiber nanometer effect is improved, and the antibacterial performance of the micro-nano fiber is improved. It shows through data that the antibacterial temperature-controlled micro-nano fiber has the good antibacterialproperty and the antibacterial rate can reach 99.99% or above at most.

Description

technical field [0001] The invention relates to the technical field of fiber materials, in particular to an antibacterial temperature-controlled micro-nano fiber and a preparation method thereof. Background technique [0002] Micro-nanofibers have been widely used in various fields of biomedical research because their microstructure is similar to natural extracellular matrix, especially in the nervous system, blood vessels, muscles, artificial extracellular matrix, etc. Application is extremely important. [0003] Patent CN 201810607084 discloses an antibacterial nanofiber and its preparation method. In this invention, the nanofiber is prepared by means of physical and chemical technology, and the nanofiber is antibacterially treated by loading an antibacterial agent to obtain the nanofiber. However, nanofibers are disordered, and the antibacterial properties of micro-nanofibers are not discussed. Patent CN 201611108902.2 and patent CN 201611109738.7 respectively disclose ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F8/02D01F8/16D01F8/10C08F289/00C08F220/54
CPCC08F289/00D01F8/02D01F8/10D01F8/16C08F220/54
Inventor 李佳路艳华程德红王勃翔刘治梅郝旭
Owner EASTERN LIAONING UNIV
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